Use and Effectiveness of Propolis on Chronic Periodontitis: a Systematic Review
DOI:
https://doi.org/10.15517/ijds.2022.48547Keywords:
Propolis; Periodontal disease; Periodontitis; Dentistry; Antibacterial; Antimicrobial.Abstract
The aim of this study was to determine the effect of propolis on non-surgical periodontal therapy in patients with chronic periodontitis (CP) as it appears in the recent literature. Propolis is a natural and biocompatible resinous substance that has shown, by means of several scientific studies, to possess medicinal properties such as antimicrobial, healing, anesthetic, anti-inflammatory, and analgesic, among others. There are several studies that have reported the use of propolis as a non-surgical treatment of CP, its comparison with other antimicrobials, and the improvement of clinical and microbiological parameters with scaling and root planing (SRP). A bibliographic search was conducted in the PubMed, Google Scholar, Web of Science, and Science Direct databases up to 2021. The results showed that there are very few reports focused on clinical studies; however, according to the analyzed data, propolis could be a good adjuvant for the treatment of patients with chronic periodontitis compared to the conventional treatment (SRP).
Downloads
References
Zabaiou N., Fouache A., Trousson A., Baron S., Zellagui A., Lahouel M., et al. Biological properties of propolis extracts: Something new from an ancient product. Chem Phys Lipids. 2017; 207 (Pt B): 214-22. DOI: https://doi.org/10.1016/j.chemphyslip.2017.04.005
Kędzia B. Pochodzenie propolisu w świetle teorii i badań naukowych. Herba Polonica. 2008; 54 (4): 179-86.
Jean-Prost P. Apicultura: conocimiento de la abeja. Manejo de la colmena: Mundi-Prensa Libros; 2007.
PERSANO A. Apicultura práctica Edit. Hemisferio Sur, Buenos Aires, argentina. 2008.
Rodríguez-Ramírez J.F., Delgado-Íñiguez F., De Velasco-Herrera P, Navarro-Hernández E, Madrigal-Elizalde E, Robles-Álvarez VM, et al. a utilidad del propóleo en las ciencias de la salud. Lux Médica. 2014; 9 (26): 31-8. DOI: https://doi.org/10.33064/26lm2014855
Sanchez M.F., Breda S.A., Soria E.A., Tártara L.I., Manzo R.H., Olivera M.E. Ciprofloxacin-lidocaine-based hydrogel: development, characterization, and in vivo evaluation in a second-degree burn model. Drug delivery and translational research. 2018; 8 (5): 1000-13. DOI: https://doi.org/10.1007/s13346-018-0523-7
Bonamigo T., Campos J.F., Alfredo T.M., Balestieri J.B.P., Cardoso C.A.L., Paredes-Gamero E.J., et al. Antioxidant, cytotoxic, and toxic activities of propolis from two native bees in Brazil: Scaptotrigona depilis and Melipona quadrifasciata anthidioides. Oxidative medicine and cellular longevity. 2017; 2017. DOI: https://doi.org/10.1155/2017/1038153
Boisard Sv, Le Ray A-M, Gatto J, Aumond M-C, Blanchard P, Derbré Sv, et al. Chemical composition, antioxidant and anti-AGEs activities of a French poplar type propolis. Journal of agricultural and food chemistry. 2014; 62 (6): 1344-51. DOI: https://doi.org/10.1021/jf4053397
Park Y.K., Alencar S.M., Aguiar C.L. Botanical Origin and Chemical Composition of Brazilian Propolis. Journal of Agricultural and Food Chemistry. 2002; 50 (9): 2502-6. DOI: https://doi.org/10.1021/jf011432b
da Silva Frozza C.O., Garcia C.S.C., Gambato G., de Souza M.D.O., Salvador M., Moura S., et al. Chemical characterization, antioxidant and cytotoxic activities of Brazilian red propolis. Food and chemical toxicology. 2013; 52: 137-42. DOI: https://doi.org/10.1016/j.fct.2012.11.013
Bankova V.S., Castro SLd, Marcucci M.C. Propolis: recent advances in chemistry and plant origin. Apidologie. 2000; 31 (1): 3-15. DOI: https://doi.org/10.1051/apido:2000102
Petrova A., Popova M., Kuzmanova C., Tsvetkova I., Naydenski H., Muli E., et al. New biologically active compounds from Kenyan propolis. Fitoterapia. 2010; 81 (6): 509-14. DOI: https://doi.org/10.1016/j.fitote.2010.01.007
de Barros M.P., Sousa J.P., Bastos J.K., de Andrade S.F. Effect of Brazilian green propolis on experimental gastric ulcers in rats. J Ethnopharmacol. 2007; 110 (3): 567-71. DOI: https://doi.org/10.1016/j.jep.2006.10.022
Salem M.M., Donia T., Abu-Khudir R., Ramadan H, Ali EMM, Mohamed TM. Propolis Potentiates Methotrexate Anticancer Mechanism and Reduces its Toxic Effects. Nutr Cancer. 2020; 72 (3): 460-80. DOI: https://doi.org/10.1080/01635581.2019.1640884
Rivero-Cruz J.F., Granados-Pineda J. Phytochemical Constituents, Antioxidant, Cytotoxic, and Antimicrobial Activities of the Ethanolic Extract of Mexican Brown Propolis. 2020; 9 (1). DOI: https://doi.org/10.3390/antiox9010070
Grange J.M., Davey R.W. Antibacterial properties of propolis (bee glue). J R Soc Med. 1990; 83 (3): 159-60. DOI: https://doi.org/10.1177/014107689008300310
de Carvalho Furtado Jr. J.H., Rocha Valadas L.A., Mendonça K.S., de Oliveira Filho R.D., Gadelha L.M., de Mello Fiallos N., et al. Propolis and its dental applications: a technological prospection. Recent patents on biotechnology. 2018; 12 (4): 288-96. DOI: https://doi.org/10.2174/2211550107666180815114855
Dewhirst F.E., Chen T., Izard J., Paster B.J., Tanner A.C., Yu W.H., et al. The human oral microbiome. J Bacteriol. 2010; 192 (19): 5002-17. DOI: https://doi.org/10.1128/JB.00542-10
Eguizábal M., Moromi Nakata H. Actividad antibacteriana in vitro del extracto etanólico de propóleo peruano sobre Streptococcus mutans y Lactobacillus casei. 2013. DOI: https://doi.org/10.15381/os.v10i2.3028
Suyo J.A.D., de Casalino D.P. Actividad antibacteriana in vitro del extracto etanólico de propóleo de Oxapampa-Perú, sobre cepas de Porphyromonas gingivalis y Fusobacterium nucleatum. Revista Estomatológica Herediana. 2011; 21 (3): 125-30. DOI: https://doi.org/10.20453/reh.v21i3.214
Almas K., Dahlan A., Mahmoud A. Propolis as a natural remedy: An update. 2001.
Momen-Beitollahi J., Mansorian A., Esmaili M., Amanlou M., Mohamadnia A., Bahrami N. Antimicrobial effects of propolis extract on the most prevalent oral pathogens: an in vitro study. Majallah i Dandanpizishki (Journal of Islamic Dental Association of Iran). 2009; 21 (1).
Scheller S., Ilewicz L., Luciak M., Skrobidurska D., Stojko A., Matuga W. Biological properties and clinical application of propolis. IX. Experimental observation on the influence of ethanol extract of propolis (EEP) on dental pulp regeneration. Arzneimittel-Forschung. 1978; 28 (2): 289-91.
Maekawa L.E., Valera M.C., Oliveira LDd, Carvalho C.A.T., Camargo C.H.R., Jorge A.O.C. Effect of Zingiber officinale and propolis on microorganisms and endotoxins in root canals. Journal of Applied Oral Science. 2013; 21 (1): 25-31. DOI: https://doi.org/10.1590/1678-7757201302129
Koo H., Gomes B.P., Rosalen P.L., Ambrosano G.M., Park Y.K., Cury J.A. In vitro antimicrobial activity of propolis and Arnica montana against oral pathogens. Arch Oral Biol. 2000; 45 (2): 141-8. DOI: https://doi.org/10.1016/S0003-9969(99)00117-X
Felitti R. Propóleo en Odontología. Usos y aplicaciones. Actas Odontológicas (Publicación discontinuada). 2014; 11 (1): 30-7.
Bretz W.A., Chiego D.J., Jr., Marcucci M.C., Cunha I., Custódio A., Schneider L.G. Preliminary report on the effects of propolis on wound healing in the dental pulp. Z Naturforsch C J Biosci. 1998; 53 (11-12): 1045-8. DOI: https://doi.org/10.1515/znc-1998-11-1217
Bruschi M.L., Jones D.S., Panzeri H., Gremião M.P.D., de Freitas O., Lara E.H.G. Semisolid systems containing propolis for the treatment of periodontal disease: In Vitro release kinetics, syringeability, rheological, textural, and mucoadhesive properties. Journal of Pharmaceutical Sciences. 2007; 96 (8): 2074-89. DOI: https://doi.org/10.1002/jps.20843
Costalonga M., Herzberg M.C. The oral microbiome and the immunobiology of periodontal disease and caries. Immunol Lett. 2014; 162 (2 Pt A): 22-38. DOI: https://doi.org/10.1016/j.imlet.2014.08.017
Camargo M.B.F. Periodoncia. Fundamentos de Odontología. 2 ed2007.
Lang L.K. Periodontología Clínica e Implantología Odontológica. 4 ed2003.
Glavind L., Löe H. Errors in the clinical assessment of periodontal destruction. Journal of periodontal Research. 1967; 2 (3): 180-4. DOI: https://doi.org/10.1111/j.1600-0765.1967.tb01887.x
Ainamo J., Bay I. Problems and proposals for recording gingivitis and plaque. International dental journal. 1975; 25 (4): 229.
Mühlemann HRaS, S. Gingival Sulcus Bleeding-A Leading Symptom in Initial Gingivitis. . Helvetica Odontologica Acta. 1971; 15: 107-13.
Russell A. A system of classification and scoring for prevalence surveys of periodontal disease. Journal of Dental Research. 1956; 35 (3): 350-9. DOI: https://doi.org/10.1177/00220345560350030401
Almeida V.S.M., Azevedo J., Leal H.F., Queiroz A.T.L., da Silva Filho H.P., Reis J.N. Bacterial diversity and prevalence of antibiotic resistance genes in the oral microbiome. PLoS One. 2020; 15 (9): e0239664. DOI: https://doi.org/10.1371/journal.pone.0239664
El-Sharkawy H.M., Anees M.M., Van Dyke T.E. Propolis Improves Periodontal Status and Glycemic Control in Patients With Type 2 Diabetes Mellitus and Chronic Periodontitis: A Randomized Clinical Trial. J Periodontol. 2016; 87 (12): 1418-26.
Coutinho A. Honeybee propolis extract in periodontal treatment: A clinical and microbiological study of propolis in periodontal treatment. Indian Journal of Dental Research. 2012; 23 (2): 294.
Kumar A., Sunkara M.S., Pantareddy I., Sudhakar S. Comparison of plaque inhibiting efficacies of Aloe vera and propolis tooth gels: A randomized PCR study. Journal of clinical and diagnostic research: JCDR. 2015; 9 (9): ZC01. DOI: https://doi.org/10.7860/JCDR/2015/13185.6413
de Andrade D.P., Carvalho I.C.S., Godoi B.H., Rosa L.C.L., Barreto L.M.R.C., Pallos D. Subgingival Irrigation with a Solution of 20% Propolis Extract as an Adjunct to Non-Surgical Periodontal Treatment: A Preliminary Study. Journal of the International Academy of Periodontology. 2017; 19 (4): 145-51.
Moher D., Liberati A., Tetzlaff J., Altman D.G., The P.G. Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. PLOS Medicine. 2009; 6 (7): e1000097. DOI: https://doi.org/10.1371/journal.pmed.1000097
Gebaraa E.C., Pustiglioni A.N., de Lima L.A., Mayer M.P. Propolis extract as an adjuvant to periodontal treatment. Oral health & preventive dentistry. 2003; 1 (1): 29-35.
Coutinho A. Honeybee propolis extract in periodontal treatment: a clinical and microbiological study of propolis in periodontal treatment. Indian journal of dental research: official publication of Indian Society for Dental Research. 2012; 23 (2): 294. DOI: https://doi.org/10.4103/0970-9290.100449
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, et al. Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. Journal of Periodontology. 2018; 89 (S1): S74-S84. DOI: https://doi.org/10.1002/JPER.17-0719
Shalaby H.K., Morsy S.M. Evaluation of adjunctive effect of daily dietary supplements with omega 3 and propolis to non-surgical periodontal therapy: Randomized Clinical Trial. Egyptian Dental Journal. 2019;65(4-October (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)): 3543-53.
Shalaby H., Morsy S. Evaluation of adjunctive effect of daily dietary supplements with omega 3 and propolis to non-surgical periodontal therapy: Randomized Clinical Trial. Egyptian Dental Journal. 2019; 65: 3543-53. DOI: https://doi.org/10.21608/edj.2019.74811
Sanghani N.N., Shivaprasad B., Savita S. Health from the hive: propolis as an adjuvant in the treatment of chronic periodontitis-a clinicomicrobiologic study. Journal of clinical and diagnostic research: JCDR. 2014; 8 (9): ZC41.
El Sharkawy H.M., Anees M.M., Van Dyke T.E. Propolis improves periodontal status and glycemic control in patients with type 2 diabetes mellitus and chronic periodontitis: a randomized clinical trial. Journal of periodontology. 2016; 87 (12): 1418-26. DOI: https://doi.org/10.1902/jop.2016.150694
Andrade D.P., Carvalho I.C.S., Gadoi B.H., Rosa L.C.L., Barreto L., Pallos D. Subgingival Irrigation with a Solution of 20% Propolis Extract as an Adjunct to Non-Surgical Periodontal Treatment: A Preliminary Study. J Int Acad Periodontol. 2017;19 (4):145-51.
Smiley C.J., Tracy S.L., Abt E., Michalowicz B.S., John M.T., Gunsolley J., et al. Systematic review and meta-analysis on the nonsurgical treatment of chronic periodontitis by means of scaling and root planing with or without adjuncts. Journal of the American Dental Association (1939). 2015; 146 (7): 508-24.e5. DOI: https://doi.org/10.1016/j.adaj.2015.01.028
Gebara E.C.E., Pustiglioni A.N., de Lima L.A.P.A., Mayer M.P.A. Propolis extract as an adjuvant to periodontal treatment. Oral health & preventive dentistry. 2003; 1 (1).
Félix R-RJ. La utilidad del propóleo en las ciencias de la salud. Lux Médica. 2014: 29-35.
Elkhenany H., El-Badri N., Dhar M. Green propolis extract promotes in vitro proliferation, differentiation, and migration of bone marrow stromal cells. Biomedicine & pharmacotherapy=Biomedecine & pharmacotherapie. 2019;115:108861. DOI: https://doi.org/10.1016/j.biopha.2019.108861
Surek M., Fachi M.M., de Fátima Cobre A., de Oliveira FF, Pontarolo R, Crisma AR, et al. Chemical composition, cytotoxicity, and antibacterial activity of propolis from Africanized honeybees and three different Meliponini species. J Ethnopharmacol. 2021; 269: 113662. DOI: https://doi.org/10.1016/j.jep.2020.113662
Aranci K., Uzun M., Su S., Cesur S., Ulag S., Amin A., et al. 3D Propolis-Sodium Alginate Scaffolds: Influence on Structural Parameters, Release Mechanisms, Cell Cytotoxicity and Antibacterial Activity. Molecules. 2020; 25 (21). DOI: https://doi.org/10.3390/molecules25215082
Published
Issue
Section
License
Copyright (c) 2021 CC-BY-NC-SA 4.0
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
ODOVTOS - Int. J. Dent. Sc. endorses CC BY-NC-SA
This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator. If you remix, adapt, or build upon the material, you must license the modified material under identical terms. CC BY-NC-SA includes the following elements:
BY: credit must be given to the creator.
NC: Only noncommercial uses of the work are permitted.
SA: Adaptations must be shared under the same terms.
