Abstract
Introduction: Hyperparathyroidism is an endocrine disorder that could create parathyroid hormone hypersecretion conditions, propitious for bone tumors development. Although is not frequent, maxillary bones may be involved in the pathogenesis of these lesions. PATIENTS AND METHODS: In this case, a 56-year-old female is reported. An Hyperparathyroidism was diagnosed due to multiple maxillary and extra-maxillary multicentric bone lesions, with a predominance of giant cells, linked to her endocrine disorder. Discussion: The diagnosis of a Hyperparathyroidism Brown Tumor must meet serological, clinical and histopathological criteria. The multifocality of the lesions is the most remarkable clinical aspect in this case. For an adequate treatment of this entity is necessary an interdisciplinary and coordinate work between different areas of healthcare physicians and Oral Medicine specialist.
References
Fineman I., Johnson J. P., Di-Patre P. L., Sandhu H. Chronic renal failure causing brown tumors and myelopathy. Case report and review of pathophysiology and treatment. J. Neurosurg. 1999 Apr; 90 (2 Suppl): 242-6.
Leal C. T. S., Lacativa P. G. S., Gomes E. M.S., Nunes R. C., Costa F. L.F. de S., Gandelmann I. H. A., et al. Surgical approach and clinical outcome of a deforming brown tumor at the maxilla in a patient with secondary hyperparathyroidism due to chronic renal failure. Arq Bras Endocrinol Metabol. 2006 Oct; 50 (5): 963-7.
Pappu R., Jabbour S. A., Regianto A. M., Reginato A. J. Musculoskeletal manifestations of primary hyperparathyroidism. Clin Rheumatol. 2016 Dec; 35 (12): 3081-7.
Queiroz I. V., Queiroz S. P., Medeiros R., Ribeiro R. B., Crusoé-Rebello I. M., Leão J. C. Brown tumor of secondary hyperparathyroidism: surgical approach and clinical outcome. Oral Maxillofac Surg. 2016 Dec; 20 (4): 435-9.
Parra Ramírez P. A., Lecumberri Santamaría B., Álvarez Escolá C., Pallardo Sánchez L. F. Hiperparatiroidismo primario con osteítis fibrosa quística simulando una neoplasia ósea maligna. Endocrinol Nutr. 2013 Feb 1; 60 (2): 96-8.
Cytogenetic findings in a case of brown tumor associated with hyperparathyroidism [Internet]. Available from: https://www.researchgate.net/publication/12413295_Cytogenetic_findings_in_a_case_of_brown_tumor_associated_with_hyperparathyroidism
Chavin H. C., Pisarevsky A. A., Chavín C., Kroll L., Petrucci E. A. Tumor pardo como manifestación inicial de hiperparatiroidismo primario. Med B Aires. 2008 Jun; 68 (3): 219-21.
Aghaghazvini L., Sharifian H., Rasuli B. Primary Hyperparathyroidism Misdiagnosed as Giant Cell Bone Tumor of Maxillary Sinus: A Case Report. Iran J Radiol [Internet]. 2016. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841893/
Airaghi L., Pisano G., Pulixi E., Benti R., Baldini M. Unusual presentation in a case of primary hyperparathyroidism. J Res Med Sci Off J Isfahan Univ Med Sci. 2011 Aug;16 (8): 1078-81.
Triantafillidou K., Zouloumis L., Karakinaris G., Kalimeras E., Iordanidis F. Brown tumors of the jaws associated with primary or secondary hyperparathyroidism. A clinical study and review of the literature. Am J Otolaryngol. 2006 Aug; 27 (4): 281-6.
Baracaldo R. M., Bao D., Iampornpipopchai P., Fogel J., Rubinstein S. Facial disfigurement due to osteitis fibrosa cystica or brown tumor from secondary hyperparathyroidism in patients on dialysis: A systematic review and an illustrative case report. Hemodial Int Int Symp Home Hemodial. 2015 Oct;19 (4): 583-92.
Tarello F., Ottone S., De Gioanni P. P., Berrone S. Brown tumor of the jaws. Minerva Stomatol. 1996 Oct;45 (10): 465-70.
Gómez M. C., Riquelme P., Sirandoni G., Sapunar J., Princic E., Lee B. Brown tumors in multiple locations: manifestation of severe renal osteodystrophy. Case report. Rev Med Chil. 2003 Oct;131 (10):1183-7.
Jafari-Pozve N., Ataie-Khorasgani M., Jafari-Pozve S., Ataie-Khorasgani M. Maxillofacial brown tumors in secondary hyperparathyroidism: A case report and literature review. J Res Med Sci Off J Isfahan Univ Med Sci. 2014 Nov;19 (11): 1099-102.
Huang R., Zhuang R., Liu Y., Li T., Huang J. Unusual presentation of primary hyperparathyroidism: report of three cases. BMC Med Imaging. 2015 Jul 16;15:23.
Marcos garcía M., Pino Rivero V., Keituqwa yáñez T., Alcaraz Fuentes M., Trinidad ruiz G, Blasco huelva A. Tumor pardo óseo como primera manifestación de hiperparatiroidismo primario. OTORRI Acta Otorrinolaringol Espanola. 2003; 54 (6): 470-3.