Artificial Intelligence in CBCT-Based Periodontal and Peri-Implant Diagnosis: A Scoping Review

Authors

DOI:

https://doi.org/10.15517/e3t19w34

Keywords:

Artificial intelligence; Cone-beam computed tomography; Periodontitis; Peri-implantitis; Deep learning; Periodontal bone loss.

Abstract

This scoping review aimed to map the extent, nature, and characteristics of the available evidence on artificial intelligence (AI) applied to cone-beam computed tomography (CBCT)-based periodontal and peri-implant diagnosis. A scoping review was conducted in accordance with Joanna Briggs Institute methodological guidance and reported following PRISMA-ScR. A systematic search of PubMed/MEDLINE, Scopus, Web of Science, and LILACS/BVS was performed up to April 3, 2026, without language restrictions. Records were exported in RIS format, managed in Zotero for duplicate removal, and screened in Rayyan using predefined eligibility criteria. Original studies applying AI-based methods to CBCT images for periodontal and/or peri-implant diagnostic purposes were included. Data were charted descriptively to summarize study characteristics, diagnostic targets, AI models, performance metrics, and methodological limitations. Of the 358 records identified, 174 were screened after removal of duplicate records and conference papers. Twelve reports underwent full-text assessment, and 7 studies were included in the final qualitative synthesis. Most studies were published between 2024 and 2026 and focused predominantly on periodontal applications, whereas only one addressed peri-implant marginal bone loss. The most consistent findings were observed in narrowly defined tasks, particularly furcation involvement detection, periodontal bone topography segmentation, periodontal defect mapping, and peri-implant marginal bone loss grading. Broader diagnostic platforms showed more variable performance. AI applied to CBCT-based periodontal and peri-implant diagnosis represents an emerging field with still limited methodological development. This review maps the CBCT-specific evidence base and identifies priorities for advancing toward more interpretable, externally validated, and clinically useful AI systems.

Downloads

Download data is not yet available.

References

Jacobs R., Fontenele R.C., Lahoud P., Shujaat S., Bornstein M.M. Radiographic diagnosis of periodontal diseases: current evidence versus innovations. Periodontol 2000. 2024; 95 (1): 51-69. doi:10.1111/prd.12580. DOI: https://doi.org/10.1111/prd.12580

Galarraga-Vinueza M.E., Pagni S., Finkelman M., Schoenbaum T., Chambrone L. Prevalence, incidence, systemic, behavioral, and patient-related risk factors and indicators for peri-implant diseases: an AO/AAP systematic review and meta-analysis. J Periodontol. 2025; 96 (6): 587-633. doi:10.1002/JPER.24-0154 DOI: https://doi.org/10.1002/JPER.24-0154

Pitchika V., Büttner M., Schwendicke F. Artificial intelligence and personalized diagnostics in periodontology: a narrative review. Periodontol 2000. 2024; 95 (1): 220-231. doi:10.1111/prd.12586 DOI: https://doi.org/10.1111/prd.12586

Șalgău C.A., Morar A., Zgarta A.D., Ancuța D.L., Rădulescu A., Mitrea I.L., et al. Applications of machine learning in periodontology and implantology: a comprehensive review. Ann Biomed Eng. 2024; 52 (9): 2348-2371. doi:10.1007/s10439-024-03559-0 DOI: https://doi.org/10.1007/s10439-024-03559-0

Roy R., Chopra A., Karmakar S., Bhat S.G. Applications of artificial intelligence for diagnosis of periodontal/peri-implant diseases: a narrative review. J Oral Rehabil. 2025; 52 (8): 1193-1219. doi:10.1111/joor.14045 DOI: https://doi.org/10.1111/joor.14045

Schulze D., Häußermann L., Ripper J., Sottong T. Comparison between observer-based and AI-based reading of CBCT datasets: an interrater-reliability study. Saudi Dent J. 2024; 36 (2): 291-295. doi:10.1016/j.sdentj.2023.11.001 DOI: https://doi.org/10.1016/j.sdentj.2023.11.001

Shetty S., Talaat W., AlKawas S., Al-Rawi N., Reddy S., Hamdoon Z., Kheder W., Acharya A., Ozsahin D.U., David L.R. Application of artificial intelligence-based detection of furcation involvement in mandibular first molar using cone beam tomography images: a preliminary study. BMC Oral Health. 2024; 24:1476. doi:10.1186/s12903-024-05268-5 DOI: https://doi.org/10.1186/s12903-024-05268-5

Kurt-Bayrakdar S., Bayrakdar I.S., Kuran A., Çelik Ö., Orhan K., Jagtap R. Advancing periodontal diagnosis: harnessing advanced artificial intelligence for patterns of periodontal bone loss in cone-beam computed tomography. Dentomaxillofac Radiol. 2025; 54 (4): 268-278. doi:10.1093/dmfr/twaf011 DOI: https://doi.org/10.1093/dmfr/twaf011

Palkovics D., Molnar B., Pinter C., García-Mato D., Diaz-Pinto A., Windisch P., Ramseier C.A. Automatic deep learning segmentation of mandibular periodontal bone topography on cone-beam computed tomography images. J Dent. 2025; 159: 105813. doi:10.1016/j.jdent.2025.105813 DOI: https://doi.org/10.1016/j.jdent.2025.105813

Burlea Ș.L., Buzea C.G., Nedeff F., Mirilă D., Nedeff V., Agop M., et al. Deep learning analysis of CBCT images for periodontal disease: phenotype-level concordance with independent transcriptomic and microbiome datasets. Dent J (Basel). 2025; 13 (12): 578. doi:10.3390/dj13120578 DOI: https://doi.org/10.3390/dj13120578

Madani Z., Bashizadeh Fakhar H. Detection and classification of peri-implant marginal bone loss in cone-beam computed tomography using a deep learning approach. Clin Exp Dent Res. 2026;12: e70308. doi:10.1002/cre2.70308 DOI: https://doi.org/10.1002/cre2.70308

Peters M.D.J., Godfrey C., McInerney P., Munn Z., Tricco A.C., Khalil H. Updated methodological guidance for the conduct of scoping reviews. JBI Evid Synth. 2020; 18 (10): 2119-26. DOI: https://doi.org/10.11124/JBIES-20-00167

Tricco A.C., Lillie E., Zarin W., O’Brien K.K., Colquhoun H., Levac D., et al. PRISMA Extension for Scoping Reviews (PRISMA-ScR): checklist and explanation. Ann Intern Med. 2018; 169 (7): 467-73. DOI: https://doi.org/10.7326/M18-0850

Ouzzani M., Hammady H., Fedorowicz Z., Elmagarmid A. Rayyan—a web and mobile app for systematic reviews. Syst Rev. 2016; 5: 210. DOI: https://doi.org/10.1186/s13643-016-0384-4

Fagundes F.B., Papasratorn D., Elgarba B.M., Fontenele R.C., Neves F.S., Jacobs R. AI-driven gingival segmentation on CBCT: validation using delineation by intraoral scanning and CBCT-based cotton roll separation. J Dent. 2026;166:106331. doi:10.1016/j.jdent.2026.106331 DOI: https://doi.org/10.1016/j.jdent.2026.106331

Feltraco L.T., Rossetto C., Yeung A.W.K., Soares M.Q.S., Oenning A.C. Utility of the radiological report function of an artificial intelligence system in interpreting CBCT images: a technical report. Dentomaxillofac Radiol. 2025; 54 (3): 239-244. doi:10.1093/dmfr/twaf004 DOI: https://doi.org/10.1093/dmfr/twaf004

Su S., Jia X., Zhan L., Gao S., Zhang Q., Huang X. Automatic tooth periodontal ligament segmentation of cone beam computed tomography based on instance segmentation network. Heliyon. 2024; 10: e24097. doi:10.1016/j.heliyon.2024.e24097 DOI: https://doi.org/10.1016/j.heliyon.2024.e24097

Tan M., Cui Z., Li Y., Fang Y., Mei L., Zhao Y., et al. PerioAI: A digital system for periodontal disease diagnosis from an intra-oral scan and cone-beam CT image. Cell Rep Med. 2025; 6 (6): 102186. doi:10.1016/j.xcrm.2025.102186 DOI: https://doi.org/10.1016/j.xcrm.2025.102186

Khubrani Y.H., Thomas D., Slator P.J., White R.D., Farnell D.J.J. Detection of periodontal bone loss and periodontitis from 2D dental radiographs via machine learning and deep learning: systematic review employing APPRAISE-AI and meta-analysis. Dentomaxillofac Radiol. 2025; 54 (2): 89-108. doi:10.1093/dmfr/twae070 DOI: https://doi.org/10.1093/dmfr/twae070

Chatzopoulos G.S., Koidou V.P., Tsalikis L., Kaklamanos E.G. Clinical applications of artificial intelligence in periodontology: a scoping review. Medicina (Kaunas). 2025; 61 (6): 1066. doi:10.3390/medicina61061066 DOI: https://doi.org/10.3390/medicina61061066

Vázquez-Sebrango G., Anitua E., Macía I., Arganda-Carreras I. The role of artificial intelligence in implant dentistry: a systematic review. Int J Oral Maxillofac Surg. 2025. doi:10.1016/j.ijom.2025.04.005 DOI: https://doi.org/10.1016/j.ijom.2025.04.005

Li Y., Wang X., Zhu H., Ye W. The diagnostic performance of AI based on dental radiographs in predicting marginal bone loss around dental implants: a systematic review and meta-analysis. J Prosthet Dent. 2025; 134 (6): 2190.e1-2190.e11. doi:10.1016/j.prosdent.2025.08.021 DOI: https://doi.org/10.1016/j.prosdent.2025.08.021

Rezallah N.N.F., Sherif G., Abdelkarim A.Z., Afifi S. Enhancing periodontal bone loss diagnosis through advanced AI techniques. Appl Sci. 2025; 15 (12): 6832. doi:10.3390/app15126832. DOI: https://doi.org/10.3390/app15126832

Emami M., Shirani M. Application and performance of artificial intelligence in implant dentistry: an umbrella review. Dent Rev. 2025; 5 (3): 100159. doi:10.1016/j.dentre.2025.100159 DOI: https://doi.org/10.1016/j.dentre.2025.100159

Published

2026-05-26