Keywords
Propóleo; Enfermedad periodontal; Periodontitis; Odontología; Antibacteriano; Antimicrobiano.
How to Cite
Abstract
The aim of this study was to determine the effect of propolis on non-surgical periodontal therapy in patients with chronic periodontitis (CP) as it appears in the recent literature. Propolis is a natural and biocompatible resinous substance that has shown, by means of several scientific studies, to possess medicinal properties such as antimicrobial, healing, anesthetic, anti-inflammatory, and analgesic, among others. There are several studies that have reported the use of propolis as a non-surgical treatment of CP, its comparison with other antimicrobials, and the improvement of clinical and microbiological parameters with scaling and root planing (SRP). A bibliographic search was conducted in the PubMed, Google Scholar, Web of Science, and Science Direct databases up to 2021. The results showed that there are very few reports focused on clinical studies; however, according to the analyzed data, propolis could be a good adjuvant for the treatment of patients with chronic periodontitis compared to the conventional treatment (SRP).
References
Zabaiou N., Fouache A., Trousson A., Baron S., Zellagui A., Lahouel M., et al. Biological properties of propolis extracts: Something new from an ancient product. Chem Phys Lipids. 2017; 207 (Pt B): 214-22.
Kędzia B. Pochodzenie propolisu w świetle teorii i badań naukowych. Herba Polonica. 2008; 54 (4): 179-86.
Jean-Prost P. Apicultura: conocimiento de la abeja. Manejo de la colmena: Mundi-Prensa Libros; 2007.
PERSANO A. Apicultura práctica Edit. Hemisferio Sur, Buenos Aires, argentina. 2008.
Rodríguez-Ramírez J.F., Delgado-Íñiguez F., De Velasco-Herrera P, Navarro-Hernández E, Madrigal-Elizalde E, Robles-Álvarez VM, et al. a utilidad del propóleo en las ciencias de la salud. Lux Médica. 2014; 9 (26): 31-8.
Sanchez M.F., Breda S.A., Soria E.A., Tártara L.I., Manzo R.H., Olivera M.E. Ciprofloxacin-lidocaine-based hydrogel: development, characterization, and in vivo evaluation in a second-degree burn model. Drug delivery and translational research. 2018; 8 (5): 1000-13.
Bonamigo T., Campos J.F., Alfredo T.M., Balestieri J.B.P., Cardoso C.A.L., Paredes-Gamero E.J., et al. Antioxidant, cytotoxic, and toxic activities of propolis from two native bees in Brazil: Scaptotrigona depilis and Melipona quadrifasciata anthidioides. Oxidative medicine and cellular longevity. 2017; 2017.
Boisard Sv, Le Ray A-M, Gatto J, Aumond M-C, Blanchard P, Derbré Sv, et al. Chemical composition, antioxidant and anti-AGEs activities of a French poplar type propolis. Journal of agricultural and food chemistry. 2014; 62 (6): 1344-51.
Park Y.K., Alencar S.M., Aguiar C.L. Botanical Origin and Chemical Composition of Brazilian Propolis. Journal of Agricultural and Food Chemistry. 2002; 50 (9): 2502-6.
da Silva Frozza C.O., Garcia C.S.C., Gambato G., de Souza M.D.O., Salvador M., Moura S., et al. Chemical characterization, antioxidant and cytotoxic activities of Brazilian red propolis. Food and chemical toxicology. 2013; 52: 137-42.
Bankova V.S., Castro SLd, Marcucci M.C. Propolis: recent advances in chemistry and plant origin. Apidologie. 2000; 31 (1): 3-15.
Petrova A., Popova M., Kuzmanova C., Tsvetkova I., Naydenski H., Muli E., et al. New biologically active compounds from Kenyan propolis. Fitoterapia. 2010; 81 (6): 509-14.
de Barros M.P., Sousa J.P., Bastos J.K., de Andrade S.F. Effect of Brazilian green propolis on experimental gastric ulcers in rats. J Ethnopharmacol. 2007; 110 (3): 567-71.
Salem M.M., Donia T., Abu-Khudir R., Ramadan H, Ali EMM, Mohamed TM. Propolis Potentiates Methotrexate Anticancer Mechanism and Reduces its Toxic Effects. Nutr Cancer. 2020; 72 (3): 460-80.
Rivero-Cruz J.F., Granados-Pineda J. Phytochemical Constituents, Antioxidant, Cytotoxic, and Antimicrobial Activities of the Ethanolic Extract of Mexican Brown Propolis. 2020; 9 (1).
Grange J.M., Davey R.W. Antibacterial properties of propolis (bee glue). J R Soc Med. 1990; 83 (3): 159-60.
de Carvalho Furtado Jr. J.H., Rocha Valadas L.A., Mendonça K.S., de Oliveira Filho R.D., Gadelha L.M., de Mello Fiallos N., et al. Propolis and its dental applications: a technological prospection. Recent patents on biotechnology. 2018; 12 (4): 288-96.
Dewhirst F.E., Chen T., Izard J., Paster B.J., Tanner A.C., Yu W.H., et al. The human oral microbiome. J Bacteriol. 2010; 192 (19): 5002-17.
Eguizábal M., Moromi Nakata H. Actividad antibacteriana in vitro del extracto etanólico de propóleo peruano sobre Streptococcus mutans y Lactobacillus casei. 2013.
Suyo J.A.D., de Casalino D.P. Actividad antibacteriana in vitro del extracto etanólico de propóleo de Oxapampa-Perú, sobre cepas de Porphyromonas gingivalis y Fusobacterium nucleatum. Revista Estomatológica Herediana. 2011; 21 (3): 125-30.
Almas K., Dahlan A., Mahmoud A. Propolis as a natural remedy: An update. 2001.
Momen-Beitollahi J., Mansorian A., Esmaili M., Amanlou M., Mohamadnia A., Bahrami N. Antimicrobial effects of propolis extract on the most prevalent oral pathogens: an in vitro study. Majallah i Dandanpizishki (Journal of Islamic Dental Association of Iran). 2009; 21 (1).
Scheller S., Ilewicz L., Luciak M., Skrobidurska D., Stojko A., Matuga W. Biological properties and clinical application of propolis. IX. Experimental observation on the influence of ethanol extract of propolis (EEP) on dental pulp regeneration. Arzneimittel-Forschung. 1978; 28 (2): 289-91.
Maekawa L.E., Valera M.C., Oliveira LDd, Carvalho C.A.T., Camargo C.H.R., Jorge A.O.C. Effect of Zingiber officinale and propolis on microorganisms and endotoxins in root canals. Journal of Applied Oral Science. 2013; 21 (1): 25-31.
Koo H., Gomes B.P., Rosalen P.L., Ambrosano G.M., Park Y.K., Cury J.A. In vitro antimicrobial activity of propolis and Arnica montana against oral pathogens. Arch Oral Biol. 2000; 45 (2): 141-8.
Felitti R. Propóleo en Odontología. Usos y aplicaciones. Actas Odontológicas (Publicación discontinuada). 2014; 11 (1): 30-7.
Bretz W.A., Chiego D.J., Jr., Marcucci M.C., Cunha I., Custódio A., Schneider L.G. Preliminary report on the effects of propolis on wound healing in the dental pulp. Z Naturforsch C J Biosci. 1998; 53 (11-12): 1045-8.
Bruschi M.L., Jones D.S., Panzeri H., Gremião M.P.D., de Freitas O., Lara E.H.G. Semisolid systems containing propolis for the treatment of periodontal disease: In Vitro release kinetics, syringeability, rheological, textural, and mucoadhesive properties. Journal of Pharmaceutical Sciences. 2007; 96 (8): 2074-89.
Costalonga M., Herzberg M.C. The oral microbiome and the immunobiology of periodontal disease and caries. Immunol Lett. 2014; 162 (2 Pt A): 22-38.
Camargo M.B.F. Periodoncia. Fundamentos de Odontología. 2 ed2007.
Lang L.K. Periodontología Clínica e Implantología Odontológica. 4 ed2003.
Glavind L., Löe H. Errors in the clinical assessment of periodontal destruction. Journal of periodontal Research. 1967; 2 (3): 180-4.
Ainamo J., Bay I. Problems and proposals for recording gingivitis and plaque. International dental journal. 1975; 25 (4): 229.
Mühlemann HRaS, S. Gingival Sulcus Bleeding-A Leading Symptom in Initial Gingivitis. . Helvetica Odontologica Acta. 1971; 15: 107-13.
Russell A. A system of classification and scoring for prevalence surveys of periodontal disease. Journal of Dental Research. 1956; 35 (3): 350-9.
Almeida V.S.M., Azevedo J., Leal H.F., Queiroz A.T.L., da Silva Filho H.P., Reis J.N. Bacterial diversity and prevalence of antibiotic resistance genes in the oral microbiome. PLoS One. 2020; 15 (9): e0239664.
El-Sharkawy H.M., Anees M.M., Van Dyke T.E. Propolis Improves Periodontal Status and Glycemic Control in Patients With Type 2 Diabetes Mellitus and Chronic Periodontitis: A Randomized Clinical Trial. J Periodontol. 2016; 87 (12): 1418-26.
Coutinho A. Honeybee propolis extract in periodontal treatment: A clinical and microbiological study of propolis in periodontal treatment. Indian Journal of Dental Research. 2012; 23 (2): 294.
Kumar A., Sunkara M.S., Pantareddy I., Sudhakar S. Comparison of plaque inhibiting efficacies of Aloe vera and propolis tooth gels: A randomized PCR study. Journal of clinical and diagnostic research: JCDR. 2015; 9 (9): ZC01.
de Andrade D.P., Carvalho I.C.S., Godoi B.H., Rosa L.C.L., Barreto L.M.R.C., Pallos D. Subgingival Irrigation with a Solution of 20% Propolis Extract as an Adjunct to Non-Surgical Periodontal Treatment: A Preliminary Study. Journal of the International Academy of Periodontology. 2017; 19 (4): 145-51.
Moher D., Liberati A., Tetzlaff J., Altman D.G., The P.G. Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. PLOS Medicine. 2009; 6 (7): e1000097.
Gebaraa E.C., Pustiglioni A.N., de Lima L.A., Mayer M.P. Propolis extract as an adjuvant to periodontal treatment. Oral health & preventive dentistry. 2003; 1 (1): 29-35.
Coutinho A. Honeybee propolis extract in periodontal treatment: a clinical and microbiological study of propolis in periodontal treatment. Indian journal of dental research: official publication of Indian Society for Dental Research. 2012; 23 (2): 294.
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, et al. Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. Journal of Periodontology. 2018; 89 (S1): S74-S84.
Shalaby H.K., Morsy S.M. Evaluation of adjunctive effect of daily dietary supplements with omega 3 and propolis to non-surgical periodontal therapy: Randomized Clinical Trial. Egyptian Dental Journal. 2019;65(4-October (Oral Medicine, X-Ray, Oral Biology & Oral Pathology)): 3543-53.
Shalaby H., Morsy S. Evaluation of adjunctive effect of daily dietary supplements with omega 3 and propolis to non-surgical periodontal therapy: Randomized Clinical Trial. Egyptian Dental Journal. 2019; 65: 3543-53.
Sanghani N.N., Shivaprasad B., Savita S. Health from the hive: propolis as an adjuvant in the treatment of chronic periodontitis-a clinicomicrobiologic study. Journal of clinical and diagnostic research: JCDR. 2014; 8 (9): ZC41.
El Sharkawy H.M., Anees M.M., Van Dyke T.E. Propolis improves periodontal status and glycemic control in patients with type 2 diabetes mellitus and chronic periodontitis: a randomized clinical trial. Journal of periodontology. 2016; 87 (12): 1418-26.
Andrade D.P., Carvalho I.C.S., Gadoi B.H., Rosa L.C.L., Barreto L., Pallos D. Subgingival Irrigation with a Solution of 20% Propolis Extract as an Adjunct to Non-Surgical Periodontal Treatment: A Preliminary Study. J Int Acad Periodontol. 2017;19 (4):145-51.
Smiley C.J., Tracy S.L., Abt E., Michalowicz B.S., John M.T., Gunsolley J., et al. Systematic review and meta-analysis on the nonsurgical treatment of chronic periodontitis by means of scaling and root planing with or without adjuncts. Journal of the American Dental Association (1939). 2015; 146 (7): 508-24.e5.
Gebara E.C.E., Pustiglioni A.N., de Lima L.A.P.A., Mayer M.P.A. Propolis extract as an adjuvant to periodontal treatment. Oral health & preventive dentistry. 2003; 1 (1).
Félix R-RJ. La utilidad del propóleo en las ciencias de la salud. Lux Médica. 2014: 29-35.
Elkhenany H., El-Badri N., Dhar M. Green propolis extract promotes in vitro proliferation, differentiation, and migration of bone marrow stromal cells. Biomedicine & pharmacotherapy=Biomedecine & pharmacotherapie. 2019;115:108861.
Surek M., Fachi M.M., de Fátima Cobre A., de Oliveira FF, Pontarolo R, Crisma AR, et al. Chemical composition, cytotoxicity, and antibacterial activity of propolis from Africanized honeybees and three different Meliponini species. J Ethnopharmacol. 2021; 269: 113662.
Aranci K., Uzun M., Su S., Cesur S., Ulag S., Amin A., et al. 3D Propolis-Sodium Alginate Scaffolds: Influence on Structural Parameters, Release Mechanisms, Cell Cytotoxicity and Antibacterial Activity. Molecules. 2020; 25 (21).