Cho I., Blaser M. J. The human microbiome: at the interface of health and disease. Nature reviews Genetics. 2012; 13 (4): 260-70.
Silbergeld E. K. The Microbiome. Toxicologic pathology. 2017; 45 (1): 190-4.
Guerra F., Mazur M., Ndokaj A., Corridore D., La Torre G., Polimeni A., et al. Periodontitis and the microbiome: a systematic review and meta-analysis. Minerva stomatologica. 2018; 67 (6): 250-8.
Baker J. L., Bor B., Agnello M., Shi W., He X. Ecology of the Oral Microbiome: Beyond Bacteria. Trends in microbiology. 2017; 25 (5): 362-74.
Graves D.T., Correa J. D., Silva T. A. The Oral Microbiota Is Modified by Systemic Diseases. Journal of dental research. 2019; 98 (2): 148-56.
Sender R., Fuchs S., Milo R. Are We Really Vastly Outnumbered? Revisiting the Ratio of Bacterial to Host Cells in Humans. Cell. 2016; 164 (3): 337-40.
Kilian M. The oral microbiome - friend or foe? European journal of oral sciences. 2018; 126 Suppl 1: 5-12.
Marsh P.D. In Sickness and in Health-What Does the Oral Microbiome Mean to Us? An Ecological Perspective. Advances in dental research. 2018; 29 (1): 60-5.
Zhang Y., Wang X., Li H., Ni C., Du Z., Yan F. Human oral microbiota and its modulation for oral health. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018; 99: 883-93.
Krishnan K., Chen T., Paster B. J. A practical guide to the oral microbiome and its relation to health and disease. Oral diseases. 2017; 23 (3): 276-86.
Benn A., Heng N., Broadbent J. M., Thomson W. M. Studying the human oral microbiome: challenges and the evolution of solutions. Australian dental journal. 2018; 63 (1): 14-24.
Duran-Pinedo A. E., Frias-Lopez J. Beyond microbial community composition: functional activities of the oral microbiome in health and disease. Microbes and infection. 2015; 17 (7): 505-16.
Verma D., Garg P. K., Dubey A. K. Insights into the human oral microbiome. Archives of microbiology. 2018; 200 (4): 525-40.
Zarco M. F., Vess T. J., Ginsburg G. S. The oral microbiome in health and disease and the potential impact on personalized dental medicine. Oral diseases. 2012; 18 (2): 109-20.
Friedman E., Alizadeh N., Loewy Z. Oral Health: The Need for Both Conventional Microbial and Molecular Characterization. High-throughput. 2017; 6 (3).
Friedrich M. J. Microbiome project seeks to understand human body's microscopic residents. Jama. 2008; 300 (7): 777-8.
Kilian M., Chapple I. L., Hannig M., Marsh P. D., Meuric V., Pedersen A. M., et al. The oral microbiome - an update for oral healthcare professionals. British dental journal. 2016; 221 (10): 657-66.
Gao L., Xu T., Huang G., Jiang S., Gu Y., Chen F. Oral microbiomes: more and more importance in oral cavity and whole body. Protein & cell. 2018; 9 (5): 488-500.
Solbiati J. , Frias-Lopez J. Metatranscriptome of the Oral Microbiome in Health and Disease. Journal of dental research. 2018; 97 (5): 492-500.
Chen H., Jiang W. Application of high-throughput sequencing in understanding human oral microbiome related with health and disease. Frontiers in microbiology. 2014; 5: 508.
Moon J. H., Lee J. H. Probing the diversity of healthy oral microbiome with bioinformatics approaches. BMB reports. 2016; 49 (12): 662-70.
Rosier B. T., Marsh P. D., Mira A. Resilience of the Oral Microbiota in Health: Mechanisms That Prevent Dysbiosis. Journal of dental research. 2018; 97 (4): 371-80.
Renson A., Jones H. E., Beghini F., Segata N., Zolnik C. P., Usyk M., et al. Sociodemographic variation in the oral microbiome. Annals of epidemiology. 2019; 35: 73-80.e2.
Palmer R. J., Jr. Composition and development of oral bacterial communities. Periodontology 2000. 2014; 64 (1): 20-39.
He J., Li Y., Cao Y., Xue J., Zhou X. The oral microbiome diversity and its relation to human diseases. Folia microbiologica. 2015; 60 (1): 69-80.
McLean J. S. Advancements toward a systems level understanding of the human oral microbiome. Frontiers in cellular and infection microbiology. 2014; 4: 98.
Welch J. L. M., Dewhirst F. E., Borisy G. G. Biogeography of the Oral Microbiome: The Site-Specialist Hypothesis. Annual review of microbiology. 2019.
Proctor D. M., Fukuyama J. A., Loomer P. M., Armitage G. C., Lee S. A., Davis N. M., et al. A spatial gradient of bacterial diversity in the human oral cavity shaped by salivary flow. Nature communications. 2018; 9 (1): 681.
Bryan N. S., Tribble G., Angelov N. Oral Microbiome and Nitric Oxide: the Missing Link in the Management of Blood Pressure. Current hypertension reports. 2017; 19 (4): 33.
Xu P., Gunsolley J. Application of metagenomics in understanding oral health and disease. Virulence. 2014; 5 (3): 424-32.
Hall M. W., Singh N., Ng K. F., Lam D. K., Goldberg M. B., Tenenbaum H. C., et al. Inter-personal diversity and temporal dynamics of dental, tongue, and salivary microbiota in the healthy oral cavity. NPJ biofilms and microbiomes. 2017; 3: 2.
Cornejo Ulloa P., van der Veen M. H., Krom B. P. Review: modulation of the oral microbiome by the host to promote ecological balance. Odontology. 2019.
Samaranayake L., Matsubara V. H. Normal Oral Flora and the Oral Ecosystem. Dental clinics of North America. 2017; 61 (2): 199-215.
Kumar P. S., Mason M. R. Mouthguards: does the indigenous microbiome play a role in maintaining oral health? Frontiers in cellular and infection microbiology. 2015; 5: 35.
Hajishengallis G., Darveau R. P., Curtis M. A. The keystone-pathogen hypothesis. Nature reviews Microbiology. 2012; 10 (10): 717-25.
Mark Welch J. L., Rossetti B. J., Rieken C. W., Dewhirst F. E., Borisy G. G. Biogeography of a human oral microbiome at the micron scale. Proceedings of the National Academy of Sciences of the United States of America. 2016; 113 (6): E791-800.
Costalonga M., Herzberg M. C. The oral microbiome and the immunobiology of periodontal disease and caries. Immunology letters. 2014; 162 (2 Pt A): 22-38.
Huang R., Li M., Gregory R. L. Bacterial interactions in dental biofilm. Virulence. 2011; 2 (5): 435-44.
Takahashi N. Oral Microbiome Metabolism: From "Who Are They?" to "What Are They Doing?". Journal of dental research. 2015; 94 (12): 1628-37.
Patini R., Staderini E., Lajolo C., Lopetuso L., Mohammed H., Rimondini L., et al. Relationship between oral microbiota and periodontal disease: a systematic review. European review for medical and pharmacological sciences. 2018; 22 (18): 5775-88.
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Cristina Barboza-Solís DDS, MSc, PhD
Facultad de Odontología, Universidad de Costa Rica, 2060 San José, Costa Rica.
Luis Alberto Acuña-Amador PhD
Laboratorio de Investigación en Bacteriología Anaerobia, Centro de Investigación en Enfermedades Tropicales, Facultad de Microbiología, Universidad de Costa Rica, 2060 San José, Costa Rica.
How to Cite
The Oral Microbiota: A Literature Review for Updating Professionals in Dentistry. Part I
2020: Online First
Published: Oct 1, 2019
In recent decades, a body of literature examining the relationships between oral health and general health has rapidly developed. However, the biological mechanisms involved in explaining such relationships have not been fully described. Recent evidence has suggested that these relationships could be partially explained by the composition and interaction of the microbiome/microbiota between local and systemic body sites. For instance, it has been suggested that intestinal microbiota could have effects on non-communicable diseases, such as diabetes or cardiovascular diseases. The objective of this study is to explore current evidence of the link between oral and systemic diseases, to discuss whether oral microbiome/microbiota could represent an unexplored biological pathway partially explaining those relationships. A non-systematic review of the literature was carried out using keyword searches in Pubmed from February to May 2019. The ultimate goal was to present recent scientific evidence to update the general knowledge on this topic to professionals in dentistry. This review is divided in two parts for journal publication; however, it is intended to be used as one piece. In this first part, we will summarize the conceptual background of oral microbiome/microbiota, we will describe the main methods used in microbiology to characterize oral organisms, and will present the main composition of bacteria in oral microbiome/microbiota. The second part highlights the main evidence regarding the biological plausibility that links oral microbiome and systemic diseases and we will conclude with some future research recommendations. Taking into account the role of oral microbiota in the development of systemic diseases could change the main paradigm of how oral health is currently conceptualized by dental professionals.