Abstract
Biomarkers are molecules that can be objectively measured and evaluated as indicators of normal biological processes, pathological processes or pharmacological responses to therapeutic intervention. In the crevicular gingival fluid, biomarkers have been studied as host proteins including enzymes, immunoglobulins, interleukins, cytokines, chemokines and prostaglandins, which could be helpful in evaluating periodontal diagnosis and treatment outcomes, as well as monitoring patients at risk of develop periodontitis. The purpose of this review is to show some of the most studied biomarkers in periodontal disease.
References
Flemmig TF. Periodontitis. 1999 International Workshop for a Classification of Periodontal Diseases and Conditions. Annals of Periodontol; 4: 35-40.
Page R., Offenbaacher S., Schoeder H., Seymour G., Kornman K. Advances in the pathogenesis of periodontitis: summary of developments, clinical implications and future directions. Periodontology 2000 1997; 14: 216-248.
Goodson J. M. Diagnosis of periodontitis by Physical measurement interpretation from episodic disease hypothesis. J Periodontol 1992: 634: 373-378.
Taba M., Kinney J., Kim A., Giannobile W. Diagnostic Biomarkers for Oral and Periodontal Diseases. Dent Clin N Am 2005; 49: 551-71.
Biomarkers Definitions Group. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther 2001; 69: 89-95.
Ozmeric N. Advances in periodontal disease markers. Clin Chim Acta 2004; 343: 1-16.
Zambon J. J., Nakamura M., Slots J. Effect of periodontal therapy on salivary enzymatic activity. J Periodontal Res 1985; 20: 652-9.
Embery G., Waddington R. Gingival Crevicular Fluid: biological markers of periodontal tissue activity. Adv Dent Res 1994; 8: 329-336.
Eley B. M., Cox S. W. Proteolitic and hydrolytic enzymes from putative periodontal pathogens. Characterization, molecular genetics, effects pm host defences and tisues and detection in gingival crevicular fluid. Periodontol 2000 2003; 31: 105-124.
Ebersole J. Humoral Inmune responses in gingival crevicular fluid and systemic implications. Periodontol 2000 2003; 31: 135-166.
Barros S., Williams R., Offenbacher S., Morelli T. Gingival crevicular fluid as source of biomarkers for periodontitis. Periodontol 2000 2016; 70: 53-64.
Narayanan A. S., Page R. C. Connective tissues of the periodontium: a summary of current work. Coll Relat Res 1983; 3 (1): 33-64.
Eriksen E. F., Charles P., Melsen F., et al. Serum markers of Type I collagen formation and degradation in metabolic bone disease: correlation with bone histomorphometry. J Bone Miner Res 1993; 8: 127-132.
Uebelhart D., Gineyts E., Chapuy M. C. Urinary excretion of pyridinium crosslinks: a new marker of bone resorption in metabolic bone disease. Bone Miner 1990; 8: 87-96.
Garnero P., Gineyts E., Riou J. P. Assesment or bone resorpt on with a new marker of collagen degradation in patients with metabolic bone disease. J Clin Endocrinol Metab 1994; 79: 780-5.
Palys M. D., Haffajee A. D., Socransky S. S., et al. Relationship between C-telopeptide pyridinoline cross-links (ICTP) and putative periodontal pathogens in periodontitis. J Clin Peridontol 1998; 25: 865-71.
Oringer R. J., Palys M. D., Iranmanesh A., et al. C-telopeptide pyridinoline Cross-links (ICTP) and periodontal pathogens associated with endosseous oral implants. Clin Oral Implants Res 1998; 9: 365-73.
Golub L. M., Lee H. M., Greenwwald R. A., et al. A matrix metalloproteinase inhibitor reduces bone type collagen degradation fragments and specific collagenases in gingival crevicular fluid during adult periodontitis. Inflamm Res 1997; 46: 615-9.
Giannobile W. V., Lynch S. E., Denmark R. G. Crevicular fluid Osteocalcin and pyridiniline cross linked carboxyterminal telopeptide of type I collagen (ICTP) as markers of rapid bone turnover in periodontitis. A pilot study in beagle dogs. J Clin Peridontol 1995; 22: 903-10.
Khalaf F., Al-Shammari, Giannobile W.,et al. Effect of non-surgical periodontal therapy on c-telopeptide pyridinoline cross-links (ICTP) and interleukin-1 levels. J Periodontol 2001; 72: 1045-51.
González J., Rivera S. Pyridinoline (ICTP) levels in Gingival Crevicular fluid (GCF) in chronic periodontitis. Odovtos-Int. J. Dental Sc., 2016, 18-3:61-68.
González J., Rivera S. Effect of nonsurgical treatment on levels of Pyridinoline (ICTP) levels in Gingival Crevicular fluid (GCF). Odovtos-Int. J. Dental Sc., 2017, 19-1: 75-85.
Lian J. B., Gundberg C. M. Osteocalcin. Biochemical considerations and clinical applications. Clin Orthop 1988; 226:227-91.
Glowacki J., Lian JB. Impaired recruitement and differentiation of osteoclast progenitors by osteocalcin deplete bone implants. Cell differ 1987; 21: 247-54.
Price P., Baukol S. 1,25 (OH) 2D3 increases synthesis of the vitamin K dependent protein by osteosarcoma cells. Journal of Biological Chemistry 255, 1160-63.
Yamazura S., Aloia J., et al. Serum osteocalcin and total body calcium in normal, pre and postmenopausal women and post-menopausal osteoporotic patients. J Clinic End Met 1987,64: 681.
Lee A. J., Walsh T. F., et al. Gingival crevicular fluid osteocalcin in adults periodontitis. J Clin Peridontol 1999; 26. 252-6.
Nakashima K., Giannopoulou C., Andersen E., et al. A longitudinal study of various crevicular fluid components as markers of periodontal disease activity. J Clin Peridontol 1996; 23: 832-8.
Jorquera R., González J., Gutierrez S., Jorquera O., Rivera S. Osteocalcin in Gingival Crevicular Fluid of Progressive Chronic Periodontitis. Periodontia. 2009; 19: 89-93.
González Quesada DDS, MSc, J., & Rivera Alvarez DDS, S. Effect of Nonsurgical Periodontal Treatment on Levels of Pyridinoline (ICTP) in the Gingival Crevicular Fluid (GCF). Odovtos-International Journal of Dental Sciences, 2017; 19 (1): 77-85. doi:http://dx.doi.org/10.15517/ijds.v19i1.27465
Offenbacher S., Heasman P., Collins J. Modulation of host PGE2 secretion as a determinant of periodontal disease expression. J Periodontol 1993; 64: 432-444.
Lamster I. Evaluation of components of gingival crevicular fluid as diagnostic tests. Ann Periodontol 1997; 2: 123-137.
Haesman P., Collins J., Offenbacher S. Changes in crevicular fluid levels of IL-1β, LTD4, PGE2, TXB2 and TNFα in experimental gingivitis in humans. J Periodontal Res 1993; 28: 241-47.
Offenbacher S., Odle B., van Dyke T. The use of crevicular fluid prostaglandin E2 levels as a predictor of periodontal attachment loss. J Periodontal Res 1986; 21: 101-112.
Preshaw P., Haesman P. Prostaglandin E2 concentration in gingival crevicular fluid: observations in untreated chronic periodontitis. J Clin Periodontal 2002; 29: 15-20.
Yao Z., Painter S., Fanslow W., Macduff B., Spriggs M., Armitage R. Human IL-17: a novel cytokine derived from T cells. The Journal of Inmunology 1995; 155: 5483-5486.
Ferretti S., Bonneau O., Dubois G., Jones C., Trifilieff A. IL-17, produced by lymphocytes and neutrophils, is necessary airway neutrophilia: IL-15 as a possible trigger. J of Inmunology 2003; 170: 2106-2112.
Chabaud M., Garnero P., Dayer J., Guerne P., Fossiez F., Miossec P. Contribution of IL-17 to synovium matrix destruction in rheumatoid arthritis. Cytokine 12 2000, 1092-1099.
Vernal R., Dutzan N., Chaparro A., Puente J., Valenzuela M. A., Gamonal J. Levels of interleukin-17 in gingival crevicular fluid and in supernatants of gingival tissue from patients with chonic periodontitis. J Clin Periodontol 2005; 32: 383-89.
Fossiez F., Djossou O., Chomarat P., FloresRomo L., Ait- Yahia, Maat C., Pin J., Garrone P. T. cell IL-17 induces stromal cells to produce proinflammatoriy and hematopoietic cytokines. J of Experimental Medicine 1996; 183: 2593-2603.
Kotake S., Udagawa N., Takahashi N., Matsuzaki K., Kamatani N., Gillespie M., Martin T., Suda T. IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J of Clinical Investigation 1999;103: 1345-1352.
Lubberts E., van den Bersselaar, Oppers-Walgreen B., Schwarzenberger P., Coenen-de J., Kolls J., Joosten L., van der Berg W. I.L.-17 promotes Bone erotion in murine collagen induced arthritis through loss of the receptor activator of NF-kb ligand/osteoprotegerin balance. The Journal of Inmunology 2003; 170: 2655-2662.
Takahashi K., Azuma T., Motohira H., Kinane S. The potencial role of IL-17 in the inmunopathology of periodontal disease. J Clin Periodontol 2005; 32: 369-374.
González J., Jorquera R., Jorquera O., Rivera S. Niveles de interleukina 17 en el fluido gingival crevicular de pacientes con periodontitis crónica progresiva. Avances en Periodoncia e Implantología Oral. 2009; 21 (3): 157-162.
Chambers D., Crawford J., Mukherjee S., Cohen R. Aspartate aminotransferase increases in crevicular fluid during experimental periodontitis in beagle dogs. J Periodontol 1984; 55: 526-530.
Persson G., DeRouen T., Page Rc. Relationship between gingival crevicular fluid levels of aspartate aminotransferase and active tissue destruction in treated chronic periodontitis patients. J Peridontol Res 1990; 25: 81-7.
Oringer R., Howell H., Nevins M., Reasner D., Davis G., Sekler J., Fiorellini J. Relationship between crevicular aspartate aminotransferase levels and periodontal disease progression. J Periodontal 2001; 72: 17-24.
Chambers D., Imrey P., Cohen R., Crawford J., Alves M., McSwiggen T. A longitudinal study of aspartate aminotransferase in human gingival crevicular fluid. J Periodontol Res 1991; 26: 65-74.
González Quesada DDS, MSc, J., & Rivera Alvarez DDS, S. Effect of Nonsurgical Periodontal Treatment on Levels of Pyridinoline (ICTP) in the Gingival Crevicular Fluid (GCF). Odovtos - International Journal of Dental Sciences, 2017; 19(1): 77-85. doi:http://dx.doi.org/10.15517/ijds.v19i1.27465
Rivera S., Jorquera R., González J. Actividad de la Aspartato aminotransferasa (AST) en pacientes con enfermedad periodontal crónica. Odovtos-Int. J. Dental Sc., 2006.