Evaluación de los niveles séricos de ferritina e índices periodontales en pacientes con periodontitis crónica antes y después del tratamiento con radioterapia por cáncer de cabeza y cuello
DOI:
https://doi.org/10.15517/kvtbk628Palabras clave:
Cáncer de cabeza y cuello; Enfermedad periodontal; Ferritina; Radioterapia.Resumen
La ferritina, como proteína de fase aguda (APP), muestra positividad en presencia de inflamación e infecciones crónicas, como la enfermedad periodontal. Este estudio tiene como objetivo investigar los niveles séricos de ferritina en pacientes con enfermedad periodontal comparando entre el período posterior y previo a la radioterapia en cáncer de cabeza y cuello (PD+HNC). En total se incluyeron 100 individuos en el presente estudio: 50 pacientes con enfermedad periodontal y cáncer de cabeza y cuello que recibieron radioterapia después de seis meses (post-RT HNC) y 50 pacientes con enfermedad periodontal (pre-RT HNC). Se registraron la profundidad de sondaje periodontal (PPD), el nivel de inserción clínica (CAL), el índice de sangrado gingival (GBI), el índice de placa (PI), el pH oral y la hiposalivación. Los niveles séricos de ferritina se midieron mediante inmunoensayo por electroquimioluminiscencia (eCLIA). Se encontró un porcentaje significativamente mayor de niveles de ferritina en pacientes post-RT PD+HNC (301,90 ng/ml) en comparación con los sujetos pre-RT PD+HNC (82,71 ng/ml). Los niveles séricos de ferritina mostraron una correlación positiva significativa con CAL, PPD, PI y GBI en sujetos con periodontitis crónica. Los resultados de la curva característica operativa del receptor (ROC) para la ferritina mostraron un área bajo la curva (AUC) = 0,806 en post-RT PD+HNC y AUC = 0,454 en pre-RT PD+HNC. Se puede sugerir que los niveles elevados de ferritina sérica en pacientes post-RT PD+HNC tienen el potencial de ser evaluados como biomarcadores de inflamación durante la destrucción del tejido periodontal inducida por la radioterapia.
Descargas
Referencias
Statistics, E.G.C., GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 2020. 70 (4): p.313. DOI: https://doi.org/10.3322/caac.21609
Siegel, R.L., et al., Cancer statistics, 2023. CA: a cancer journal for clinicians, 2023. 73 (1): p.17-48. DOI: https://doi.org/10.3322/caac.21763
Saliem, S.S., et al., Pathogenesis of periodontitis-A potential role for epithelial-mesenchymal transition. Japanese Dental Science Review, 2022. 58: p.268-278. DOI: https://doi.org/10.1016/j.jdsr.2022.09.001
Bertolini, M. and D. Clark, Periodontal disease as a model to study chronic inflammation in aging. Geroscience, 2024. 46 (4): p.3695-3709. DOI: https://doi.org/10.1007/s11357-023-00835-0
Albukhalefah, A.K.M. and H.A.N. Nayyef, Association between biochemical lepetin and some biochemical markers in Iraqi patients with obesity and periodontal. Romanian Journal of Diabetes, Nutrition and Metabolic Diseases, 2024. 31 (1): p.569-586.
Kwon, T., I.B. Lamster, and L. Levin, Current concepts in the management of periodontitis. International dental journal, 2021. 71 (6): p.462-476. DOI: https://doi.org/10.1111/idj.12630
Gajjar, S., et al., Effect of serum ferritin levels in gingivitis and periodontitis patients before and after nonsurgical periodontal therapeutic intervention. Journal of Applied Pharmaceutical Science, 2023. 13 (11): p.152-160. DOI: https://doi.org/10.7324/JAPS.2023.147406
Karam, S.D. and D. Raben, Radioimmunotherapy for the treatment of head and neck cancer. The Lancet Oncology, 2019. 20 (8): p.e404-e416. DOI: https://doi.org/10.1016/S1470-2045(19)30306-7
Kutuk, T., et al., Interdisciplinary Collaboration in Head and Neck Cancer Care: Optimizing Oral Health Management for Patients Undergoing Radiation Therapy. Current Oncology, 2024. 31 (4): p.2092-2108. DOI: https://doi.org/10.3390/curroncol31040155
Moshtaha, W., Oral Complications of Dental Prosthetic for Patients after Chemotherapy and Radiotherapy Treatment. Dental Hypotheses, 2021. 12 (2): p.67-72. DOI: https://doi.org/10.4103/denthyp.denthyp_57_20
Costa, A.A., et al., The association between periodontitis and the impact of oral health on the quality of life of individuals with psoriasis and psoriatic arthritis. PloS one, 2024. 19 (6): p.e0301158. DOI: https://doi.org/10.1371/journal.pone.0301158
Irie, M.-S., et al., Periodontal therapy for patients before and after radiotherapy: A review of the literature and topics of interest for clinicians. Medicina oral, patologia oral y cirugia bucal, 2018. 23 (5): p.e524. DOI: https://doi.org/10.4317/medoral.22474
Pal, P.P., et al., New natural pro-inflammatory cytokines (TNF-α, IL-6 and IL-1β) and iNOS inhibitors identified from Penicillium polonicum through in vitro and in vivo studies. International Immunopharmacology, 2023. 117: p.109940. DOI: https://doi.org/10.1016/j.intimp.2023.109940
Zia, A., et al., Oral biomarkers in the diagnosis and progression of periodontal diseases. Biology and Medicine, 2011. 3 (2): p.45-52.
Powanda, M.C. and E.D. Moyer, A brief, highly selective history of acute phase proteins as indicators of infection, inflammation and injury. Inflammopharmacology, 2021. 29 (3): p.897-901. DOI: https://doi.org/10.1007/s10787-021-00820-z
Uppal, S.S., et al., Ten years of clinical experience with adult onset Still’s disease: is the outcome improving? Clinical rheumatology, 2007. 26: p.1055-1060. DOI: https://doi.org/10.1007/s10067-006-0440-x
Sudarev, V.V., et al., Ferritin self-assembly, structure, function, and biotechnological applications. International journal of biological macromolecules, 2023. 224: p.319-343. DOI: https://doi.org/10.1016/j.ijbiomac.2022.10.126
Chow, J.K., et al., Increased serum iron levels and infectious complications after liver transplantation. Clinical Infectious Diseases, 2010. 51 (3): p.e16-e23. DOI: https://doi.org/10.1086/654802
Sandnes, M., et al., Hyperferritinemia-a clinical overview. Journal of Clinical Medicine, 2021. 10 (9): p.2008. DOI: https://doi.org/10.3390/jcm10092008
Caudell, J.J., et al., Head and neck cancers, version 1.2022 featured updates to the NCCN guidelines. JNCCN Journal of the National Comprehensive Cancer Network, 2022. 20 (3): p.225-234.
Mohd Noh, N.Z. and E. Noor, Gingival recession at a glance. BDJ Student, 2024. 31 (2): p.64-65. DOI: https://doi.org/10.1038/s41406-024-1380-0
Barnes, C.M., et al., Comparison of irrigation to floss as an adjunct to tooth brushing: effect on bleeding, gingivitis, and supragingival plaque. Journal of Clinical Dentistry, 2005. 16 (3): p.71.
Gil-Montoya, J.A., et al., Oral and general health conditions involved in periodontal status during pregnancy: A prospective cohort study. Archives of Gynecology and Obstetrics, 2023. 308 (6): p.1765-1773. DOI: https://doi.org/10.1007/s00404-022-06843-3
Tonetti, M.S., H. Greenwell, and K.S. Kornman, Staging and grading of periodontitis: Framework and proposal of a new classification and case definition. Journal of periodontology, 2018. 89: p.S159-S172. DOI: https://doi.org/10.1002/JPER.18-0006
Ahmad Akhoundi, M., et al., Urokinase-plasminogen activator protects periodontal ligament fibroblast from oxidative induced-apoptosis and DNA damage. Journal of Periodontal Research, 2018. 53 (5): p.861-869. DOI: https://doi.org/10.1111/jre.12576
Al-Kubaisi, A.A., et al., Soluble urokinase plasminogen activator receptor (suPAR) is a potential biomarker of stage III-IV, grade C periodontitis through the impact of post-radiotherapy on head and neck cancer patients. BMC Oral Health, 2024. 24 (1): p.1144. DOI: https://doi.org/10.1186/s12903-024-04801-w
Al-Kubaisi, A.A., et al., Changes and Roles of IL-6, hsCRP, and proCT in Patients with Chronic Periodontitis in Head and Neck Cancer Pre/Post Radiotherapy. Al-Rafidain Journal of Medical Sciences (ISSN 2789-3219), 2024. 7 (1): p.248-254. DOI: https://doi.org/10.54133/ajms.v7i1.1248
Huang, W., et al., Up-regulated ferritin in periodontitis promotes inflammatory cytokine expression in human periodontal ligament cells through transferrin receptor via ERK/P38 MAPK pathways. Clinical Science, 2019. 133 (1): p.135-148. DOI: https://doi.org/10.1042/CS20180679
Huang, W., et al., Ferritin expression in the periodontal tissues of primates. European Journal of Histochemistry: EJH, 2019. 63 (3). DOI: https://doi.org/10.4081/ejh.2019.3046
Faramarzi, M., et al., The effect of adjunctive use of melatonin as a supplement on serum ferritin level in periodontal patients: A randomized, controlled trial. Dental Research Journal, 2021. 18 (1): p.39. DOI: https://doi.org/10.4103/1735-3327.316656
Tiwana, M., et al., Whole saliva physico-biochemical changes and quality of life in head and neck cancer patients following conventional radiation therapy: a prospective longitudinal study. Indian journal of cancer, 2011. 48 (3): p.289-295. DOI: https://doi.org/10.4103/0019-509X.84918
Pontes, C.d.B., A.C.M. Polizello, and A.C.C. Spadaro, Clinical and biochemical evaluation of the saliva of patients with xerostomia induced by radiotherapy. Brazilian oral research, 2004. 18: p.69-74. DOI: https://doi.org/10.1590/S1806-83242004000100013
Sroussi, H.Y., et al., Common oral complications of head and neck cancer radiation therapy: mucositis, infections, saliva change, fibrosis, sensory dysfunctions, dental caries, periodontal disease, and osteoradionecrosis. Cancer medicine, 2017. 6 (12): p.2918-2931. DOI: https://doi.org/10.1002/cam4.1221
Hommez, G.M., et al., Effect of radiation dose on the prevalence of apical periodontitis-a dosimetric analysis. Clinical oral investigations, 2012. 16: p.1543-1547. DOI: https://doi.org/10.1007/s00784-011-0665-1
Laheij, A.M. and J.J. de Soet, Can the oral microflora affect oral ulcerative mucositis? Current opinion in supportive and palliative care, 2014. 8 (2): p.180-187. DOI: https://doi.org/10.1097/SPC.0000000000000053
Descargas
Publicado
Número
Sección
Licencia
Derechos de autor 2025 Ahmed A. Al-Kubaisi, Abdulrahman Khalid Mssdf, Sameer A. Awad, Khalid H. Ibrahim, Mahmood Yaseen Mukhlif, Ekram R. Aldelaimi.
Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-CompartirIgual 4.0.
ODOVTOS - Int. J. Dent. Sc. endorses CC BY-NC-SA
This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator. If you remix, adapt, or build upon the material, you must license the modified material under identical terms. CC BY-NC-SA includes the following elements:
BY: credit must be given to the creator.
NC: Only noncommercial uses of the work are permitted.
SA: Adaptations must be shared under the same terms.
