This study was carried out in order to determine the efficiency of paraquat and glyphosate herbicides mixed with four coadjutants for post-emergent weed control, as compared to mechanical control, as well as their economic feasibility. The study took place in Sierra de Arteaga, Coahuila, México. Information was collected 3, 13, 17, 31, and 83 days after application. A randomized block design with four repetitions was used. Glyphosato combined with adherent controlled 80% of weeds 83 days after application; glyphosate combined with moisturizer, and glyphosate combined with humic acid yielded 78.6 and 77.1% control respectively. Parquat mixed with humic acid controlled 88.4% 31 days after application and parquat mixed with adherent showed 75.1% control after 31 days. Overall, glyphosato combined with coadjutants showed better weed control 83 days after application. The cost of such treatment was $346.3 (Mexican currency), while the cost for the mechanical method was $810.00 (Mexican currency). The chemical method proved to be the most cost-efficient.