Eficacia de la fibrina rica en plaquetas inyectable, gel liberador de oxígeno y gel de ácido hialurónico como agentes de liberación local de fármacos en el tratamiento de la periodontitis crónica: estudio clínico-microbiológico
DOI:
https://doi.org/10.15517/dafg0q85Palabras clave:
Raspado dental; Ácido hialurónico; Bolsa periodontal; Periodontitis; Fibrina rica en plaquetas; Alisado radicular.Resumen
Este estudio evaluó clínica y microbiológicamente la eficacia del i-PRF líquido, el gel liberador de oxígeno y el gel de ácido hialurónico (HA) como agentes de liberación local de fármacos (LDD) coadyuvantes al raspado y alisado radicular (SRP) para el tratamiento de bolsas periodontales. Se realizó un ensayo clínico aleatorizado de boca dividida, en 12 pacientes con 80 bolsas periodontales (profundidad de 3-6 mm). Las bolsas se asignaron aleatoriamente a cuatro grupos: control (solo SRP), grupo experimental I (i-PRF + SRP), grupo II (gel liberador de oxígeno + SRP) y grupo III (gel de HA + SRP). Las muestras de placa se analizaron para espiroquetas mediante microscopía de campo oscuro al inicio, y a 1 y 3 meses posteriores al tratamiento. Otros indicadores primarios evaluados fueron el índice de placa (PI), índice gingival (GI), profundidad de sondaje (PPD), nivel de inserción clínica (CAL) y recesión gingival (GR), medidos con una sonda UNC-15. Las pruebas estadísticas empleadas incluyeron la prueba de Bonferroni para comparaciones intragrupo, la prueba t pareada, el análisis de varianza de medidas repetidas (ANOVA) y la prueba t no pareada para comparaciones intergrupales. El análisis intragrupo mostró mejorías significativas en PI, GI, PPD, CAL y GR en todos los grupos (p<0.05). Las comparaciones intergrupales no revelaron diferencias significativas. Desde el punto de vista microbiológico, el i-PRF redujo significativamente las espiroquetas (p < 0.05), mientras que el gel liberador de oxígeno mostró resultados clínicos superiores (p<0.05). Todos los agentes de liberación local de fármacos demostraron un potencial terapéutico significativo. El gel liberador de oxígeno destacó clínicamente, mientras que el i-PRF fue superior desde el punto de vista antimicrobiano, lo que indica su potencial terapéutico para el tratamiento de bolsas periodontales.
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Derechos de autor 2026 Mansi Bansal, Manish Khatri, Deepali Mathur, Pratiksha Tripathi, Nisha Parveen, Nutan Tyagi.
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