Diferencias individuales en modelos animales: un enfoque para el estudio de factores neurobiológicos relacionados con depresión

Sequeira Cordero, Andrey; Fornaguera Trías, Jaime

doi:10.15517/ap.v28i117.14115

Authors

Andrey Sequeira Cordero Instituto de Investigaciones en Salud Centro de Investigación en Neurociencias Escuela de Medicina Universidad de Costa Rica Author
Jaime Fornaguera Trías Instituto de Investigaciones en Salud Centro de Investigación en Neurociencia Escuela de Medicina Universidad de Costa Rica Author

DOI:

https://doi.org/10.15517/ap.v28i117.14115

Keywords:

Individual differences, forced swimming test, behavior, gene expression, brain

Abstract

The study of individual differences in the forced swimming test (FST) in rats allows the identification of either susceptibility or resilience factors in the development of depression-related behaviors. In order to study these differences several rat groups were subjected to the FST. Afterward, animals with low and high immobility were compared, which allowed us to identify a number of features that could function as risk or protection factors. Thus, neurobiological factors such as the expression levels of the corticotropin-releasing factor receptor 1 (CRFR1) in the nucleus accumbens, a differential accumbal dopamine turnover and the differential expression kinetics of the brain-derived neurotrophic factor (BDNF) in the prefrontal cortex, could play an important role in the modulation of depressive behaviors. The current review summarizes our key results in such research line.

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References

Aguilera, G., Nikodemova, M., Wynn, P.C., & Catt, KJ. (2004). Corticotropin releasing hormone receptors: two decades later. Peptides 25(3), 319-329. DOI: https://doi.org/10.1016/j.peptides.2004.02.002

Allis, C.D. (2006). Overview and concepts. In C.D.Allis, T. Jenuwein, & D. Reinberg (Eds.), Epigenetics (pp.23-62). New York, USA: Cold Spring Harbor Laboratory Press.

Andrade L., Caraveo-Anduaga J.J., Berglund P., Bijl R.V., De Graaf R., Vollebergh W., ...Wittchen HU.(2003). The epidemiology of major depressive episodes: results from the International Consortium DOI: https://doi.org/10.1002/mpr.138

of Psychiatric Epidemiology (ICPE) Surveys. International Journal of Methods in Psychiatric Research, 12, 3–21.

Armario, A., & Nadal, R. (2013). Individual differences and the characterization of animal models of psychopathology: a strong challenge and a good opportunity. Frontiers in Pharmacology, 4, 137. DOI: https://doi.org/10.3389/fphar.2013.00137

Arrant, A.E., Jemal, H., & Kuhn, C.M. (2013).Adolescent male rats are less sensitive than adults to the anxiogenic and serotonin-releasing effects of fenfluramine. Neuropharmacology, 65, 213-222. DOI: https://doi.org/10.1016/j.neuropharm.2012.10.010

Bennett, M.R. (2011). The prefrontal-limbic network in depression: Modulation by hypothalamus, basal ganglia and midbrain. Progress in Neurobiology, 93(4), 468-487. DOI: https://doi.org/10.1016/j.pneurobio.2011.01.006

Bilang-Bleuel, A., Ulbricht, S., Chandramohan, Y., De Carli, S., Droste, S.K., & Reul, J.M. (2005). Psychological stress increases histone H3 phosphorylation in adult dentate gyrus granule neurons: involvement in a glucocorticoid receptordependent behavioural response. European Journal of Neuroscience, 22(7), 1691-1700. DOI: https://doi.org/10.1111/j.1460-9568.2005.04358.x

Casey, B.J., Jones, R.M., &Hare, T.A. (2008). The adolescent brain. Annals of the New York Academy of Sciences, 1124, 111-126. DOI: https://doi.org/10.1196/annals.1440.010

Chandramohan, Y., Droste, S.K., Arthur, J.S., & Reul, J.M. (2008).The forced swimming-induced behavioural immobility response involves histone H3 phospho-acetylation and c-Fos induction in dentate gyrus granule neurons via activation of the N-methyl-D- spartate/extracellular signalregulated kinase/mitogen- and stress-activated kinase signalling pathway. European Journal of Neuroscience, 27(10), 2701-2713. DOI: https://doi.org/10.1111/j.1460-9568.2008.06230.x

Consejo Nacional de la Niñez y la Adolescencia. (2009). VII Estado de los derechos de la niñez y la adolescencia en Costa Rica.

Dalton, V.S., Kolshus, E., & McLoughlin, D.M. (2014). Epigenetics and depression: return of the repressed. Journal of Affective Disorders, 155, 1-12. DOI: https://doi.org/10.1016/j.jad.2013.10.028

Dipietro, J.A. (2012). Maternal stress in pregnancy: considerations for fetal development. Journal of Adolescent Health, 51(2 Suppl), S3-S8. DOI: https://doi.org/10.1016/j.jadohealth.2012.04.008

Harro, J. (2010). Inter-individual differences in neurobiology as vulnerability factors for affective disorders: implications for psychopharmacology. Pharmacology & Therapeutics, 125(3), 402-422. DOI: https://doi.org/10.1016/j.pharmthera.2009.11.006

Hirschfeld, R.M. (2001). The Comorbidity of Major Depression and Anxiety Disorders: Recognition and Management in Primary Care. The Primary Care Companion to the Journal of Clinical Psychiatry, 3(6), 244-254. DOI: https://doi.org/10.4088/PCC.v03n0609

Jankord, R., Solomon, M.B., Albertz, J., Flak, J.N., Zhang, R., & Herman, J.P. (2011). Stress vulnerability during adolescent development in rats. Endocrinology, 152(2), 629-638. DOI: https://doi.org/10.1210/en.2010-0658

Kaikkonen, M.U., Lam, M.T., & Glass, C.K. (2011). Noncoding RNAs as regulators of gene expression and epigenetics. Cardiovascular Research, 90(3), 430-440. DOI: https://doi.org/10.1093/cvr/cvr097

Kessler, R.C., Berglund, P., Demler, O., Jin, R., Koretz, D., Merikangas, K.R., … Wang, P.S. (2003). National Comorbidity Survey Replication. The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). JAMA, 289, 3095–3105. DOI: https://doi.org/10.1001/jama.289.23.3095

Lee, B.H., & Kim, Y.K. (2010). The roles of BDNF in the pathophysiology of major depression and in antidepressant treatment. Psychiatry Investigation, 7(4), 231-235. DOI: https://doi.org/10.4306/pi.2010.7.4.231

Lépine, J.P., & Briley, M. (2011). The increasing burden of depression. Journal of Neuropsychiatric Disease and Treatment, 7(Suppl 1), 3-7. DOI: https://doi.org/10.2147/NDT.S19617

Fattore, L., Piras, G., Corda, M.G., & Giorgi, O. (2009). The Roman high- and low-avoidance rat lines differ in the acquisition, maintenance, extinction, and reinstatement of intravenous cocaine self-administration. Neuropsychopharmacology, 34, 1091–1101. DOI: https://doi.org/10.1038/npp.2008.43

Grammatopoulos, D.K., & Chrousos, G.P. (2002). Functional characteristics of CRH receptors and potential clinical applications of CRH-receptor antagonists. Trends in Endocrinology & Metabolism, 13, 436–444. DOI: https://doi.org/10.1016/S1043-2760(02)00670-7

Lemos, J.C., Wanat, M.J., Smith, J.S., Reyes, B.A., Hollon, N.G., Van Bockstaele, E.J. & Phillips, P.E. (2012). Severe stress switches CRF action in the nucleus accumbens from appetitive to aversive. Nature, 490 (7420), 402-406. DOI: https://doi.org/10.1038/nature11436

Mandt, B.H., Allen, R.M., & Zahniser, N.R. (2009). Individual differences in initial low-dose cocaineinduced locomotor activity and locomotor sensitization in adult outbred female Sprague– Dawley rats. Pharmacology Biochemistry and Behavior, 91, 511–516. DOI: https://doi.org/10.1016/j.pbb.2008.09.002

Meaney, M.J., & Szyf, M. (2005). Environmental programming of stress responses through DNA methylation: life at the interface between a dynamic environment and a fixed genome. Dialogues in Clinical Neuroscience, 7 (2), 103-123. DOI: https://doi.org/10.31887/DCNS.2005.7.2/mmeaney

Moore, L.D., Le, T., & Fan, G. (2013). DNA methylation and its basic function. Neuropsychopharmacology, 38 (1), 23-38. DOI: https://doi.org/10.1038/npp.2012.112

Muschamp, J.W., Van’t Veer, A., Parsegian, A., Gallo, M.S., Chen, M., Neve, R.L., Carlezon, W.A. Jr. (2011). Activation of CREB in the nucleus accumbens shell produces anhedonia and resistance to extinction of fear in rats. Journal of Neuroscience, 31, 3095–3103. DOI: https://doi.org/10.1523/JNEUROSCI.5973-10.2011

Naudon, L., & Jay, T.M. (2005). Opposite behaviours in the forced swimming test are linked to differences in spatial working memory performances in the rat. Neuroscience, 130 (2), 285-293. DOI: https://doi.org/10.1016/j.neuroscience.2004.09.009

Pawlak, C.R., Ho, Y.J., & Schwarting, R.K. (2008). Animal models of human psychopathology based on individual differences in novelty-seeking and anxiety. Neuroscience & Biobehavioral Reviews, 2 (8), 1544-1568. DOI: https://doi.org/10.1016/j.neubiorev.2008.06.007

Peciña, S., Schulkin, J., & Berridge, K.C. (2006). Nucleus accumbens corticotropin-releasing factor increases cue-triggered motivation for sucrose reward: paradoxical positive incentive effects in stress? BMC Biology, 4, 8. DOI: https://doi.org/10.1186/1741-7007-4-8

Porsolt, R.D., Le Pichon, M., & Jalfre, M. (1977). Depression: a new animal model sensitive to antidepressant treatments. Nature, 266, 730–732. DOI: https://doi.org/10.1038/266730a0

Riggs, A.D., Martienssen, R.A., & Russo, V.E.A. (1996). Introduction. In V.E.A. Russo, R.A. Martienssen, A.D. Riggs, & A.D. Briggs AD (Eds.), Epigenetic mechanisms of gene regulation (pp. 1-4). New York: Cold Spring Harbor Laboratory Press, Cold Spring Harbor.

Rock, P.L., Roiser, J.P., Riedel, W.J., &Blackwell, A.D. (2013). Cognitive impairment in depression: a systematic review and meta-analysis. Psychological Medicine, 29, 1-12.

Rupniak, N.M. (2003). Animal models of depression: challenges from a drug development perspective. Behavioural Pharmacology, 14(5-6), 385-390.

Schneider, M. (2013). Adolescence as a vulnerable period to alter rodent behavior. Cell and Tissue Research, 354(1), 99-106. DOI: https://doi.org/10.1007/s00441-013-1581-2

Schwarting, R.K.W., Thiel, C.M., Muller, C.P., & Huston, J.P. (1998). Relationship between anxiety and serotonin in the ventral striatum. Neuroreport, 9, 1025–1029. DOI: https://doi.org/10.1097/00001756-199804200-00013

Sequeira A, & Fornaguera, J. (2009). Neurobiología de la depresión. Revista Mexicana de Neurociencias, 10(6), 462-478.

Sequeira-Cordero, A., Mora-Gallegos, A., Cuenca-Berger, P., & Fornaguera-Trías, J. (2013). Individual differences in the immobility behavior in juvenile and adult rats are associated with monoaminergic neurotransmission and with the expression of corticotropin-releasing factor receptor 1 in the nucleus accumbens. Behavioral Brain Research, 252, 77-87. DOI: https://doi.org/10.1016/j.bbr.2013.05.046

Sequeira-Cordero, A., Mora-Gallegos, A., Cuenca- Berger, P., & Fornaguera-Trías, J. (2014a). Individual differences in the forced swimming test and neurochemical kinetics in the rat brain. Physiology & DOI: https://doi.org/10.1016/j.physbeh.2014.01.037

Behavior, 128C, 60-69.

Sequeira-Cordero, A., Mora-Gallegos, A., Cuenca-Berger, P., & Fornaguera-Trías, J. (2014b). Individual differences in the forced swimming test and the effect of environmental enrichment: Searching for an interaction. Neuroscience, 265C, 95-107. DOI: https://doi.org/10.1016/j.neuroscience.2014.01.047

Shishkina, G.T., Kalinina, T.S., Berezova, I.V., Bulygina, V.V., & Dygalo, N.N. (2010). Resistance to the development of stress-induced behavioral despair in the forced swim test associated with elevated DOI: https://doi.org/10.1016/j.bbr.2010.05.003

hippocampal Bcl-xl expression. Behavioral Brain Research, 213 (2), 218-224.

Shumake, J., Barrett, D., & Gonzalez-Lima, F. (2005). Behavioural characteristics of rats predisposed to learned helplessness: reduced reward sensitivity, increased novelty seeking, and persistent fear DOI: https://doi.org/10.1016/j.bbr.2005.06.016

memories. Behav Brain Res, 164, 222–230.

Shumake, J., Edwards, E., & Gonzalez-Lima, F. (2002). Dissociation of septo-hippocampal metabolism in the congenitally helpless rat. Neuroscience, 114, 373–377. DOI: https://doi.org/10.1016/S0306-4522(02)00297-X

Shumake, J., Poremba, A., Edwards, E., & Gonzalez- Lima, F. (2000). Congenital helpless rats as a genetic model for cortex metabolism in depression. Neuroreport, 11, 3793–3798. DOI: https://doi.org/10.1097/00001756-200011270-00040

Simpson, J., & Kelly, J.P. (2011). The impact of environmental enrichment in laboratory rats: behavioural and neurochemical aspects. Behavioral Brain Research, 222(1), 246-264. DOI: https://doi.org/10.1016/j.bbr.2011.04.002

Slattery, D.A., & Cryan, J.F. (2012). Using the rat forced swim test to assess antidepressant-like activity in rodents. Nature Protocols, 7(6), 1009-1014. DOI: https://doi.org/10.1038/nprot.2012.044

Suganuma, T., & Workman, J.L. (2011). Signals and combinatorial functions of histone modifications. Annual Review of Biochemistry, 80, 473-499. DOI: https://doi.org/10.1146/annurev-biochem-061809-175347

Sun, M.K., & Alkon, D.L. (2008). Effects of age on susceptibility to the induction of depressive behavior and imipramine in rats. Behavioural Pharmacology, 19(4), 334-338. DOI: https://doi.org/10.1097/FBP.0b013e328308f239

Taghzouti, K., Lamarque, S., Kharouby, M., & Simon, H. (1999). Interindividual differences in active and passive behaviors in the forced-swimming test: implications for animal models of psychopathology. Biological Psychiatry, 45, 750-758. DOI: https://doi.org/10.1016/S0006-3223(98)00156-5

Topic, B., Oitzl, M.S., Meijer, O.C., Huston, J.P., &de Souza Silva, M.A. (2008). Differential susceptibility to extinctioninduced despair and age-dependent alterations in the hypothalamic-pituitary-adrenal axis and neurochemical parameters. Neuropsychobiology, 58 (3-4), 138-153. DOI: https://doi.org/10.1159/000182890

Vaissière, T., Sawan, C., & Herceg, Z. (2008). Epigenetic interplay between histone modifications and DNA methylation in gene silencing. Mutation Research, 659(1-2), 40-48. DOI: https://doi.org/10.1016/j.mrrev.2008.02.004

Villanueva, R. (2013). Neurobiology of major depressive disorder. Neural Plasticity, 2013, 873278. Doi:org/10.1155/2013/873278 DOI: https://doi.org/10.1155/2013/873278

Walsh, R.N., Cummins, R.A. (1976). The Open-Field Test: a critical review. Psychological Bulletin, 83 (3), 482-504. DOI: https://doi.org/10.1037/0033-2909.83.3.482

Weiss, J.M., Cierpial, M.A., &West, C.H. (1998). Selective breeding of rats for high and low motor activity in a swim test: toward a new animal model of depression. Pharmacology Biochemistry and Behavior, 61, 49–66. DOI: https://doi.org/10.1016/S0091-3057(98)00075-6

Yu, H., & Chen, Z.Y. (2011). The role of BDNF in depression on the basis of its location in the neural circuitry. Acta Pharmacologica Sinica, 32 (1), 3-11. DOI: https://doi.org/10.1038/aps.2010.184

Zhang, T.Y., & Meaney, M.J. (2010). Epigenetics and the environmental regulation of the genome and its function. Annual Review of Psychology, 61, 439-466. DOI: https://doi.org/10.1146/annurev.psych.60.110707.163625

Zhou, H., Hu, H., & Lai, M. (2010). Non-coding RNAs and their epigenetic regulatory mechanisms. Biology of the Cell, 102 (12), 645-655. DOI: https://doi.org/10.1042/BC20100029