Assessment of Serum Ferritin Levels and Periodontal Indices in Patients with Chronic Periodontitis Post/Pre Radiation Treatment of Head and Neck Cancer

Ahmed A. Al-Kubaisi; Abdulrahman Khalid Mssdf; Sameer A. Awad; Khalid H. Ibrahim; Mahmood Yaseen Mukhlif; Ekram R. Aldelaimi

doi:10.15517/kvtbk628

Autores/as

Ahmed A. Al-Kubaisi Department of Medical Laboratories Techniques, College of Health and Medical Technology, University of Al Maarif, Al Anbar, Iraq. Autor/a https://orcid.org/0009-0002-6874-6346
Abdulrahman Khalid Mssdf Department of Clinical and Laboratory Science, College of Pharmacy, University of Anbar, Ramadi, Iraq. Autor/a https://orcid.org/0009-0005-8859-8477
Sameer A. Awad Department of Medical Laboratories Techniques, College of Health and Medical Technology, University of Al Maarif, Al Anbar, Iraq. Autor/a https://orcid.org/0000-0002-9194-719X
Khalid H. Ibrahim Abu Ghraib Hospital, Al-Karkh Health Directorate, Ministry of Health, Iraq. Autor/a https://orcid.org/0009-0007-9872-1242
Mahmood Yaseen Mukhlif Department of Medical Laboratories Techniques, College of Health and Medical Technology, University of Al Maarif, Al Anbar, Iraq. Autor/a https://orcid.org/0009-0004-9254-2380
Ekram R. Aldelaimi Department of Periodontology, Al-Anbar Health Directorate, Ministry of Health, Iraq. Autor/a https://orcid.org/0009-0009-5890-6052

DOI:

https://doi.org/10.15517/kvtbk628

Palabras clave:

Cáncer de cabeza y cuello; Enfermedad periodontal; Ferritina; Radioterapia.

Resumen

La ferritina, como proteína de fase aguda (APP), muestra positividad en presencia de inflamación e infecciones crónicas, como la enfermedad periodontal. Este estudio tiene como objetivo investigar los niveles séricos de ferritina en pacientes con enfermedad periodontal comparando entre el período posterior y previo a la radioterapia en cáncer de cabeza y cuello (PD+HNC). En total se incluyeron 100 individuos en el presente estudio: 50 pacientes con enfermedad periodontal y cáncer de cabeza y cuello que recibieron radioterapia después de seis meses (post-RT HNC) y 50 pacientes con enfermedad periodontal (pre-RT HNC). Se registraron la profundidad de sondaje periodontal (PPD), el nivel de inserción clínica (CAL), el índice de sangrado gingival (GBI), el índice de placa (PI), el pH oral y la hiposalivación. Los niveles séricos de ferritina se midieron mediante inmunoensayo por electroquimioluminiscencia (eCLIA). Se encontró un porcentaje significativamente mayor de niveles de ferritina en pacientes post-RT PD+HNC (301,90 ng/ml) en comparación con los sujetos pre-RT PD+HNC (82,71 ng/ml). Los niveles séricos de ferritina mostraron una correlación positiva significativa con CAL, PPD, PI y GBI en sujetos con periodontitis crónica. Los resultados de la curva característica operativa del receptor (ROC) para la ferritina mostraron un área bajo la curva (AUC) = 0,806 en post-RT PD+HNC y AUC = 0,454 en pre-RT PD+HNC. Se puede sugerir que los niveles elevados de ferritina sérica en pacientes post-RT PD+HNC tienen el potencial de ser evaluados como biomarcadores de inflamación durante la destrucción del tejido periodontal inducida por la radioterapia.

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