Nanoleakage in Dentistry: 30 Years Later

Authors

  • José Luis Álvarez-Vásquez Full Professor, Discipline of Endodontics, Faculty of Dentistry, University of Cuenca, Ecuador. Author https://orcid.org/0000-0003-0381-2402
  • Nicholas G. Fischer Fellow, Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Center for Precision Engineering for Health, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Center for Innovation and Precision Dentistry, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Author https://orcid.org/0000-0003-2230-5158

DOI:

https://doi.org/10.15517/vg7z8h38

Abstract

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References

Medina J., Quispe Tasayco L., Orellana Arauco H., Muñoz W., Espinoza Carhuancho F., Mayta Tovalino F. In vitro analysis of marginal sealing using light curing techniques on aged and unaged composite resins. Odovtos-International Journal of Dental Sciences. 2025: 111-120.

Editorial Board of the Journal of Endodontics. Wanted: a base of evidence. Journal of Endodontics. 2007; 33 (12): 1401-1402.

Brenes Valverde K., Conejo Rodríguez E., Vega Baudrit J.R., Montero Aguilar M., Chavarría Bolaños D. Evaluation of microleakage by gas permeability and marginal adaptation of MTA and Biodentine™ apical plugs: in vitro study. Odovtos-International Journal of Dental Sciences. 2018; 20 (1): 57 67.

Sano H., Takatsu T., Ciucchi B., Horner J.A., Matthews W.G., Pashley D.H. Nanoleakage: leakage within the hybrid layer. Oper Dent. 1995; 20 (1):18-25.

Sano H., Yoshiyama M., Ebisu S., et al. Comparative SEM and TEM observations of nanoleakage within the hybrid layer. Oper Dent. 1995; 20 (4): 160-167.

Maravic T., Mazzitelli C., Mayer-Santos E., et al. Current Trends for Cementation in Prosthodontics: Part 1-The Substrate. Polymers (Basel). 2025; 17 (5): 566.

Breschi L., Maravic T., Mazzitelli C., et al. The evolution of adhesive dentistry: From etch-and-rinse to universal bonding systems. Dent Mater. 2025; 41 (2): 141-158.

Hashimoto M., Yamaguchi S., Imazato S. Nanoleakage and Durability of Resin/Dentin Bonds. Curr Oral Health Rep. 2015, 2: 195-201.

Hashimoto M. et al. Diffusion-induced water movement within resin-dentin bonds during bonding. J Biomed Mater Res B Appl Biomater. 2006; 79 (2): 453-8.

Hashimoto M. et al. Permeability of adhesive resin films. J Biomed Mater Res B Appl Biomater. 2005; 74 (2): 699-705).

Mokeem L.S., Garcia I.M., Melo M.A. Degradation and Failure Phenomena at the Dentin Bonding Interface. Biomedicines. 2023; 11 (5): 1256.

Betancourt D.E., Baldion P.A., Castellanos J.E. Resin-Dentin Bonding Interface: Mechanisms of Degradation and Strategies for Stabilization of the Hybrid Layer. Int J Biomater. 2019; 2019: 5268342.

Ayatollahi M.R., Yahya M.Y., Karimzadeh A., Nikkhooyifar M., Ayob A. Effects of temperature change and beverage on mechanical and tribological properties of dental restorative composites. Mater Sci Eng C Mater Biol Appl. 2015; 54: 69-75.

Olivares A., Barraza V., Aguayo S. Micro- and nano-scale adhesion of oral bacteria to biomaterials using atomic force microscopy: A systematic review. Jpn Dent Sci Rev. 2025; 61: 41-54.

El-Keredy D., Etman W., Salama M. Nanoleakage of different composite restoration systems. Tanta Dental Journal; 2020; 17 (3): 97-105.

https://pubmed.ncbi.nlm.nih.gov/?term=nanoleakage. Accessed: August 01, 2025.

Coutinho E., Cardoso M.V., Fernandes C.P., et al. Nanoleakage distribution at adhesive-dentin interfaces in 3D. J Dent Res. 2011; 90 (8): 1019-1025.

Cadenaro M., Josic U., Maravić T., et al. Progress in Dental Adhesive Materials. J Dent Res. 2023; 102 (3): 254-262.

Desai S., Tepperman A., Ben Suleiman A., et al. Pulpal Deterioration Following Restorative Procedures: A Case-Control Study. J Endod. Published online June 13, 2025.

Kim H., Jung Y.J., Kim Y., et al. Long-term hybrid stability and matrix metalloproteinase inhibition by fucosterol in resin-dentin bonding biomechanics. Sci Rep. 2024; 14 (1): 20415.

Santana V.B., de Alexandre R.S., Rodrigues J.A., Ely C., Reis A.F. Effects of Immediate Dentin Sealing and Pulpal Pressure on Resin Cement Bond Strength and Nanoleakage. Oper Dent. 2016; 41 (2): 189-199.

Vasconcelos e Cruz J., Brito J., Polido M., Gonçalves L. A new experimental adhesive system containing G-IEMA-physicochemical properties. J Adhes Sci Technol. 2018; 33 (4): 418-432.

Diefenderfer K. Has Competence Replaced Excellence? A Reprint with Foreword. Oper Dent. 2024; 49 (1): 3-4.

Bertassoni L.E., Orgel J.P., Antipova O., Swain M.V. The dentin organic matrix - limitations of restorative dentistry hidden on the nanometer scale. Acta Biomater. 2012; 8 (7): 2419-2433.

Yao C., Liang S., Yu M., et al. High-Performance Bioinspired Microspheres for Boosting Dental Adhesion. Small. 2024; 20 (29): e2310251.

Published

2025-10-01