Abstract
The purpose of this study was to determine the expression of periodontal disease within an extended costarican family.
A periodontal assessment was conducted by measuring pocket probing depths on 6 sites of all standing teeth, using a UNC-15 probe (Hu-Friedy, Chicago, USA). General medical and dental histories were also obtained and peripheral venous blood collected in order to determine serum cytokine levels and genetic polymorphisms. Ethical committee approval was obtained and all participants gave written informed consent.
All members of the family presented some degree of periodontal disease and those with more severe disease had alterations in IL-1α and the same IL-6 polymorphism. It is hypothesized that this may be related to the inflammatory status and levels of alveolar bone loss.
References
Baker Pamela J. Roopenian Derry C. Genetic susceptibility to chronic periodontal disease. Microbes and Infection 4 (2002) 1157–1167.
Bullon Fernandez, P.. Diagnóstico por el laboratorio de las enfermedades periodontales y periimplantarias: Diagnóstico de la periodontitis. Avances en Periodoncia [online]. 2004, vol.16, n.1 [citado 2009-07-19], pp. 35-45 .
Bernimoulin J-P: Conceptos recientes sobre formación de placa, Journal of Clinical Periodontology 2003; 30 (Suppl.5): 7-9.
Carranza Fermín A.; Takei Henry H.; Newman Michael G. Periodontología Clínica. 9 ed. México, Mc Graw- Hill Interamericana, 2004: 1044 pp
Echeverría A., Vignoletti F., Fabrizi S., Matesanz P., Papel etiológico de los virus en la enfermedad periodontal. Av Periodon Implantol. 2007; 19, 2:91-99.
Echevarria JJ. Enfermedades periodontales y periimplantarias. Factores de riesgo y su diagnóstico. Av Periodon Implantol. 2003;15: 149-58.
Graves D. Cytokines that promote periodontal tissue destruction. Journal of Periodontol 2008;79:1585-1591.
Graves. The Potential Role of Chemokines and Inflammatory Cytokines in Periodontal Disease Progression Journal of Clinical Infectious Diseases , 2001, pag. 482.490.
Gómez R, et al. El papel de la genética en la aparición y desarrollo de la periodontitis. I: evidencias científicas de la asociación entre periodontitis y genética. Av Periodon Implantol. 2007; 19, 2: 71- 83.
Hodge P.J. et al. Clinical and Genetic Analysis of a Large North European Caucasian Family Affected by Early-onset Periodontitis. 2000. J Dent Res 79(3): 857-863.
Kinane D F. Hart T C. Genes and gene polymorphics associated with periodontal disease. Crit Rev Oral Biol Med. 2003. 14(6):430- 449.
Pirkko J., Paju S., Mäntylä P., Sorsa T. Serum Microbial- and Host-Derived Markers of Periodontal Diseases: A Review Current Medicinal Chemistry, 2007, 14, 2402-2412.
Rioboo Crespo M. Bascones A. Factores de riesgo de la enfermedad periodontal: factores genéticos. Av Periodon Implantol. 2005; 17, 2: 69-77.
Schenkein Harvey. A. Finding genetic risk factors for periodontal diseases : is the climb worth the view? Periodontology 2000. Vol. 30. 2002. 79-90.
Seymour G . Cytokines in periodontal disease: where to from here? Oral Biology and Pathology, Acta Odontol Scand 2001; 59:167 –173.
Silva T.A. Chemokines in Oral Inflammatory Diseases: Apical Periodontitis and Periodontal Disease. J Dent Res, 2007, 86 (4): 306-319.
Spektor et al. “Clinical Studies of One Family manifesting Rapidly Progressive, Juvenile and Prepubertal Periodontitis”. 1984.
Sollecito, Thomas P. et al. Condiciones sistémicas asociadas con periodontitis en la infancia y la adolescencia: Una revisión de las posibilidades diagnósticas. Med. oral patol. oral cir. bucal. 2005, vol.10, n.2 pp. 142-150 .
Taboada. M E. Evaluación del Factor de Necrosis Tumoral (TNF-alfa) en pacientes peruanos con procesos periodontales. Odontol. Sanmarquina 2007; 10(1): 28-30.
Valderrama G. Vijande F., Escribano JM., Garrido-Pertierra A., Bascones A. La IL-1 y su eventual asociación con la enfermedad periodontal crónica. Una revisión de la literatura (I). Av Periodon Implantol. 2005; 17, 3: 157-163.