Keywords
Enfermedad periodontal; Peri-implantitis; Enfermedad peri-implantaria; Fluido crevicular gingival; Fluido de surco peri-implantario.
How to Cite
Abstract
It is stated that peri-implanter diseases have destructive effects similar to periodontal diseases. This study aims to compare IL-1β and TNF-α levels in healthy and diseased areas. Forty non-smokers systemically health individuals (40 implants/40 teeth) (age:38-67) were included in the study. In clinical and radiographic examinations; plaque index (PIn), gingival index (GI), periodontal pocket depth (PPD), clinical attachment level (CAL) and marginal bone loss (MBL) values were recorded. The gingival crevicular fluid (GCF) and peri-implanter sulcus fluids (PISF) of the patients were collected, and IL-1β and TNF-α levels were measured by ELISA in the samples. The collected data were analyzed with the help of SPSS v.22 package program. Sample PPD score showed a statistically significant difference between the diseased and healthy groups and also sample CAL showed statistically significant higher in Periodontitis(P) compared to periodontally heathy(H) and Gingivitis(G) (p>0.05). IL-1beta and TNF-α levels in GCF/PISF; In the P and Peri-implantitis (PI) group, it was found statistically significantly higher than the H, Healthy-Implant (HI), besides P showed higher levels compared to G (p<0.05). Within the limitations of our study, it can be said that IL-1β and TNF-α among inflammatory cytokines in GCF/PISF will increase in periodontal and peri-implanter diseases, it can also be said that this increase in cytokines may indicate that periodontal and peri-implanter diseases have similar immunological structure. Peri-implant mucositis without periodontitis history has similarity to peri-implantitis and periodontitis in terms of IL-1β and TNF-α levels in GCF/PISF.
References
Berglundh T., Armitage G., Araujo M.G., et al. Peri-implant diseases and conditions: Consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Periodontol 2018; 89: S313-S318.
Papapanou P.N., Sanz M., Buduneli N., et al. Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Periodontol 2018; 89: S173-S182.
Kinane D.F., Podmore M., Murray M.C., Hodge P.J., Ebersole J. Etiopathogenesis of periodontitis in children and adolescents. Periodontol 2000 2001; 26: 54-91.
Socransky S., Haffajee A. The Nature of Periodontal Diseases*. Ann Periodontol 1997.
Ghassib I., Chen Z., Zhu J., Wang H-L. Use of IL-1 β, IL-6, TNF-α, and MMP-8 biomarkers to distinguish peri-implant diseases: A systematic review and meta-analysis. Clin Implant Dent Relat Res 2019; 21 (1): 190-207.
Kinane D.F. Regulators of tissue destruction and homeostasis as diagnostic aids in periodontology. Periodontol 2000 2000; 24: 215-225.
Kantarci A., Hasturk H., Van Dyke T.E., Jenner E., Pasteur L. Host-mediated resolution of inflammation in periodontal diseases. Periodontol 2000 2006; 40 (81): 144-163.
Van Dyke T.E., Kornman K.S. Inflammation and factors that may regulate inflammatory response. J Periodontol 2008; 79 (8 Suppl): 1503-1507
Lang N.P., Kinane D.F., Lindhe J., Sanz M., Tonetti M.S. Sixth European Workshop on Periodontology of the European Academy of Periodontology at the Charterhouse at Ittingen, Thurgau, Switzerland. J Clin Periodontol 2008; 35 (8 Suppl): 1-2.
Taubman M.A., Kawai T. Involvement of T-lymphocytes in periodontal disease and in direct and indirect induction of bone resorption. Crit Rev Oral Biol Med 2001; 12 (2): 125-135.
Liu Y-C.G., Lerner U.H., Teng Y-T a. Cytokine responses against periodontal infection: protective and destructive roles. Periodontol 2000 2010;52(1):163-206.
Teles R.P., Gursky L.C., Faveri M., et al. Relationships between subgingival microbiota and GCF biomarkers in generalized aggressive periodontitis. J Clin Periodontol 2010; 37 (4): 313-323.
Hajishengallis G. Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response. Trends Immunol 2014; 35 (1): 3-11.
de Lima Oliveira A.P., de Faveri M., Gursky L.C., et al. Effects of periodontal therapy on GCF cytokines in generalized aggressive periodontitis subjects. J Clin Periodontol 2012; 39 (3): 295-302.
Gupta M., Chaturvedi R., Jain A. Role of monocyte chemoattractant protein-1 (MCP-1) as an immune-diagnostic biomarker in the pathogenesis of chronic periodontal disease. Cytokine 2013; 61 (3): 892-897.
Gündoğar H., Şenyurt S.Z., Erciyas K., Yalım M., Üstün K. The effect of low-level laser therapy on non-surgical periodontal treatment: a randomized controlled, single-blind, split-mouth clinical trial. Lasers Med Sci 2016; 31 (9).
Gürlek Ö., Gümüş P., Nile C.J., Lappin D.F., Buduneli N. Biomarkers and Bacteria Around Implants and Natural Teeth in the Same Individuals. J Periodontol 2017; 88 (8): 752-761.
Sorsa T., Gursoy U.K., Nwhator S., et al. Analysis of matrix metalloproteinases, especially MMP-8, in gingival crevicular fluid, mouthrinse and saliva for monitoring periodontal diseases. Periodontol 2000 2016; 70 (1): 142-163.
Faot F., Nascimento G.G., Bielemann A.M., Campão T.D., Leite F.R.M., Quirynen M. Can peri-implant crevicular fluid assist in the diagnosis of peri-implantitis? A systematic review and meta-analysis. J Periodontol 2015; 86 (5): 631-645.
Sanz M., Chapple I.L., Working Group 4 of the VIII European Workshop on Periodontology. Clinical research on peri-implant diseases: consensus report of Working Group 4. J Clin Periodontol 2012; 39: 202-206.
Aral C.A., Köseoğlu S., Sağlam M., Pekbağrıyanık T., Savran L. Gingival Crevicular Fluid and Salivary Periostin Levels in Non-Smoker Subjects With Chronic and Aggressive Periodontitis. Inflammation 2016; 39 (3): 986-993.
Heitz-Mayfield L.J.A., Lang N.P. Comparative biology of chronic and aggressive periodontitis vs. peri-implantitis. Periodontol 2000 2010; 53 (1): 167-181.
Munksgaard C. GCF IL-1b profiles in periodontal disease. 2002; 1: 48-53.
Petković A.B., Matić S.M., Stamatović N. V., et al. Proinflammatory cytokines (IL-1beta and TNF-alpha) and chemokines (IL-8 and MIP-1alpha) as markers of peri-implant tissue condition. Int J Oral Maxillofac Surg 2010; 39 (5): 478-485.
Casado P.L., Canullo L., de Almeida Filardy A., Granjeiro J.M., Barboza E.P., Leite Duarte M.E. Interleukins 1β and 10 expressions in the periimplant crevicular fluid from patients with untreated periimplant disease. Implant Dent 2013; 22 (2): 143-150.
Meyer S., Giannopoulou C., Courvoisier D., Schimmel M., Müller F., Mombelli A. Experimental mucositis and experimental gingivitis in persons aged 70 or over. Clinical and biological responses. Clin Oral Implants Res 2017; 28 (8): 1005-1012.
Newman M.G., Takei H., Klokkevold P.R., Carranza F.A. Carranza’s Clinical Periodontology.; 2014.
Sakai A., Ohshima M., Sugano N., Otsuka K., Ito K. Profiling the cytokines in gingival crevicular fluid using a cytokine antibody array. J Periodontol 2006; 77 (5): 856-864.
Engebretson S.P., Hey-Hadavi J., Ehrhardt F.J., et al. Gingival crevicular fluid levels of interleukin-1beta and glycemic control in patients with chronic periodontitis and type 2 diabetes. J Periodontol 2004; 75 (9): 1203-1208.
Schwarz F., Derks J., Monje A., Wang H-L. Peri-implantitis. J Periodontol. 2018; 89: S267-90.
Toia M., Stocchero M., Jinno Y., et al. Effect of Misfit at Implant-Level Framework and Supporting Bone on Internal Connection Implants: Mechanical and Finite Element Analysis. Int J Oral Maxillofac Implants 2019; 34 (2): 320-328.
Stadler A.F., Angst P.D.M., Arce R.M., Gomes S.C., Oppermann R.V., Susin C. Gingival crevicular fluid levels of cytokines/chemokines in chronic periodontitis: a meta-analysis. J Clin Periodontol 2016; 43 (9): 727-745.
Hattingh A., De Bruyn H., Vandeweghe S. A retrospective study on ultra-wide diameter dental implants for immediate molar replacement. Clin Implant Dent Relat Res 2019; 21 (5): 879-887.