The increase in traffic accidents in most countries of the world has triggered the alarms in urban and interurban mobility safety. Accidents occur both in public transport systems, such as private vehicles or mass transit systems. In this paper, the influence of road signage on users' road safety of the Transmilenio system in the main arterial of the Caracas Avenue in Bogotá, Colombia is studied through descriptive analysis and on-site inspection. The results show that it is urgent that national and municipal governments implement mitigation policies and measures aiming at decreasing socio-economic and psychological effects generated by motorized traffic