Palabras clave
Colutorio; Enjuagar; Cetilpiridinio; Aerosol; Antisépticos; Aire contaminado.
Cómo citar
Resumen
El presente trabajo de investigación tiene como objetivo determinar la eficacia antimicrobiana de los colutorios a base de cloruro de Cetilpiridinio (CPC), previo a tratamientos dentales que generen aerosol. Se realizó una búsqueda bibliográfica hasta agosto del 2021 en cinco bases de datos: MEDLINE (vía PubMed), SCOPUS, SCIELO, Cochrane Central Register of Controlled Trials (CENTRAL) y Google Scholar. Se incluyeron ensayos clínicos aleatorizados (ECAs), basándose en la pregunta PICOS, que compare la eficacia del colutorio a base de cloruro de Cetilpiridinio (CPC) con otro colutorio, placebo o agua, previo a un tratamiento dental que genere aerosol, en los idiomas español, inglés o portugués y sin límite de tiempo. El riesgo de los estudios incluidos se evaluó con la herramienta RoB 2.0. Número de registro PROSPERO N° CRD42021275982. Se obtuvo un total de 120 artículos en la búsqueda preliminar, descartando aquellos que no cumplían con los criterios de selección, quedando sólo 3articulos. Estos artículos informaron que el uso de CPC es efectivo para la reducción de bacterias durante el procedimiento de profilaxis con ultrasonido. El uso de los enjuagues bucales a base de CPC previo al tratamiento dental de profilaxis con ultrasonido sólo tiene eficacia antibacteriana.
Citas
Watanabe E., Nascimento A.P., Guerreiro-Tanomaru J.M., Razaboni A.M., de Andrade D., Tanomaru-Filho M. Antiseptic mouthwashes: in vitro antibacterial activity. Acta Odontol Latinoam. 2015; 28 (2): 180-4. doi: 10.1590/S1852-48342015000200014
Rösing C.K., Cavagni J., Gaio E.J., Muniz F.W.M.G., Ranzan N., Oballe H.J.R., et al. Efficacy of two mouthwashes with cetylpyridinium chloride: a controlled randomized clinical trial. Braz Oral Res. 2017 Jul 3; 31: e47. doi: 10.1590/1807-3107BOR-2017.vol31.0047
So Yeon L., Si Young L. Susceptibility of Oral Streptococci to Chlorhexidine and Cetylpyridinium Chloride. Biocontrol Sci. 2019; 24 (1):13-21. doi: 10.4265/bio.24.13
Verma S.K., Dev Kumar B., Chaurasia A., Dubey D. Effectiveness of mouthwash against viruses: 2020 perspective. A systematic review. Minerva Dent Oral Sci. 2021 Oct; 70 (5): 206-213. doi: 10.23736/S2724-6329.21.04418-6
Akbulut Y. The effects of different antiseptic mouthwash on microbiota around orthodontic mini-screw. Niger J Clin Pract. 2020 Nov; 23 (11): 1507-1513. doi: 10.4103/njcp.njcp_121_20
Müller H.D., Eick S., Moritz A., Lussi A., Gruber R. Cytotoxicity and Antimicrobial Activity of Oral Rinses In Vitro. Biomed Res Int. 2017; 2017: 4019723. doi: 10.1155/2017/4019723
American Dental Association. Oral health topics: mouthwash (mouthrinse); 2019. Available from https://www.ada.org/en/member-center/oral-health-topics/mouthrinse
Brooks J.K., Bashirelahi N., Hsia R.C., Reynolds M.A. Charcoal-based mouthwashes: a literature review. Br Dent J. 2020 Feb; 228 (4): 290-294. doi: 10.1038/s41415-020-1265-8
Takenaka S., Ohsumi T., Noiri Y. Evidence-based strategy for dental biofilms: Current evidence of mouthwashes on dental biofilm and gingivitis. Jpn Dent Sci Rev. 2019 Nov; 55 (1): 33-40. doi: 10.1016/j.jdsr.2018.07.001
Marui V.C., Souto M.L.S., Rovai E.S., Romito G.A., Chambrone L., Pannuti C.M. Efficacy of preprocedural mouthrinses in the reduction of microorganisms in aerosol: A systematic review. J Am Dent Assoc. 2019 Dec; 150 (12): 1015-1026.e1. doi: 10.1016/j.adaj.2019.06.024
Mao X., Auer D.L., Buchalla W., Hiller K.A., Maisch T., Hellwig E., et al. Cetylpyridinium Chloride: Mechanism of Action, Antimicrobial Efficacy in Biofilms, and Potential Risks of Resistance. Antimicrob Agents Chemother. 2020 Jul 22; 64 (8): e00576-20. doi: 10.1128/AAC.00576-20
Pitten F.A., Kramer A. Efficacy of cetylpyridinium chloride used as oropharyngeal antiseptic. Arzneimittelforschung. 2001; 51 (7): 588-95. doi: 10.1055/s-0031-1300084
Van der Weijden F.A., Van der Sluijs E., Ciancio S.G., Slot D.E. Can Chemical Mouthwash Agents Achieve Plaque/Gingivitis Control? Dent Clin North Am. 2015 Oct; 59 (4): 799-829. doi: 10.1016/j.cden.2015.06.002
Baker N., Williams A.J., Tropsha A., Ekins S. Repurposing Quaternary Ammonium Compounds as Potential Treatments for COVID-19. Pharm Res. 2020 May 25; 37 (6): 104. doi: 10.1007/s11095-020-02842-8
Moran J.M. Home-use oral hygiene products: mouthrinses. Periodontol 2000. 2008; 48: 42-53. doi: 10.1111/j.1600-0757.2008.00260.x
Herrera D., Santos S., Ferrús J., Barbieri G., Trombelli L., Sanz M. Efficacy of a 0.15% benzydamine hydrochloride and 0.05% cetylpyridinium chloride mouth rinse on 4-day de novo plaque formation. J Clin Periodontol. 2005 Jun; 32 (6): 595-603. doi: 10.1111/j.1600-051X.2005.00718.x
Miranda S.L.F., Damaceno J.T., Faveri M., Figueiredo L.C., Soares G.M.S., Feres M., et al. In Vitro Antimicrobial Effect of Cetylpyridinium Chloride on Complex Multispecies Subgingival Biofilm. Braz Dent J. 2020 Mar-Apr; 31 (2): 103-108. doi: 10.1590/0103-6440202002630
Gunsolley J.C. Clinical efficacy of antimicrobial mouthrinses. J Dent. 2010 Jun; 38 Suppl 1: S6-10. doi: 10.1016/S0300-5712(10)70004-X
Ouhayoun J.P. Penetrating the plaque biofilm: impact of essential oil mouthwash. J Clin Periodontol. 2003; 30 Suppl 5: 10-2. doi: 10.1034/j.1600-051x.30.s5.4.x
García V., Rioboo M., Serrano J., O'Connor A., Herrera D., Sanz M. Plaque inhibitory effect of a 0.05% cetyl-pyridinium chloride mouth-rinse in a 4-day non-brushing model. Int J Dent Hyg. 2011 Nov; 9 (4): 266-73. doi: 10.1111/j.1601-5037.2010.00490.x
Haps S., Slot D.E., Berchier C.E., Van der Weijden G.A. The effect of cetylpyridinium chloride-containing mouth rinses as adjuncts to toothbrushing on plaque and parameters of gingival inflammation: a systematic review. Int J Dent Hyg. 2008 Nov; 6 (4): 290-303. doi: 10.1111/j.1601-5037.2008.00344.x
Van Leeuwen M.P., Rosema N.A., Versteeg P.A., Slot D.E., Van Winkelhoff A.J., Van der Weijden G.A. Long-term efficacy of a 0.07% cetylpyridinium chloride mouth rinse in relation to plaque and gingivitis: a 6-month randomized, vehicle-controlled clinical trial. Int J Dent Hyg. 2015 May; 13 (2): 93-103. doi: 10.1111/idh.12082
Mukherjee P.K., Esper F., Buchheit K., Arters K., Adkins I., Ghannoum M.A., et al. Randomized, double-blind, placebo-controlled clinical trial to assess the safety and effectiveness of a novel dual-action oral topical formulation against upper respiratory infections. BMC Infect Dis. 2017 Jan 14; 17 (1): 74. doi: 10.1186/s12879-016-2177-8
Carrouel F., Gonçalves L.S., Conte M.P., Campus G., Fisher J., Fraticelli L., et al. Antiviral Activity of Reagents in Mouth Rinses against SARS-CoV-2. J Dent Res. 2021 Feb; 100 (2): 124-132. doi: 10.1177/0022034520967933
Seo H.W., Seo J.P., Kim Y.J., Jung G. WITHDRAWN: Cetylpyridinium chloride as a novel inhibitor of hepatitis B viral capsid assembly. Biochem Biophys Res Commun. 2018 Jan 17: S0006-291X (18) 30103-7. doi: 10.1016/j.bbrc.2018.01.088
Alvarez D.M., Duarte L.F., Corrales N., Smith P.C., González P.A. Cetylpyridinium chloride blocks herpes simplex virus replication in gingival fibroblasts. Antiviral Res. 2020 Jul;179:104818. doi: 10.1016/j.antiviral.2020.104818
Harrel S.K., Molinari J. Aerosols and splatter in dentistry: a brief review of the literature and infection control implications. J Am Dent Assoc. 2004 Apr; 135 (4): 429-37. doi: 10.14219/jada.archive.2004.0207
Innes N., Johnson I.G., Al-Yaseen W., Harris R., Jones R., Kc S., McGregor S., et al.A systematic review of droplet and aerosol generation in dentistry. J Dent. 2021 Feb;105:103556. doi: 10.1016/j.jdent.2020.103556
Ge Z.Y., Yang L.M., Xia J.J., Fu X.H., Zhang Y.Z. Possible aerosol transmission of COVID-19 and special precautions in dentistry. J Zhejiang Univ Sci B. 2020 May; 21 (5): 361-368. doi: 10.1631/jzus.B2010010
Zemouri C., Volgenant C.M.C., Buijs M.J., Crielaard W., Rosema N.A.M., Brandt B.W., et al. Dental aerosols: microbial composition and spatial distribution. J Oral Microbiol. 2020 May 13; 12 (1): 1762040. doi: 10.1080/20002297.2020.1762040
Hubar J.S., Pelon W. Low-cost screening for microbial contaminants in aerosols generated in a dental office. Gen Dent. 2005 Jul-Aug; 53 (4): 270-2. PMID: 16158795.
Joshi A.A., Padhye A.M., Gupta H.S. Efficacy of Two Pre-Procedural Rinses at Two Different Temperatures in Reducing Aerosol Contamination Produced During Ultrasonic Scaling in a Dental Set-up - A Microbiological Study. J Int Acad Periodontol. 2017 Oct 1; 19 (4): 138-144. PMID: 31473729.
Matys J., Grzech-Leśniak K. Dental Aerosol as a Hazard Risk for Dental Workers. Materials (Basel). 2020 Nov 12; 13 (22): 5109. doi: 10.3390/ma13225109
Herrera D., Escudero N., Pérez L., Otheo M., Cañete-Sánchez E., Pérez T., et al. Clinical and microbiological effects of the use of a cetylpyridinium chloride dentifrice and mouth rinse in orthodontic patients: a 3-month randomized clinical trial. Eur J Orthod. 2018 Sep 28; 40 (5): 465-474. doi: 10.1093/ejo/cjx096
Haraszthy V.I., Sreenivasan P.K. Microbiological and clinical effects of an oral hygiene regimen. Contemp Clin Trials Commun. 2017 Aug 18; 8: 85-89. doi: 10.1016/j.conctc.2017.08.010
Feres M., Figueiredo L.C., Faveri M., Stewart B., de Vizio W. The effectiveness of a preprocedural mouthrinse containing cetylpyridinium chloride in reducing bacteria in the dental office. J Am Dent Assoc. 2010 Apr; 141 (4): 415-22. doi: 10.14219/jada.archive.2010.0193
Retamal-Valdes B., Soares G.M., Stewart B., Figueiredo L.C., Faveri M., Miller S., et al. Effectiveness of a pre-procedural mouthwash in reducing bacteria in dental aerosols: randomized clinical trial. Braz Oral Res. 2017 Mar 30; 31: e21. doi: 10.1590/1807-3107BOR-2017.vol31.0021
Seneviratne C.J., Balan P., Ko K.K.K., Udawatte N.S., Lai D., Ng D.H.L., et al. Efficacy of commercial mouth-rinses on SARS-CoV-2 viral load in saliva: randomized control trial in Singapore. Infection. 2021 Apr; 49 (2): 305-311. doi: 10.1007/s15010-020-01563-9
Mateos-Moreno M.V., Mira A., Ausina-Márquez V., Ferrer M.D. Oral antiseptics against coronavirus: in-vitro and clinical evidence. J Hosp Infect. 2021 Jul; 113: 30-43. doi: 10.1016/j.jhin.2021.04.004
Moosavi M.S., Aminishakib P., Ansari M. Antiviral mouthwashes: possible benefit for COVID-19 with evidence-based approach. J Oral Microbiol. 2020 Jul 17; 12 (1): 1794363. doi: 10.1080/20002297.2020.1794363
Cavalcante-Leão B.L., de Araujo C.M., Basso I.B., Schroder A.G., Guariza-Filho O., Ravazzi G.C., et al. Is there scientific evidence of the mouthwashes effectiveness in reducing viral load in Covid-19? A systematic review. J Clin Exp Dent. 2021 Feb 1; 13 (2): e179-e189. doi: 10.4317/jced.57406
Amato A., Caggiano M., Amato M., Moccia G., Capunzo M., De Caro F. Infection Control in Dental Practice During the COVID-19 Pandemic. Int J Environ Res Public Health. 2020 Jul 2; 17 (13): 4769. doi: 10.3390/ijerph17134769
Popkin D.L., Zilka S., Dimaano M., Fujioka H., Rackley C., Salata R., et al. Cetylpyridinium Chloride (CPC) Exhibits Potent, Rapid Activity Against Influenza Viruses in vitro and in vivo. Pathog Immun. 2017; 2 (2): 252-269. doi: 10.20411/pai.v2i2.200
Vergara-Buenaventura A., Castro-Ruiz C. Use of mouthwashes against COVID-19 in dentistry. Br J Oral Maxillofac Surg. 2020 Oct; 58 (8): 924-927. doi: 10.1016/j.bjoms.2020.08.016
Bentley C.D., Burkhart N.W., Crawford J.J. Evaluating spatter and aerosol contamination during dental procedures. J Am Dent Assoc. 1994 May; 125 (5): 579-84. doi: 10.14219/jada.archive.1994.0093
Grenier D. Quantitative analysis of bacterial aerosols in two different dental clinic environments. Appl Environ Microbiol. 1995 Aug; 61 (8): 3165-8. doi: 10.1128/aem.61.8.3165-3168.1995
Rivera-Hidalgo F., Barnes J.B., Harrel S.K. Aerosol and splatter production by focused spray and standard ultrasonic inserts. J Periodontol. 1999 May; 70 (5): 473-7. doi: 10.1902/jop.1999.70.5.473
Reddy S., Prasad M.G., Kaul S., Satish K., Kakarala S., Bhowmik N. Efficacy of 0.2% tempered chlorhexidine as a pre-procedural mouth rinse: A clinical study. J Indian Soc Periodontol. 2012 Apr; 16 (2): 213-7. doi: 10.4103/0972-124X.99264. PMID: 23055587; PMCID: PMC3459501
Calle R., Sánchez D.B.B.Y.A.G. Actualización de las infecciones respiratorias en Urgencias [Update on respiratory infections in the emergency department]. Medicine (Madr). 2019 Oct; 12 (88): 5170-5179. Spanish. doi: 10.1016/j.med.2019.10.013. Epub 2019 Nov 7. PMID: 32287912; PMCID: PMC7143591.
Han Y.W. Fusobacterium nucleatum: a commensal-turned pathogen. Curr Opin Microbiol. 2015 Feb; 23: 141-7. doi: 10.1016/j.mib.2014.11.013. Epub 2015 Jan 8. PMID: 25576662; PMCID: PMC4323942
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