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Rev. Biol. Trop. (Int. J. Trop. Biol.) • Vol. 69(1): 36-44, March 2021
A Synthetic Derivative of Antimicrobial Peptide
Holothuroidin 2 from Mediterranean Sea Cucumber
(Holothuria tubulosa) in the Control of Listeria
monocytogenes. Marine Drugs, 17(3), 1-11.
Ebrahimi, H., Vazirizadeh, A., Nabipour, I., Najafi, A.,
Tajbakhsh, S., & Nafisi Bahabadi, M. (2018). In vitro
study of antibacterial activities of ethanol , methanol
and acetone extracts from sea cucumber Holothu-
ria parva. Iranian Journal of Fisheries Sciences,
17(3), 542-551.
Fernández, M., Balmaseda, I., & Regueira, S. (2015).
Bioactivos marinos en el tratamiento del cáncer.
Revista Electronica Dr. Zolio E. Marinello Vidaurre-
ta, 40(7), 1-9.
Fuentes, E., Rodríguez-Pérez, W., Guzmán, L., Alarcón,
M., Navarrete, S., Forero-doria, O., & Palomo, I.
(2013). Mauritia flexuosa Presents In Vitro and
In Vivo Antiplatelet and Antithrombotic Activities.
Evidence-Based Complementary and Alternative
Medicine, 2013, 1-11.
Giménez, C. (1998). Composición y estructura de la
membrana neuronal : bases moleculares de su fisio-
logía y su patología. Revista de Neurología, 26(150),
232-239.
Goncalves, A.M.M., Mesquita, A.F., Verdelhos, T., Cout-
inho, J.A.P., Marques, J.C., & Goncalves, F. (2016).
Fatty acids’ profiles as indicators of stress induced
by of a common herbicide on two marine bivalves
species: Cerastoderma edule (Linnaeus , 1758) and
Scrobicularia plana (da Costa , 1778). Ecological
Indicators, 63(1), 657-672.
Guzmán, M., Quiroz, J., Angulo Ortiz, A., Torres, O., &
Santafé, G.G. (2014). Bioprospección e identifica-
ción de los ácidos grasos del pepino de mar Holothu-
ria floridana. Evodia, 1(1), 39-46.
Ibrahim, N.I., Wong, S.K., Mohamed, I.N., & Mohamed,
N. (2018). Wound Healing Properties of Selected
Natural Products. International Journal of Environ-
mental Research and Public Health, 15(11), 2360.
Ismail, H., Lemriss, S., Ben Aoun, Z., Mhadhebi, L.,
Dellai, A., Kacem, Y., … Bouraoui, A. (2008). Anti-
fungal activity of aqueous and methanolic extracts
from the Mediterranean sea cucumber, Holothuria
polii. Journal de Mycologie Medicale, 18(1), 23-26.
Martins, L. (2012). Estudo Taxonômico dos Holothuroidea
( Echinodermata ) de águas rasas da costa Brasilei-
ra. Salvador, Brasil: Universidade Federal da Bahia.
Mashjoor, S., & Yousefzadi, M. (2016). Holothurians anti-
fungal and antibacterial activity to human pathogens
in the Persian Gulf. Journal de Mycologie Medicale,
27(1), 46-56.
Mehmet, A., Sevgili, H., Tufan, B., Emre, Y., & Ko, S.
(2011). Proximate composition and fatty acid profile
of three different fresh and dried commercial sea
cucumbers from Turkey. International Journal of
Food Science & Technology, 46, 500-508.
Méndez, N., Angulo, A., & Contreras, O. (2016). Acti-
vidad antibacteriana in vitro de Curcuma longa
(Zingiberaceae) frente a bacterias nosocomiales en
Montería, Colombia. Revista de Biología Tropical,
64(3), 1201-1208.
Mohammadi, M., & Rohloff, J. (2016). Antibiofilm activity
of essential oils and plant extracts against Staphylo-
coccus aureus and Escherichia coli biofilms. Food
Control, 61, 156-164.
Nazemi, M., Moradi, Y., Mortazavi, M.S., Mohebbi Nozar,
S.L., Karimzadeh, R., & Ghaffari, H. (2020). Iso-
lation and identification of antibacterial compound
from common name Holothuria leucospilota in the
Persian Gulf. Iranian Journal of Fisheries Sciences,
19(5), 2493-2500.
Nisperuza-Pérez, C., Quirós-Rodríguez, J., & Solís-Marín,
F.A. (2019). Primeros registros e intervalos de dis-
tribución de Holothuria (Theelothuria) princeps
Selenka , 1867 (Echinodermata : Holothuroidea :
Holothuriidae ) en el golfo de Morrosquillo , Caribe
Colombiano. Revista de Biología Marina y Oceano-
grafía, 54(1), 139-143.
Pastrana Franco, O., Santafé Patiño, G., & Sánchez Rome-
ro, E. (2019). Perfil lipídico y ensayos de las activi-
dades antioxidante , insecticida y antialimentaria de
la esponja marina Iotrochota birotulata (Iotrochoti-
dae: Demospongiae ). Revista de Biología Tropical,
67, 213-223.
Pastrana, O., Santafé, G., & Quirós, J. (2016). Actividad
antioxidante del erizo de mar Mellita quinquies-
perforata (Leske) e identificación de sus compues-
tos lipídicos mayoritarios. Actualidades Biológicas,
38(104), 15-22.
Pérez, C., Santafé, G., Torres, M., Torres, O., Montaño, M.,
& Robledo, S. (2016). Composición lipídica y eva-
luación de las actividades antioxidante y leishmanici-
da del basidiomiceto Ganoderma sp . leishmanicidal
activities of the basidiomycete Ganoderma sp. Revis-
ta Cubana de Plantas Medicinales, 21(3), 318-331.
Pérez, M.J., Falqué, E., & Dominguez, H. (2016). Antimi-
crobial Action of Compounds from Marine Seaweed.
Marine Drugs, 14(3), 1-38.
Piñón, A., García, M., Mendiola, J., Pérez, A., & Monzote,
L. (2015). Evaluación in vitro de extractos de inver-
tebrados marinos frente a Leishmania amazonensis.
Revista Cubana de Medicina Tropical, 67(3), 1-8.
Purcell, S.W., Conand, C., Uthicke, S., & Byrne, M.
(2016). Ecological roles of exploited sea cucumbers.
Oceanografía y Biología Marina: Una Revisión
Anual, 54, 367-386.