Cannabis-Based Therapies for Chronic Orofacial Pain: A Systematic Review and Meta-Analysis

Cruz Moreno , Tatiana; Romero Guerrero, Maria; Quiguango Farias, Diego; Vélez Cevallos, Sandra; Pazmiño Troncoso, Eliana; Juiña Jaime, Alisson; Chauca Bajaña, Luis; Lorenzo-Pouso, Alejandro I.; Zambrano Aguilar, Héctor; Velásquez Ron, Byron

doi:10.15517/3e686644

Autores/as

Tatiana Cruz Moreno Carrera de Odontología , Universidad de Las Américas, Quito, Ecuador. Autor/a https://orcid.org/0009-0009-1685-6202
Maria Romero Guerrero Carrera de Odontología , Universidad de Las Américas, Quito, Ecuador. Autor/a https://orcid.org/0000-0001-8670-2529
Diego Quiguango Farias Carrera de Odontología , Universidad de Las Américas, Quito, Ecuador Autor/a https://orcid.org/0009-0006-2523-6687
Sandra Vélez Cevallos Carrera de Odontología , Universidad de Las Américas, Quito, Ecuador. Autor/a https://orcid.org/0000-0001-8202-3895
Eliana Pazmiño Troncoso Carrera de Odontología , Universidad de Las Américas, Quito, Ecuador. Autor/a https://orcid.org/0009-0004-0294-1418
Alisson Juiña Jaime Carrera de Odontología , Universidad de Las Américas, Quito, Ecuador. Autor/a https://orcid.org/0009-0000-4198-8033
Luis Chauca Bajaña Universidad de Guayaquil, Guayaquil, Ecuador. Autor/a https://orcid.org/0000-0002-8713-951X
Alejandro I. Lorenzo-Pouso Oral Medicine , Oral Surgery and Implantology Unit (Med Oral Res) Faculty Of Medicine and Dentistry , University of Santiago de Compostela,15782.Santiago de Compostela, Spain. Autor/a https://orcid.org/0000-0002-9180-4703
Héctor Zambrano Aguilar Carrera de Odontología , Universidad de Las Américas, Quito, Ecuador. Autor/a https://orcid.org/0000-0002-9993-1192
Byron Velasquez Ron Universidad de Las Américas (UDLA) Autor/a https://orcid.org/0000-0001-5660-3941

DOI:

https://doi.org/10.15517/3e686644

Palabras clave:

Cannabis; Cannabinoides; Dolor crónico; Dolor orofacial; Trastornos temporo mandibulares; Periodontitis; Cáncer oral; Analgésicos; Odontología; Revisión sistemática; Metaanálisis.

Resumen

Evaluar la eficacia de las terapias basadas en cannabis en el manejo del dolor crónico asociado con DTM, periodontitis y cáncer oral. El dolor orofacial crónico, especialmente en los trastornos temporomandibulares (DTM), supone un reto en la práctica dental. Los tratamientos tradicionales suelen tener efectos adversos y una eficacia limitada. El cannabis surge como una posible alternativa debido a sus propiedades analgésicas y antiinflamatorias. Se realizó una revisión sistemática y un metaanálisis de ensayos controlados aleatorizados, estudios de cohorte y casos y controles utilizando cinco bases de datos. El riesgo de sesgo se evaluó utilizando las herramientas Cochrane ROB 2.0 y ROBINS-I. Se incluyeron seis estudios. El cannabis mostró un alivio significativo del dolor en el cáncer oral (OR=1,46; IC 95%: 1,24-1,71), mientras que los efectos en las DTM y periodontitis fueron inconclusos. El cannabis puede beneficiar al manejo del dolor por cáncer oral; se necesitan más estudios sobre las DTM y la periodontitis.

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