Assessment of Serum Ferritin Levels and Periodontal Indices in Patients with Chronic Periodontitis Post/Pre Radiation Treatment of Head and Neck Cancer

Ahmed A. Al-Kubaisi; Abdulrahman Khalid Mssdf; Sameer A. Awad; Khalid H. Ibrahim; Mahmood Yaseen Mukhlif; Ekram R. Aldelaimi

doi:10.15517/kvtbk628

Authors

Ahmed A. Al-Kubaisi Department of Medical Laboratories Techniques, College of Health and Medical Technology, University of Al Maarif, Al Anbar, Iraq. Author https://orcid.org/0009-0002-6874-6346
Abdulrahman Khalid Mssdf Department of Clinical and Laboratory Science, College of Pharmacy, University of Anbar, Ramadi, Iraq. Author https://orcid.org/0009-0005-8859-8477
Sameer A. Awad Department of Medical Laboratories Techniques, College of Health and Medical Technology, University of Al Maarif, Al Anbar, Iraq. Author https://orcid.org/0000-0002-9194-719X
Khalid H. Ibrahim Abu Ghraib Hospital, Al-Karkh Health Directorate, Ministry of Health, Iraq. Author https://orcid.org/0009-0007-9872-1242
Mahmood Yaseen Mukhlif Department of Medical Laboratories Techniques, College of Health and Medical Technology, University of Al Maarif, Al Anbar, Iraq. Author https://orcid.org/0009-0004-9254-2380
Ekram R. Aldelaimi Department of Periodontology, Al-Anbar Health Directorate, Ministry of Health, Iraq. Author https://orcid.org/0009-0009-5890-6052

DOI:

https://doi.org/10.15517/kvtbk628

Keywords:

Head and neck cancer; Periodontal disease; Ferritin; Radiotherapy.

Abstract

Acute phase protein (APP) positivity is exhibited by ferritin in the presence of inflammation and chronic infections, such as periodontal disease. This study aims to investigate serum ferritin levels compared between post- and pre-radiation of periodontal disease with head and neck cancer PD+HNC. A total of 100 individuals in the present study were enrolled, comprising 50 patient’s periodontal disease (PD) with head and neck cancer who underwent radiotherapy post-six months (post-RT HNC) and 50 PD patients (pre-RT HNC). Probing pocket depth (PPD), clinical attachment level (CAL), gingival bleeding index (GBI), plaque index (PI), oral pH, and hyposalivation were noted. Serum ferritin levels were measured using an electrochemiluminescence immunoassay (eCLIA). A significantly higher percentage of ferritin levels was found in patients post-RT PD+HNC (301.90 ng/ml) contrasted to pre-RT PD+HNC (82.71 ng/ml) subjects. Serum ferritin levels were shown to be significantly positively correlated with CAL, PPD, PI, and GBI in subjects with chronic periodontitis. Receiver operating characteristic results of ferritin (area under the curve (AUC) =0.806 for post-RT PD+HNC, AUC=0.454 for pre-RT PD+HNC). It may be suggested that elevated serum ferritin levels in patients with post-RT PD+HNC have the potential to be evaluated as biomarkers for inflammation during periodontal tissue breakdown via radiation treatment.

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