Oxidative Stress Markers Analysis in Sites with Healthy Conditions and with Periodontal and Peri-Implant Diseases

Guarnieri, Renzo; Reda, Rodolfo; Zanza, Alessio; Bramucci, Chiara; Testarelli, Luca; Di Nardo, Dario

doi:10.15517/9g5pw090

Autores/as

Renzo Guarnieri Private Practice, Treviso, Italy. Autor/a https://orcid.org/0000-0003-1449-8340
Rodolfo Reda Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy. Autor/a https://orcid.org/0000-0003-1532-6524
Alessio Zanza Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy. Autor/a https://orcid.org/0000-0002-2062-8140
Chiara Bramucci Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy. Autor/a https://orcid.org/0009-0008-3270-9301
Luca Testarelli Department of Oral and Maxillo-Facial Sciences, Sapienza Univerisity of Rome, Italy. Autor/a https://orcid.org/0000-0003-3904-3000
DARIO DI NARDO Department of Oral and Maxillo Facial Sciences, Sapienza University of Rome Autor/a https://orcid.org/0000-0002-5054-0828

DOI:

https://doi.org/10.15517/9g5pw090

Palabras clave:

Periimplantitis; Periodontitis; Marcadores de estrés oxidativo.

Resumen

La periodontitis y la periimplantitis son enfermedades inflamatorias en las que el estrés oxidativo puede desempeñar un papel central. Este estudio evaluó los niveles de malondialdehído (MDA) y superóxido dismutasa (SOD) en el fluido crevicular gingival (GCF) y en el fluido crevicular periimplantario (PICF) de sitios sanos y enfermos. Se examinaron participantes adultos con sitios periodontales sanos (PH), periimplantarios sanos (PIH), con periodontitis (PER) o con periimplantitis (PIM). Se registraron los índices clínicos de placa (PI), gingival (GI), profundidad al sondaje (PPD) y sangrado al sondaje (BOP). Las muestras de GCF y PICF se analizaron mediante ELISA para determinar las concentraciones de MDA y SOD. Las comparaciones entre grupos y las correlaciones se evaluaron mediante ANOVA/SNK-q y las pruebas de Spearman. Se analizaron un total de 364 muestras (PH=117, PER=101, PIH=94, PIM=52) de 120 pacientes. No se encontraron diferencias significativas entre PH y PIH. En comparación con PIH, los sitios con PIM mostraron concentraciones significativamente más altas de MDA y SOD; los valores de PIM también superaron a los de PER. MDA y SOD se correlacionaron positivamente con la profundidad de sondaje y el sangrado al sondaje. Los biomarcadores de estrés oxidativo fueron significativamente más altos en los sitios periimplantarios enfermos que en los periodontales enfermos, lo que sugiere un entorno oxidativo más intenso en la periimplantitis.

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