The purpose of this study was to determine the expression of periodontal disease within an extended costarican family.
A periodontal assessment was conducted by measuring pocket probing depths on 6 sites of all standing teeth, using a UNC-15 probe (Hu-Friedy, Chicago, USA). General medical and dental histories were also obtained and peripheral venous blood collected in order to determine serum cytokine levels and genetic polymorphisms. Ethical committee approval was obtained and all participants gave written informed consent.
All members of the family presented some degree of periodontal disease and those with more severe disease had alterations in IL-1α and the same IL-6 polymorphism. It is hypothesized that this may be related to the inflammatory status and levels of alveolar bone loss.