Uses of Chitosan-Based Hydrogels in Dentistry: A Systematic Review

Authors

  • Jesús Antonio Valenciana-Solís Maestría en Ciencias Biomédicas, Área de Ciencias de la Salud, Universidad Autónoma de Zacatecas “Francisco García Salinas”, Zacatecas, Zac., México. Author https://orcid.org/0009-0007-5926-3015
  • César Gaitán-Fonseca Maestría en Ciencias Biomédicas, Área de Ciencias de la Salud, Universidad Autónoma de Zacatecas “Francisco García Salinas”, Zacatecas, Zac., México. Unidad Académica de Odontología, Universidad Autónoma de Zacatecas “Francisco García Salinas”, Zacatecas, Zac., México. Author https://orcid.org/0000-0001-6452-2578
  • Luis Alejandro Aguilera-Galavíz Maestría en Ciencias Biomédicas, Área de Ciencias de la Salud, Universidad Autónoma de Zacatecas “Francisco García Salinas”, Zacatecas, Zac., México. Unidad Académica de Odontología, Universidad Autónoma de Zacatecas “Francisco García Salinas”, Zacatecas, Zac., México. Author https://orcid.org/0000-0002-1513-4971
  • Gabriel Alejandro Martínez-Castañón Facultad de Estomatología, Universidad Autónoma de San Luis Potosí, San Luis Potosí, S.L.P., México. Author https://orcid.org/0000-0003-4982-5225
  • Verónica Zavala-Alonso Facultad de Estomatología, Universidad Autónoma de San Luis Potosí, San Luis Potosí, S.L.P., México. Author https://orcid.org/0000-0001-6014-0994
  • Carlos Bermúdez-Jiménez Maestría en Ciencias Biomédicas, Área de Ciencias de la Salud, Universidad Autónoma de Zacatecas “Francisco García Salinas”, Zacatecas, Zac., México. Unidad Académica de Odontología, Universidad Autónoma de Zacatecas “Francisco García Salinas”, Zacatecas, Zac., México. Author https://orcid.org/0000-0001-7503-350X

DOI:

https://doi.org/10.15517/ijds.2024.60340

Keywords:

Hydrogel; Chitosan; Xylitol; Remineralization, Tooth enamel.

Abstract

The objective of this article was to carry out a systematic review of the literature to determine the different therapeutic uses of chitosan-based hydrogels and their uses in dental therapy, as well as the modification and improvement of dental materials to promote research related to chitosan and its incorporation into dentistry as an adjunct or replacement in some dental treatments. Chitosan is a natural polymer obtained from the deacetylation of chitin, a polysaccharide abundant in nature, which, due to its biocompatibility, high biodegradability, non-antigenicity, and its ease of acquisition, has attracted biomedical interest, including in dentistry. Recent studies have shown that chitosan can be integrated into dental materials to obtain remineralizing effects, such as for antimicrobial agents, osteogenic agents, and pulp regeneration treatment. A bibliographic search was carried out in PubMed from 2018 to 2023. The results showed a wide range of uses for chitosan in the dental field, particularly its use as a remineralizing agent for tooth enamel; It has also been used in tissue regeneration mainly because of its osteogenic activity, as an antimicrobial agent, and as a vehicle for the application of medications. The use of chitosan as a nanobiomaterial is an interesting topic, since chitosan shows potential for new dental materials, either as an active ingredient or as an adjuvant vehicle for other materials.

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References

Wang W., Meng Q., Li Q., Liu J., Zhou M., Jin Z., et al. Chitosan Derivatives and Their Application in Biomedicine. International Journal of Molecular Sciences. 2020; 21 (2): 487. DOI: https://doi.org/10.3390/ijms21020487

Ngo D.-H., Vo T.-S., Ngo D.-N., Kang K.-H., Je J.-Y., Pham H.N.-D., et al. Biological effects of chitosan and its derivatives. Food Hydrocolloids. 2015; 51: 200-16. DOI: https://doi.org/10.1016/j.foodhyd.2015.05.023

Zhao D., Yu S., Sun B., Gao S., Guo S., Zhao K. Biomedical Applications of Chitosan and Its Derivative Nanoparticles. Polymers. 2018; 10 (4): DOI: https://doi.org/10.3390/polym10040462

Qin Y., Li P. Antimicrobial Chitosan Conjugates: Current Synthetic Strategies and Potential Applications. International Journal of Molecular Sciences. 2020; 21 (2): 499. DOI: https://doi.org/10.3390/ijms21020499

Royal Spanish Academy. Dictionary of the Spanish language [Internet]. Spain: Royal Spanish Academy; 2001. [Cited October 1, 2023]. Recovered from: https://www.rae.es/drae2001/biodegradable

Chandra R., Rustgi R. Biodegradable polymers. Progress in Polymer Science. 1998; 23 (7): 1273-335. DOI: https://doi.org/10.1016/S0079-6700(97)00039-7

Kamath K.R., Park K. Biodegradable hydrogels in drug delivery. Advanced Drug Delivery Reviews. 1993; 11 (1-2): 59-84. DOI: https://doi.org/10.1016/0169-409X(93)90027-2

Cao H., Duan L., Zhang Y., Cao J., Zhang K. Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity. Signal Transduction and Targeted Therapy. 2021; 6 (1): 426. DOI: https://doi.org/10.1038/s41392-021-00830-x

Fakhri E., Eslami H., Maroufi P., Pakdel F., Taghizadeh S., Ganbarov K., et al. Chitosan biomaterials application in dentistry. International Journal of Biological Macromolecules. 2020; 162: 956-74. DOI: https://doi.org/10.1016/j.ijbiomac.2020.06.211

Muşat V., Anghel E.M., Zaharia A., Atkinson I., Mocioiu O.C., Buşilă M., et al. A chitosan–agarose polysaccharide-based hydrogel for biomimetic remineralization of dental enamel. Biomolecules. 2021; 11 (8): 1137. DOI: https://doi.org/10.3390/biom11081137

Lacruz R.S., Habelitz S., Wright J.T., Paine M.L. DENTAL ENAMEL FORMATION AND IMPLICATIONS FOR ORAL HEALTH AND DISEASE. Physiological Reviews. 2017; 97 (3): 939-93. DOI: https://doi.org/10.1152/physrev.00030.2016

Arnaud T.M.S., de Barros Neto B., Diniz F.B. Chitosan effect on dental enamel de-remineralization: an in vitro evaluation. Journal of Dentistry. 2010; 38 (11): 848-52. DOI: https://doi.org/10.1016/j.jdent.2010.06.004

Moher D., Liberati A., Tetzlaff J., Altman D.G. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Medicine. 2009; 6 (7): e1000097. DOI: https://doi.org/10.1371/journal.pmed.1000097

Ren Q., Ding L., Li Z., Wang X., Wang K., Han S., et al. Chitosan hydrogel containing amelogenin-derived peptide: Inhibition of cariogenic bacteria and promotion of remineralization of initial caries lesions. Archives of Oral Biology. 2019; 100: 42-8. DOI: https://doi.org/10.1016/j.archoralbio.2019.02.004

Prajapati S., Ruan Q., Mukherjee K., Nutt S., Moradian-Oldak J. The Presence of MMP-20 Reinforces Biomimetic Enamel Regrowth. Journal of Dental Research. 2018; 97 (1): 84-90. DOI: https://doi.org/10.1177/0022034517728504

Zhang S., Zhao Y., Ding S., Zhou C., Li H., Li L. Facile Synthesis of In Situ Formable Alginate Composite Hydrogels with Ca (2+)-Induced Healing Ability. Tissue Engineering Part A. 2021; 27 (19-20): 1225-38. DOI: https://doi.org/10.1089/ten.tea.2020.0282

Zhang Y., Dou X., Zhang L., Wang H., Zhang T., Bai R., et al. Facile fabrication of a biocompatible composite gel with sustained release of aspirin for bone regeneration. Bioact Mater. 2022; 11: 130-9. DOI: https://doi.org/10.1016/j.bioactmat.2021.09.033

Makar L.E., Nady N. Unmodified Gum Arabic/Chitosan/Nanohydroxyapatite Nanocomposite Hydrogels as Potential Scaffolds for Bone Regeneration. Polymers. 2022; 14 (15): 3052. DOI: https://doi.org/10.3390/polym14153052

Sungkhaphan P., Thavornyutikarn B. Antibacterial and osteogenic activities of clindamycin-releasing mesoporous silica/carboxymethyl chitosan composite hydrogels. Royal Society Open Science. 2021; 8 (9): 210808. DOI: https://doi.org/10.1098/rsos.210808

Abdul-Monem M.M., Kamoun E.A., Ahmed D.M., El-Fakharany E.M., Al-Abbassy F.H., Aly H.M. Light-cured hyaluronic acid composite hydrogels using riboflavin as a photoinitiator for bone regeneration applications. Journal of Taibah University Medical Sciences. 2021; 16 (4): 529-39. DOI: https://doi.org/10.1016/j.jtumed.2020.12.021

Afrasiabi S., Bahador A., Partoazar A. Combinatorial therapy of chitosan hydrogel-based zinc oxide nanocomposite attenuates the virulence of Streptococcus mutans. BMC Microbiology. 2021; 21 (1): 62. DOI: https://doi.org/10.1186/s12866-021-02128-y

Suflet D.M., Popescu I., et al. Dual Cross-Linked Chitosan/PVA Hydrogels Containing Silver Nanoparticles with Antimicrobial Properties. Pharmaceutics. 2021; 13 (9): 1461. DOI: https://doi.org/10.3390/pharmaceutics13091461

Abboud A.R., Ali A.M., Youssef T. Preparation and characterization of insulin-loaded injectable hydrogels as potential adjunctive periodontal treatment. Dental and Medical Problems. 2020; 57 (4): 377-84. DOI: https://doi.org/10.17219/dmp/125658

Chanaj-Kaczmarek, Justyna, et al. Development and Evaluation of Thermosensitive Hydrogels with Binary Mixture of Scutellariae baicalensis radix Extract and Chitosan for Periodontal Diseases Treatment. International Journal of Molecular Sciences. 2021; 22 (21): 11319. DOI: https://doi.org/10.3390/ijms222111319

Ammar M.M., Waly G.H., Saniour S.H., Moussa T.A. Growth factor release and enhanced encapsulated periodontal stem cells viability by freeze-dried platelet concentrate loaded thermo-sensitive hydrogel for periodontal regeneration. The Saudi Dental Journal. 2018; 30 (4): 355-64. DOI: https://doi.org/10.1016/j.sdentj.2018.06.002

Wu S., Zhou Y., et al. Evaluation of Chitosan Hydrogel for Sustained Delivery of VEGF for Odontogenic Differentiation of Dental Pulp Stem Cells. 2019; 2019: 1515040. DOI: https://doi.org/10.1155/2019/1515040

Renard E., Amiaud J., Delbos L., Charrier C., Montembault A., Ducret M., et al. Dental pulp inflammatory/immune response to a chitosan-enriched fibrin hydrogel in the pulpotomised rat incisor. European Cells & Materials. 2020; 40: 74-87. DOI: https://doi.org/10.22203/eCM.v040a05

Moreira M.S., Sarra G., et al. Physical and Biological Properties of a Chitosan Hydrogel Scaffold Associated to Photobiomodulation Therapy for Dental Pulp Regeneration: An In Vitro and In Vivo Study. BioMed Research International. 2021; 2021: 6684667. DOI: https://doi.org/10.1155/2021/6684667

Divband B., Pouya B., et al. Towards Induction of Angiogenesis in Dental Pulp Stem Cells Using Chitosan-Based Hydrogels Releasing Basic Fibroblast Growth Factor. BioMed Research International. 2022; 2022: 5401461. DOI: https://doi.org/10.1155/2022/5401461

Erten Taysi A., Cevher E., et al. The efficacy of sustained-release chitosan microspheres containing recombinant human parathyroid hormone on MRONJ. Brazilian Oral Research 2019; 33: e086. DOI: https://doi.org/10.1590/1807-3107bor-2019.vol33.0086

Hosny K.M., Sindi A.M., Alkhalidi H.M., Kurakula M., Alruwaili N.K., Alhakamy N.A., et al. Oral gel loaded with penciclovir-lavender oil nanoemulsion to enhance bioavailability and alleviate pain associated with herpes labialis. Drug Delivery. 2021; 28 (1): 1043-54. DOI: https://doi.org/10.1080/10717544.2021.1931561

Published

2026-04-27