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© Odovtos International Journal of Dental Sciences, 2015
Patricia Lorz DDS
Universidad de Costa Rica Especialista en Patología y Cirugía Oral Pontificia Universidad Javeriana Docente Sección de Cirugía Oral y Maxilofacial de la Facultad de Odontología de la Universidad de Costa Rica Costa Rica
Rodolfo Varela DDS
DDS Universidad de Costa Rica Práctica privada en Clínica Dental Santa Bárbara Heredia Pasante Pasantía de Cirugía Oral Universidad de Costa Rica Costa Rica.
How to Cite
Role of the CTX Test for evaluation of the risk in diagnostic and treatment of the osteonecrosis of the jaws induced by the use of bisphosphonates
Vol 17 No 1 (2015): Odovtos - International Journal of Dental Sciences V.17, N.1 (JANUARY-APRIL)-2016
Published: Nov 29, 2015
A literature review was conducted to determine the effectiveness of the C-terminal crosslinking telopeptide (CTX) serologic test, which has been suggested to predict the risk of developing osteonecrosis of the jaw in patients taking oral bisphosphonates. Osteonecrosis of the jaw (ONJ) is a condition that causes avascular necrosis of the alveolar bone, which occurs in patients treated with bisphosphonates. It has been suggested that a CTX value below 100 pg/ml represents a high risk for ONJ , while between 100 and 150 pg / ml a moderate risk and above 150pg/ml minimal risk. The CTX test has been controversial and it has not been possible to frame it as strong evidence, since several studies have found variable results. Patients with very low CTX levels have not developed ONJ, and others with very high CTX levels, supposedly safe, have done . CTX test is a useful test to inform the dentist about the activity level on patient ́s bone turnover, and may be useful to advise the patient. Low CTX levels could serve to delay a surgical procedure that is not deemed urgent.