Odovtos - International Journal of Dental Sciences ISSN Impreso: 1659-1046 ISSN electrónico: 2215-3411

OAI: https://revistas.ucr.ac.cr/index.php/Odontos/oai
Immunological and Bacteriological Monitoring of Periodontal Tissue in Pregnancy
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Keywords

Periodontitis; Porphyromonas gingivalis; IgA; Pregnant women.
Periodontitis; Porphyromonas gingivalis; IgA; Embarazo.

How to Cite

Solari, N., Salas, L., Tabares, S., Rosella, C., Usin, M. M., & Sembaj, A. (2023). Immunological and Bacteriological Monitoring of Periodontal Tissue in Pregnancy. Odovtos - International Journal of Dental Sciences, 25(2), 133–143. https://doi.org/10.15517/ijds.2023.54127

Abstract

We determine periodontal pathogens in periodontal pockets from pregnant women with periodontitis and associate it to the C reactive protein (CRP), nitrates, immunoglobulin A and G (Ig A and G), and myeloperoxidase (MPO) levels in saliva to identify some biomarkers as tools to predict the periodontal status from pregnant. The samples were obtained from periodontal pockets and saliva from 100 pregnant women (PW) and 50 non-pregnant women (NPW). Every patient was evaluated by: 1) probing depth (PD) and loss of clinical attachment level (CAL); 2) in saliva; CRP, MPO, Ig A and G) and nitrite concentrations, 3) in periodontal pockets: P.gingivalis, T.forsythia, T.denticola, P.intermedia, A.actinomycetemcomitans. InfoStat/P 2008 software was used with a p-value <0.05. Clinical parameters showed stages I and II of PD in both groups. P.intermedia and A.actinomycetemcomitans were observed only in periodontal pockets from PW. The CAL was higher in pregnant of the 3rd trimester than in the other stages and was associated with low levels of IgA and the presence of P.intermedia and T. forsythia in the same trimester. The levels of IgA in saliva would reflect the immunological situation in pregnant women. This could be used to monitor the immune status of the gingival tissues during pregnancy.

https://doi.org/10.15517/ijds.2023.54127
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References

Papapanou P.N., Sanz M., Buduneli N., Dietrich T., Feres M., Fine DH., et al. Periodontitis: Consensus report of workgroup 2 of the 2017 world Workshop on the classification of Periodontal and Peri-implant Diseases and Conditions. J Periodontol. 2018; 89 Suppl1: S173-S182. doi: 10.1002/JPER.17-0721

Ren H., Du M. Role of Maternal Periodontitis in Preterm Birth. Front Immunol. 2017; 13 (8): 139. doi: 10.3389/fimmu.2017.00139

Carrillo-de-Albornoz Al, Figuero E., Herrera D., Bascones-Martinez A. Gingival changesduring pregnancy: II. Influence of hormonal variations on the subgingival biofilm. J. Clin. Periodontol. 2010; 37 (3): 230-40. doi: 10.1111/j.1600-051X.2009.01514.x

Eick S. Biofilms. Monogr Oral Sci. 2021; 29: 1-11. doi: 10.1159/000510184

Wu M., Chen SW., Jiang SY. Relationship between gingival inflammation and pregnancy. Mediators Inflamm.2015; 623427. doi: 10.1155/2015/623427

Greene J.C., Vermillion J.R. The simplified oral hygiene index. J Am Dent Assoc. 1964; 68: 7-13. doi: 10.14219/jada.archive.1964.0034

Navazesh M. Methods for collecting saliva.Ann N Y Acad Sci.1993; 20; 694: 72-7. doi: 10.1111/j.1749-6632.1993.tb18343.x

Adarmes H., Solís J.P., Müller A.J., Galleguillos M. Nitrite determination as a stable metabolite of nitric oxide in synovial fluid of equine metacarpophalangeal joint. Arch Med Vet 2009; 41: 255-259.

UsinM.M.,Tabares S.M., Parodi R.J., Sembaj A. Periodontal conditions during the pregnancy associated with periodontal pathogens. J Investig Clin Dent. 2013; 4: 54-59.

Ashimoto A., Chen C., Bakker I., Slots J. Polymerase chain reaction detection of 8 putative bacterias periodontal pathogens in subgingival plaque of gingivitis and advanced periodontitis lesions. Oral Microbiol. Inmunol. 1996; 11: 266-273

Barak S., Oettinger-Barak O., Oettinger M., Machtei EE., Peled M., Ohel G. Common oral manifestations during pregnancy: a review. Obstet Gynecol Surv. 2003; 58 (9): 624-8. doi: 10.1097/01.OGX.0000083542.14439.CF

Ye C., Xia Z., Tang J.,Khemwong T., Kapila Y., Kuraji R., et al. Unculturable and culturable periodontal-related bacteria are associated with periodontal inflammation during pregnancy and with preterm low birth weight delivery. Sci Rep. 2020; 25; 10:15807. doi: 10.1038/s41598-020-72807-9

Canakci V., Canakci C.F., Yildirim A., Ingec M., Eltas A., Erturk A. Periodontal disease increases the risk of severe pre-eclampsia among pregnant women. J Clin Periodontol. 2007; 34 (8): 639-45. doi: 10.1111/j.1600-051X.2007.01105.x

Usin M.M., Menso J., Rodríguez V.I., Gonzalez A., Tabares S., Parodi R., Sembaj A. Association between maternal periodontitis and preterm and/or low birth weight infants in normal pregnancies. J Matern Fetal Neonatal Med. 2016; 29 (1): 115-119.

Balan P., Chong Y.S., Umashankar S., Swarup S., MunLoke W., Lopez V., et al. Keystone Species in Pregnancy Gingivitis: A Snapshot of Oral Microbiome During Pregnancy and Postpartum Period. Front Microbiol. 2018; 9: 9: 2360. doi: 10.3389/fmicb.2018.02360

León R., Silva N., Ovalle A., Chaparro A., Ahumada A., Gajardo M., et al. Detection of Porphyromonas gingivalis in the amniotic fluid in pregnant women with a diagnosis of threatened premature labor. J Periodontol. 2007; 78 (7): 1249-1255

Santa Cruz I., Herrera D., Martin C., Herrero A., Sanz M. Association between periodontal status and pre-term and/or low-birth weight in Spain: clinical and microbiological parameters. J Periodont Res. 2013; 48 (4): 443-451

Chopra A., Radhakrishnan R., Sharma M. Porphyromonas gingivalis and adverse pregnancy outcomes: a review on its intricate pathogenic mechanisms. Crit Rev Microbiol. 2020; 46 (2): 213-236

Kim M.A., Lee B.S., Park Y.W., Seo K. Serum markers for prediction of spontaneous preterm delivery in preterm labour: markers for prediction of preterm delivery. Eur J Clin Invest. 2011; 41 (7): 773-780doi: 10.1111/j.1365-2362.2011.02469.x

Moreu G., Tellez L., Gonzalez-Jaranay M. Relationship between maternal periodontal disease and low-birth-weight pre-term infants. J ClinPeriodontol. 2005; 32 (6): 622-627doi: 10.1111/j.1600-051X.2005.00722.x

Adriaens L.M.,Alessandri R., Spörri S., Lang N.P., Persson G.R. Does pregnancy have an impact on the subgingival microbiota? J Periodontol. 2009; 80 (1): 72-81. doi: 10.1902/jop.2009.080012

Lin W., Jiang W., Hu X., Gao L., Ai D., Pan H., et al. Ecological shifts of supragingivalmicrobiota in association with pregnancy. Front Cell Infect Microbiol. 2018; 15; 8: 24doi: 10.3389/fcimb.2018.00024

Paropkari A.D., Leblebicioglu B., Christian LM., Kumar PS.. Smoking, pregnancy and the subgingival microbiome. Sci Rep. 2016; 6: 30388

Mahendra J., Mahendra L., Muthu J., John L., Romanos G.E. Clinical effects of subgingivally delivered spirulina gel in chronic periodontitis cases: a placebo controlled clinical trial. J ClinDiagn Res. 2013; 7 (10): 2330-2333.

Al Moharib H.S., Al Mubarak A., Al Rowis R., Geevarghese A., Preethanath R.S., Anil S. Oral fluid based biomarkers in periodontal disease: part 1. Saliva. J Int Oral Health. 2014; 6 (4): 95-103.

Shojaee M., Fereydooni Golpasha M., Maliji G., Bijani A., Aghajanpour Mir S.M., MousaviKani S.N. C-reactive protein levels in patients with periodontal disease and normal subjects. Int J Mol Cell Med. 2013; 2 (3): 151-155.

Sharma A., Ramesh A., Thomas B. Evaluation of plasma C-reactive protein levels in pregnant women with and without periodontal disease: A comparative study. J Indian Soc Periodontol. 2009; 13:145-149.

Madianos P.N.,Bobetsis G.A., Kinane D.F. Is periodontitis associated with an increased risk of coronary heart disease and preterm and/or low birth weight births? J Clin Periodontol. 2002;29 Suppl 3: 22-36; discussion 37-8.

Isola G., Polizzi A., Patini R., Ferlito S., Alibrandi A., Palazzo G. Association among serum and salivary A. actinomycetemcomitans specific immunoglobulin antibodies and periodontitis. BMC Oral Health. 2020; 15 (1); 20: 283.

Pink C., Kocher T., Meisel P., Dörr M., Markus M.R., Jablonowski L., et al. Longitudinal effects of systemic inflammation markers on periodontitis. J Clin Periodontol. 2015; 42 (11): 988-997.

Taba M. Jr., Kinney J., Kim A.S., Giannobile W.V. Diagnostic Biomarkers for oral and periodontal diseases Dent Clin North Am. 2005; 49: 551-71, vi.].

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