La era de la optogenética en el ámbito oral y maxilofacial
DOI:
https://doi.org/10.15517/42hxj398Palabras clave:
Optogenética; Genes; Cavidad oral; Maxilofacial.Resumen
La optogenética es un campo interdisciplinario que integra la genómica y la tecnología óptica para regular la expresión génica y diversos procesos biológicos. Esta técnica ofrece ventajas como el control preciso del momento y la localización de la activación, baja invasividad y una elevada eficiencia. El procedimiento se basa en proteínas fotosensibles que han sido modificadas genéticamente para cambiar su conformación al ser expuestas a la luz. Como resultado, las tecnologías optogenéticas han permitido avances significativos en la comprensión de múltiples mecanismos biológicos, que abarcan desde procesos subcelulares y celulares hasta circuitos neuronales y patrones conductuales. Esta revisión aborda la evolución de la optogenética y los avances recientes en su aplicación en estudios del sistema estomatognático, específicamente en el ámbito oral y maxilofacial. Asimismo, se analiza el impacto de esta tecnología en investigaciones preclínicas. Aunque el alcance de las técnicas optogenéticas continúa ampliándose, persisten desafíos importantes para su implementación en el campo de la investigación odontológica y oral.
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Derechos de autor 2025 Nehad M. Abd-elmonsif, Sherif Gamal.
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