Lesión verrucosa del paladar que simuló candidiasis y reveló un carcinoma escamoso oral bien diferenciado: Reporte de caso

Autores/as

DOI:

https://doi.org/10.15517/akbfw433

Palabras clave:

Carcinoma de células escamosas; Cavidad oral; Biopsia; Tomografía computarizada; Adulto mayor.

Resumen

El carcinoma de células escamosas oral (CIE 10 C05.0) es la neoplasia maligna más frecuente de la cavidad oral, con elevada mortalidad y pronóstico reservado. Su diagnóstico temprano es fundamental para mejorar la supervivencia, especialmente en adultos mayores. Se presenta el caso de una paciente femenina de 90 años que acudió a consulta por un “bulto en el paladar”. La evaluación clínica reveló una lesión ulcerada y verrucosa en el maxilar superior izquierdo, inicialmente tratada como candidiasis sin mejoría, lo que retrasó el diagnóstico definitivo y motivó la suspensión del uso de prótesis total. Se realizó una biopsia incisional, cuyo estudio histopatológico confirmó un carcinoma de células escamosas bien diferenciado, considerando como diagnóstico diferencial una hiperplasia pseudoepiteliomatosa reactiva. La tomografía mostró rebordes irregulares y compromiso óseo, hallazgos compatibles con la invasividad local del tumor. La evolución postoperatoria fue favorable y la paciente fue derivada a tratamiento oncológico mediante su seguro de salud. Este caso enfatiza la importancia de la correlación clínica, radiográfica e histopatológica en el diagnóstico de lesiones orales sospechosas, así como la necesidad de realizar biopsias tempranas en lesiones persistentes o progresivas, particularmente en adultos mayores portadores de prótesis dentales.

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Referencias

Johnson N.W., Jayasekara P., Amarasinghe A.A.H.K. Squamous cell carcinoma and precursor lesions of the oral cavity: epidemiology and aetiology. Periodontol 2000 [Internet]. 2011 Oct; 57 (1): 19-37. Available from: http://dx.doi.org/10.1111/j.1600-0757.2011.00401.x DOI: https://doi.org/10.1111/j.1600-0757.2011.00401.x

Adeoye J., Thomson P. A call for an established oral cancer classification by etiology and revision of related terminology. Oral Dis [Internet]. 2022 Apr; 28 (3): 840-2. Available from: http://dx.doi.org/10.1111/odi.13784 DOI: https://doi.org/10.1111/odi.13784

Tarle M., Lukšić I. Pathogenesis and Therapy of Oral Carcinogenesis. Int J Mol Sci [Internet]. 2024 Jun 8; 25 (12). Available from: http://dx.doi.org/10.3390/ijms25126343 DOI: https://doi.org/10.3390/ijms25126343

Romano A., Di Stasio D., Petruzzi M., Fiori F., Lajolo C., Santarelli A., et al. Noninvasive Imaging Methods to Improve the Diagnosis of Oral Carcinoma and Its Precursors: State of the Art and Proposal of a Three-Step Diagnostic Process. Cancers (Basel) [Internet]. 2021 Jun 8; 13 (12). Available from: http://dx.doi.org/10.3390/cancers13122864 DOI: https://doi.org/10.3390/cancers13122864

Lorini L., Bescós Atín C., Thavaraj S., Müller-Richter U., Alberola Ferranti M., Pamias Romero J., et al. Overview of Oral Potentially Malignant Disorders: From Risk Factors to Specific Therapies. Cancers (Basel) [Internet]. 2021 Jul 23; 13 (15). Available from: http://dx.doi.org/10.3390/cancers13153696 DOI: https://doi.org/10.3390/cancers13153696

Chen S.H., Hsiao S.Y., Chang K.Y., Chang J.Y. New Insights Into Oral Squamous Cell Carcinoma: From Clinical Aspects to Molecular Tumorigenesis. Int J Mol Sci [Internet]. 2021 Feb 24; 22 (5). Available from: http://dx.doi.org/10.3390/ijms22052252 DOI: https://doi.org/10.3390/ijms22052252

Vincent-Chong V.K. Editorial of Special Issue “Oral Cancer: From Pathophysiology to Novel Therapeutic Approaches.” Biomedicines [Internet]. 2023 Oct 11; 11 (10). Available from: http://dx.doi.org/10.3390/biomedicines11102748 DOI: https://doi.org/10.3390/biomedicines11102748

Fedele D.J., Jones J.A., Niessen L.C. Oral cancer screening in the elderly. J Am Geriatr Soc [Internet]. 1991 Sep; 39 (9): 920-5. Available from: http://dx.doi.org/10.1111/j.1532-5415.1991.tb04461.x DOI: https://doi.org/10.1111/j.1532-5415.1991.tb04461.x

Pindborg J.J. Oral cancer and precancer as diseases of the aged. Community Dent Oral Epidemiol [Internet]. 1978 Nov; 6 (6): 300-7. Available from: http://dx.doi.org/10.1111/j.1600-0528.1978.tb01171.x DOI: https://doi.org/10.1111/j.1600-0528.1978.tb01171.x

Wiseman S.M., Swede H., Stoler D.L., Anderson G.R., Rigual N.R., Hicks W.L. Jr., et al. Squamous cell carcinoma of the head and neck in nonsmokers and nondrinkers: an analysis of clinicopathologic characteristics and treatment outcomes. Ann Surg Oncol [Internet]. 2003 Jun;10 (5): 551-7. Available from: http://dx.doi.org/10.1245/aso.2003.09.010 DOI: https://doi.org/10.1245/ASO.2003.09.010

Wey P.D., Lotz M.J., Triedman L.J. Oral cancer in women nonusers of tobacco and alcohol. Cancer [Internet]. 1987 Oct 1 [cited 2025 Sep 5]; 60 (7): 1644-50. Available from: https://onlinelibrary.wiley.com/doi/abs/10.1002/1097-0142%2819871001%2960%3A7%3C1644%3A%3AAID-CNCR2820600737%3E3.0.CO%3B2-E

Rutkowska M., Hnitecka S., Nahajowski M., Dominiak M., Gerber H. Oral cancer: The first symptoms and reasons for delaying correct diagnosis and appropriate treatment. Adv Clin Exp Med [Internet]. 2020 Jun; 29 (6): 735-43. Available from: http://dx.doi.org/10.17219/acem/116753 DOI: https://doi.org/10.17219/acem/116753

Gorsky M., Silverman S. Jr. Denture wearing and oral cancer. J Prosthet Dent [Internet]. 1984 Aug; 52 (2): 164-6. Available from: http://dx.doi.org/10.1016/0022-3913(84)90088-x DOI: https://doi.org/10.1016/0022-3913(84)90088-X

Kindler S., Seebauer C., Mksoud M., Samietz S., Kocher T., Holtfreter B., et al. Impact of dental restorations and removable prostheses on potentially malignant oral mucosal disorders in the general population. J Prosthet Dent [Internet]. 2023 Jan; 129 (1): 89-95. Available from: http://dx.doi.org/10.1016/j.prosdent.2022.05.017 DOI: https://doi.org/10.1016/j.prosdent.2022.05.017

Webb B.C., Thomas C.J., Willcox M.D., Harty D.W., Knox K.W. Candida-associated denture stomatitis. Aetiology and management: a review. Part 2. Oral diseases caused by Candida species. Aust Dent J [Internet]. 1998 Jun; 43 (3): 160-6. Available from: http://dx.doi.org/10.1111/j.1834-7819.1998.tb00157.x DOI: https://doi.org/10.1111/j.1834-7819.1998.tb00157.x

Dağistan S., Aktas A.E., Caglayan F., Ayyildiz A., Bilge M. Differential diagnosis of denture-induced stomatitis, Candida, and their variations in patients using complete denture: a clinical and mycological study. Mycoses [Internet]. 2009 May; 52 (3): 266-71. Available from: http://dx.doi.org/10.1111/j.1439-0507.2008.01592.x DOI: https://doi.org/10.1111/j.1439-0507.2008.01592.x

Vadovics M., Ho J., Igaz N., Alföldi R., Rakk D., Veres É., et al. Candida albicans Enhances the Progression of Oral Squamous Cell Carcinoma and. mBio [Internet]. 2021 Feb 22; 13 (1): e0314421. Available from: http://dx.doi.org/10.1128/mBio.03144-21 DOI: https://doi.org/10.1128/mBio.03144-21

Mohd Bakri M., Mohd Hussaini H., Rachel Holmes A., David Cannon R., Mary Rich A. Revisiting the association between candidal infection and carcinoma, particularly oral squamous cell carcinoma. J Oral Microbiol [Internet]. 2010 Dec 21; 2. Available from: http://dx.doi.org/10.3402/jom.v2i0.5780 DOI: https://doi.org/10.3402/jom.v2i0.5780

Chiesa-Estomba C.M., Mayo-Yanez M., Vaira L.A., Maniaci A., Feng A.L., Landa-Garmendia M., et al. Oral Cavity Cancer Secondary to Dental Trauma: A Scoping Review. Biomedicines [Internet]. 2024 Sep 4; 12 (9). Available from: http://dx.doi.org/10.3390/biomedicines12092024 DOI: https://doi.org/10.3390/biomedicines12092024

Valente V.B., Takamiya A.S., Ferreira L.L., Felipini R.C., Biasoli É.R., Miyahara G.I., et al. Oral squamous cell carcinoma misdiagnosed as a denture-related traumatic ulcer: A clinical report. J Prosthet Dent [Internet]. 2016 Mar; 115 (3): 259-62. Available from: http://dx.doi.org/10.1016/j.prosdent.2015.08.024 DOI: https://doi.org/10.1016/j.prosdent.2015.08.024

Freitas J.B., Gomez R.S., De Abreu M.H.N.G., Ferreira E. Relationship between the use of full dentures and mucosal alterations among elderly Brazilians. J Oral Rehabil [Internet]. 2008 May; 35 (5): 370-4. Available from: http://dx.doi.org/10.1111/j.1365-2842.2007.01782.x DOI: https://doi.org/10.1111/j.1365-2842.2007.01782.x

Lin N.C., Hsu J.T., Tsai K.Y. Survival and clinicopathological characteristics of different histological grades of oral cavity squamous cell carcinoma: A single-center retrospective study. PLoS One [Internet]. 2020 Aug 25; 15 (8): e0238103. Available from: http://dx.doi.org/10.1371/journal.pone.0238103 DOI: https://doi.org/10.1371/journal.pone.0238103

Sharma G., Kamboj M., Narwal A., Devi A., Yadav J., Sharma M. Comparison of clinicopathological characteristics of young and old North Indian patients of oral squamous cell carcinoma. Oral Oncol Rep [Internet]. 2024 Sep; 11 (100615): 100615. Available from: https://linkinghub.elsevier.com/retrieve/pii/S2772906024004618 DOI: https://doi.org/10.1016/j.oor.2024.100615

Tsai M.R., Shieh D.B., Lou P.J., Lin C.F., Sun C.K. Characterization of oral squamous cell carcinoma based on higher-harmonic generation microscopy. J Biophotonics [Internet]. 2012 May; 5 (5-6): 415-24. Available from: http://dx.doi.org/10.1002/jbio.201100144 DOI: https://doi.org/10.1002/jbio.201100144

Hakim S.G., Wieker H., Trenkle T., Sieg P., Konitzer J., Holl-Ulrich K., et al. Imaging of mandible invasion by oral squamous cell carcinoma using computed tomography, cone-beam computed tomography and bone scintigraphy with SPECT. Clin Oral Investig [Internet]. 2014 Apr; 18 (3): 961-7. Available from: http://dx.doi.org/10.1007/s00784-013-1042-z DOI: https://doi.org/10.1007/s00784-013-1042-z

Lee S., Jang Y., Lee G., Jeon S., Kim D., Choi J. CT features of malignant and benign oral tumors in 28 dogs. Vet Radiol Ultrasound [Internet]. 2021 Sep; 62 (5): 549-56. Available from: http://dx.doi.org/10.1111/vru.12996 DOI: https://doi.org/10.1111/vru.12996

Publicado

2026-06-04