Revista de Biología Tropical ISSN Impreso: 0034-7744 ISSN electrónico: 2215-2075

OAI: https://revistas.ucr.ac.cr/index.php/rbt/oai
Toxicidad sub-crónica y prueba de irritabilidad ocular del extracto acuoso de las hojas de <i>Plantago major</i> (Plantaginaceae)
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Keywords

plantago major
plantaginaceae
sub-chronic toxicity
irritation ocular
herbal medicine
llanten

How to Cite

García González, M., Coto Morales, T., Soto Rodríguez, G. A., & Pazos Sanou, L. (2003). Toxicidad sub-crónica y prueba de irritabilidad ocular del extracto acuoso de las hojas de <i>Plantago major</i> (Plantaginaceae). Revista De Biología Tropical, 51(3-4), 635–638. Retrieved from https://revistas.ucr.ac.cr/index.php/rbt/article/view/15832

Abstract

For the sub-chronic toxicity an aqueous preparation of Plantago major leaves was tested in 20 male NGP mice, with an average weight of 20.15 g and separated in two groups of ten individuals each. The dose used was 2000 mg/kg and the control group received 0.5 ml of distilled water. The extract administration was done daily during five days at week for a total period of 40 days. Signs of sub-chronic toxicity were observed in the days two and 12 of treatment. No significant change in corporal weight was observed. The ocular irritation was tested in five New Zeland male rabbits, with an average weight of 3.640 kg. The dose used was a 200 μl the preparation (100 mg/ml) of Plantago major leaves, instill into the right eye and the control was used the left eye instill 200 μl of distilled water. The administration was done daily during five days. The extract shows no significant irritation during the observation period.
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