https://revistas.ucr.ac.cr/index.php/clinica/issue/feed 2023-10-18T13:23:56-06:00 Willem Bujan Boza willem.bujan@ucr.ac.cr Open Journal Systems <p>Medical-scientific publication, edited by &nbsp;the School of Medicine of the University of Costa Rica, directed to professionals interested in health area. The journal is free, biannual and disseminates the clinical activity and research in CCSS (Costa Rican Social Security Organization). This is done with the support of the School of Medicine of the University of Costa Rica.</p> <p>ISSN 2215-2741</p> <p><strong>Aim</strong></p> <p><span style="font-weight: 400;">To provide an open access platform for health sciences professionals and students so they can publish scientific papers of clinical relevance that represent national (Costa Rica) and regional (central american region) actuality, in order to develop scientific discussions, professional development and evidence based medicine.&nbsp;</span></p> <p><strong>Scope</strong></p> <p><span style="font-weight: 400;">We publish scientific papers oriented to the clinical practice in every discipline or medical specialty, evidence based and reflecting on national and regional medical actuality. We aim to be a health sciences and clinical publishing referent for the central american region, to contribute to evidence based medicine, through high publishing quality standards in health sciences publications.</span></p> https://revistas.ucr.ac.cr/index.php/clinica/article/view/52519 2022-11-22T15:17:16-06:00 Ernesto Balmaceda Araya ernesto.balmaceda@ucr.ac.cr Valeria Armani Arce valeria.armani@ucr.ac.cr Joselyn Hernández Quirós joselyn.hernandezquiros@ucr.ac.cr María Luisa Madrigal Mora marialuisa.madrigal@ucr.ac.cr Katherine Sánchez Vargas katherine.sanchezvargas@ucr.ac.cr

<p>Sarcopenia is a muscle disease that tends to be related to aging. However, it plays an extremely relevant role in the clinic of chronic pathologies. This role is quantified by clinical tests such as the dynamometer, allowing to establish an association between the loss of muscle mass, the general condition and the prognosis of patients with different pathologies.</p> <p>The pathophysiology of sarcopenia centers on a decrease in anabolic hormone signaling and an increase in catabolic signaling through proinflammatory substances such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6). A loss of skeletal muscle function, strength and mass is generated, which favors the development of chronic diseases.</p> <p>This has a negative impact on aspects such as quality of life, patient survival, increased risk of fractures, increased cardiovascular complications, increased post-transplant complications and generally increased hospitalization and mortality rates.</p> <p>This pathology has a great relevance in the prognosis of patients with chronic diseases. An early study and detection of sarcopenia can have a significant impact on therapeutic decisions, disease progression and patient outcomes.</p>

2023-10-18T00:00:00-06:00 Copyright (c) 2023 Ernesto Balmaceda Araya, Valeria Armani Arce, Joselyn Hernández Quirós, María Luisa Madrigal Mora, Katherine Sánchez Vargas