Keywords
Periodontitis
Gingival crevicular fluid
How to Cite
Abstract
The destructive periodontal disease affects the tissues supporting the teeth, with the final result in the loss of it; so the research is directed towards identifying objective measures of risk such as biomarkers of destruction. Because studies of biomarkers present in the gingival crevicular fluid (FGC) have reported promising results, it is posible associated markers of tissue degradation with the progression of periodontal disease. The aim of this study is to determine the effect of nonsurgical periodontal treatment on the levels of pyridinoline in the FGC patients with chronic periodontitis. Materials and Methods: FGC samples (before and after treatment), both active and inactive sites determined by the method of tolerance, ICTP levels were measured using the ICTP EIA. Uni Q, the results were analyzed using Stata 7.0 program and the student-test for nonparametric samples Results: ICTP levels decreased significantly after performing non-surgical periodontal treatment (p = 0.0001). Conclusions: According to the results, the ICTP may be a good marker to monitor the effects of nonsurgical periodontal treatment.
References
Taba M., Kinney J., Kim A., Giannobile W. Diagnostic Biomarkers for Oral and Periodontal Diseases. Dent Clin N Am 2005; 49: 551-71.
Biomarkers Definitions Group. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther 2001; 69: 89-95.
Ozmeric N. Advances in periodontal disease markers. Clin Chim Acta 2004; 343: 1-16.
Zambon J. J., Nakamura M., Slots J. Effect of periodontal therapy on salivary enzymatic activity. J. Periodontal Res 1985; 20: 652-9.
Embery G., Waddington R. Gingival Crevicular Fluid: biological markers of periodontal tissue activity. Adv Dent Res 1994; 8: 329-336.
Eley B. M., Cox S. W. Proteolitic and hydrolytic enzymes from putative periodontal pathogens. Characterization, molecular genetics, effects pm host defences and tisues and detection in gingival crevicular fluid. Periodontol 2000 2003; 31:105-124.
Barros S., Williams R., Offenbacher S., Morrelli T. Gingival crevicular fluid as a source of biomarkers for periodontitis.Periodontology 2000, 2016: 70:53-64.
Narayanan A. S., Page R. C. Connective tissues of the periodontium: a summary of current work. Coll Relat Res 1983; 3 (1): 33-64.
Eriksen E. F., Charles P., Melsen F., et al. Serum markers of Type I collagen formation and degradation in metabolic bone disease: correlation with bone histomorphometry. J Bone Miner Res 1993; 8: 127-132.
Palys M. D., Haffajee A. D., Socransky S. S., et al. Relationship between C-telopeptide pyridinoline cross-links (ICTP) and putative periodontal pathogens in periodontitis. J. Clin Peridontol 1998; 25: 865-71.
Arikan F., Buduneli N., Lappin D. F. C-telopeptide pyridinoline crosslinks of type I collagen, soluble RANKL, and osteoprotegerin levels in crevicular fluid of dental implants with peri-implantitis: a case-control study. Int. J. Oral Maxillofac Implants. 2011 Mar-Apr; 26 (2): 282-9.
Oringer R. J., Palys M. D., Iranmanesh A, Fiorellini J. P., Haffajee A. D., Socransky S. S., Giannobile W. V. C-telopeptide pyridinoline cross-links (ICTP) and periodontal pathogens associated with endosseous oral implants. Clin Oral Implants Res. 1998 Dec; 9 (6): 365-73.
González J., Rivera S. Pyridinoline (ICTP) levels in Gingival Crevicular Fluid (GCF) in Chronic Periodontitis. Odovtos International Journal of Dental Sciences. 2016: 18: 3: 61-68.
Haffajee A. D., Socransky S., Goodson J. M. Clinical parameters as predictors of destructive periodontal disease activity. J. Clin Periodontol 1983; 10: 257-265.
Talonpoika J. T., Hamalainen M. M. Type I collagen carboxyterminal telopeptide in human gingival crevicular fluid in different clinical conditions and after periodontal treatment. J. Clin Periodontol. 1994 May; 21 (5): 320-6.
Golub L. M., Lee H. M., Greenwwald R. A., et al. A matrix metalloproteinase inhibitor reduces bone type collagen degradation fragments and specific collagenases in gingival crevicular fluid during adult periodontitis. Inflamm Res 1997; 46: 615-9.
Giannobile W. V., Lynch S. E., Denmark R. G. Crevicular fluid Osteocalcin and pyridiniline cross linked carboxyterminal telopeptide of type I collagen (ICTP) as markers of rapid bone turnover in periodontitis. A pilot study in beagle dogs. J. Clin Peridontol 1995; 22: 903-10.
Al-Shammari K. F., Giannobile W. V., Aldredge W. A., Iacono V. J., Eber R. M., Wang H. L., Oringer R. J. Effect of non-surgical periodontal therapy on C-telopeptide pyridinoline cross-links (ICTP) and interleukin-1 levels. J. Periodontol. 2001 Aug; 72 (8): 1045-51.
Khalaf F., Al-Shammari, Giannobile W.,et al. Effect of non-surgical periodontal therapy on c-telopeptide pyridinoline cross-links (ICTP) and interleukin-1 levels. J. Periodontol 2001; 72: 1045-51.