Odovtos - International Journal of Dental Sciences ISSN Impreso: 1659-1046 ISSN electrónico: 2215-3411

OAI: https://revistas.ucr.ac.cr/index.php/Odontos/oai
An Unusual Presentation of Clear Cell Odontogenic Carcinoma: Case Report


Clear cell odontogenic carcinoma
Clear cells
Biphasic pattern odontogenic.

How to Cite

Velazque DDS, MSc, L., Claudio DDS, MSc, PhD, C., & Pfuro, R. (2016). An Unusual Presentation of Clear Cell Odontogenic Carcinoma: Case Report. Odovtos - International Journal of Dental Sciences, 18(1), 33–39. https://doi.org/10.15517/ijds.v18i1.23484


Clear cell odontogenic carcinoma (CCOC) is a uncommon aggressive neoplasm of variable performance, which is primarily located in the mandibular anterior region, to a lesser extent in the maxilla, with prevalence in women between the fifth and seventh decades of life. Histologically it is constituted by networks of cells with clear cytoplasm mixed with cells containing eosinophilic cytoplasm rich in glycogen, surrounded by bands of collagen, you can make the local or distant metastases, highly recurrent, so it should include long-term follow-up patient and differentiated from other conditions with clear cell. The case of a male patient aged 52, with a mixed injury unusual presentation covering maxilla, zygomatic, orbital and right nasal cavity, without involvement of regional lymph nodes, no apparent metastases is reported.



Flores SAA, Morales JC, Sepúlveda RI, Romero EL. Carcinoma odontogénico de células claras. Rev Cubana Estomatol. 2013; 48 (1):69-76.

Maiorano E, Altini M, Viale G, Piattelli A, Favia G. Clear cell odontogenic carcinoma. Report of two cases and review of the literature. Am J Clin Pathol. 2001; 116:107-14.

August M, Faquin W, Troulis M, Kaban L. Clear cell odontogenic carcinoma: Evaluation of reported cases. J Oral Maxillofac Surg. 2003; 61:580-586.

Varma S, Shameena P, Sudha S, Nair RG, Varghese IV. Clear cell variant of intraosseous mucoepidermoid carcinoma: Report of a rare entity. J Oral Maxillofac Pathol. 2012; 16(1):141-144.

Falcón RE, Rodríguez RLF. Carcinoma odontogénico de células claras. Rev Electron Biomed / Electron J Biomed 2004; 2:46-55.

Kumar M, Fasanmade A, Barrett AW, Mack G, Newman L, Hyde NC. Metastasing clear cell odontogenic carcinoma: a case report and review of the literature. Oral Oncol. 2003; 39(2):190-194.

Navarro CV. Cirugía Oral. S.A. Aran Ediciones; 2008. pag. 441-450.

Swain N, Dhariwal R, Ray JG. Clear cell odontogenic carcinoma of maxilla: A case report and mini review. J Oral Maxillofac Pathol. 2013; 17(1): 89–94.

Loyola AM, Cardoso SV, de Faria PR, Servato JP, Barbosa de Paulo LF, Eisenberg AL et al. Clear cell odontogenic carcinoma: report of 7 new cases and systematic review of the current knowledge. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015; 120(4):483-496.

Goaz P, White S. Radiología oral, principios e interpretación. 3ª ed. Madrid: Mosby; 1995. pag. 477-493.

Regezi JA. Odontogenic cysts, odontogenic tumors, fibroosseous, and giant cell lesions of the jaws. Modern Pathology. 2002; 15(3):331.

Giglio M, Decano, Nicobsi L. Semiología en la práctica odontológica. Mcgraw-Hill / Interamericana de Chile, 2000. pag. 159.

Reichart PA, Philipsen HP. Odontogenic tumors and allied lesions. Quintessence Publishing. 2004. pag. 239-247.

Hansen LS, Eversole LR, Green TL, Powell NB. Clear cell odontogenic tumor – A new histologic variant with aggressive potential. Head Neck Surg. 1985; 8:115–123.

Waldron CA, Small IA, Silverman H. Clear cell ameloblastoma – An odontogenic carcinoma. J Oral Maxillofac Surg. 1985; 43:707–717.

Barnes L, Eveson JW, Reichart PA, Sidransky D. WHO Classification of Tumors, Pathology and Genetics of Head and Neck Tumours. Lyon, France: IARC Press; 2005. WHO histological classification of odontogenic tumours; pag. 284.

Neville BW, Damm DD, Allen CM, Bouquot JE. 3rd ed. Philadelphia, UK: WB Saunders; 2009. Odontogenic cysts and tumors. Oral and Maxillofacial Pathology; pag. 712–713.

Li TJ, Yu SF, Gao Y, Wang EB. Clear cell odontogenic carcinoma: A clinicopathologic and immunocytochemical study of 5 cases. Arch Pathol Lab Med. 2001; 125:1566–1571.

Chaine A, Pitak-Arnnop P, Dhanuthai K, Bertrand JC, Bertolus C. An asymptomatic radiolucent lesion of the maxilla. Clear cell odontogenic carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod.2009; 107:452–457.

Nair MK, Burkes EJ, Chai-U-Dom O. Radiographic manifestation of clear cell odontogenic tumor. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000; 89:250–254.

Walia C, Chatterjee RP, Kundu S, Roy S. Clinical enigma: A rare case of clear cell odontogenic carcinoma. Contemp Clin Dent. 2015; 6(4):559-63.

Kwon IJ, Kim SM, Amponsah EK, Myoung H, Lee JH, Lee SK. Mandibular clear cell odontogenic carcinoma. World J Surg Oncol. 2015; 24(13): 284.



Download data is not yet available.