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Resumo
Throughout its evolutionary course, stress has remained as an adaptive response to stimuli that may jeopardize the integrity of an organism. Within this perspective, we can classify the stressors as psychological,
physical or harmful to cardiovascular stability. However, when intense stressful events occur, there is a possibility of developing PTSD. This disorder makes use of the hypothalamic-pituitary-adrenal axis, which is commonly activated during stress and is kept activated even when the stressful stimulus has ended months ago. The consequences of this condition are observed at the neuroendocrine, neurochemical and anatomical level. This review aims to give a brief report of the neurobiology of stress, PTSD, and its implications in various structures,
such as the amygdala, hippocampus and prefrontal cortex.
Referências
Arnsten, A.F. (2000). Through the looking glass: differential noradenergic modulation of prefrontal cortical function. Neural Plast, 7, 133-46.
Arnsten, A.F. (2009). Stress signalling pathways that impair prefrontal cortex structure and function. Nat Rev Neurosci, 10, 410-22.
Aston-Jones, G., Rajkowski, J., & Cohen, J. (1999). Role of locus coeruleus in attention and behavioral flexibility. Biol Psychiatry, 46, 1309-20.
Bailey, C.R., Cordell, E., Sobin, S.M., & Neumeister, A. (2013). Recent progress in understanding the pathophysiology of post-traumatic stress disorder: implications for targeted pharmacological treatment. CNS Drugs, 27, 221-32.
Birnbaum, S., Gobeske, K.T., Auerbach, J., Taylor, J.R. & Arnsten, A.F. (1999). A role for norepinephrine in stress-induced cognitive deficits: alpha-1-adrenoceptor mediation in the prefrontal cortex. Biol Psychiatry, 46, 1266-74.
Bremner, J.D. (2005). Effects of traumatic stress on brain structure and function: relevance to early responses to trauma. J Trauma Dissociation, 6, 51-68.
Bremner, J.D. (2006). Traumatic stress: effects on the brain. Dialogues Clin Neurosci, 8, 445-61.
Carrasco, G. A., & Van de Kar, L. D. (2003). Neuroendocrine pharmacology of stress. Eur J Pharmacol, 463(1-3), 235-272.
Gurvits, T. V., Shenton, M. E., Hokama, H., Ohta, H., Lasko, N. B., Gilbertson, M. W., . . . Pitman, R. K. (1996). Magnetic resonance imaging study of hippocampal volume in chronic, combat-related posttraumatic stress disorder. Biol Psychiatry, 40(11), 1091-1099 doi: 10.1016/S0006-3223(96)00229-6
Holmes, A., & Wellman, C.L. (2009). Stress-induced prefrontal reorganization and executive dysfunction in rodents. Neurosci Biobehav Rev, 33, 773-83.
Hubbard, D.T., Nakashima, B.R., Lee, I. & Takahashi, L.K. (2007). Activation of basolateral amygdala corticotropin-releasing factor 1 receptors modulates the consolidation of contextual fear. Neuroscience, 150, 818-28.
Humphreys, K.L., Sauder, C.L., Martin, E.K. & Marx, B.P. (2009). Tonic immobility in childhood sexual abuse survivors and its relationship to posttraumatic stress symptomatology. J Interpers Violence, 25, 358-73.
Keltner, N.L. & Dowben, J.S. (2007). Psychobiological substrates of posttraumatic stress disorder--part I. Perspect Psychiatr Care, 43, 97-101.
Lanius, R.A., Vermetten, E., Loewenstein, R.J., Brand, B., Schmahl, C., Bremner, J.D. & Spiegel, D. (2010). Emotion modulation in PTSD: Clinical and neurobiological evidence for a dissociative subtype. Am J Psychiatry, 167, 640-7.
Li, B.M. & Mei, Z.T. (1994). Delayed-response deficit induced by local injection of the alpha 2-adrenergic antagonist yohimbine into the dorsolateral prefrontal cortex in young adult monkeys. Behav Neural Biol, 62, 134-9.
Li, B.M., Mao, Z.M., Wang, M. & Mei, Z.T. (1999). Alpha-2 adrenergic modulation of prefrontal cortical neuronal activity related to spatial working memory in monkeys. Neuropsychopharmacology, 21, 601-10.
Michelsen, K.A., van den Hove, D.L., Schmitz, C., Segers, O., Prickaerts, J. & Steinbusch, H.W. (2007). Prenatal stress and subsequent exposure to chronic mild stress influence dendritic spine density and morphology in the rat medial prefrontal cortex. BMC Neurosci, 8, 107.
Mills, K. (2013). Treatment of comorbid substance dependence and posttraumatic stress disorder. JAMA, 310, 482-3.
Peskind, E.R., Bonner, L.T., Hoff, D.J. & Raskind, M.A. (2003). Prazosin reduces trauma-related nightmares in older men with chronic posttraumatic stress disorder. J Geriatr Psychiatry Neurol, 16, 165-71.
Petrov, T., Krukoff T.L., & Jhamandas J.H. (1994). Chemically defined collateral projections from the pons to the central nucleus of the amygdala and hypothalamic paraventricular nucleus in the rat. Cell
Tissue Res. 277(2), 289-95.
Pfaff, D. W., Silva, M. T., & Weiss , J. M. (1971). Telemetered recording of hormone effects on hippocampal neurons. Science, 172(3981), 394-5.
Protopopescu, X., Pan, H., Tuescher, O., Cloitre, M., Goldstein, M., Engelien, W., Epstein, J., Yang, Y., Gorman, J., LeDoux, J., Silbersweig, D., & Stern, E. (2005). Differential time courses and specificity of
amygdala activity in posttraumatic stress disorder subjects and normal control subjects. Biol Psychiatry, 57(5), 464-73.
Radley, J.J., Rocher, A.B., Miller, M., Janssen, W.G., Liston, C., Hof, P.R., McEwen, B.S. & Morrison, J.H. (2006). Repeated stress induces dendritic spine loss in the rat medial prefrontal cortex. Cereb Cortex, 16, 313-20.
Ramos, B. P., Colgan, L., Nou, E., Ovadia, S., Wilson, S. R., & Arnsten, A. F. (2005). The beta-1 adrenergic antagonist, betaxolol, improves working memory performance in rats and monkeys. Biol Psychiatry, 58(11), 894-900. doi: 10.1016/j.biopsych.2005.05.022
Raskind, M.A., Thompson, C., Petrie, E.C., Dobie, D.J., Rein, R.J., Hoff, D.J., McFall, M.E. & Peskind, E.R. (2002). Prazosin reduces nightmares in combat veterans with posttraumatic stress disorder. J Clin Psychiatry, 63, 565-8.
Shestatzky, M., Greenberg, D., & Lerer, B. (1998). A controlled trial of phenelzine in posttraumatic stress disorder. Psychiatry Res. 24(2), 149-55.
Shin L.M., Orr SP, Carson M.A., Rauch S.L., Macklin M.L., Lasko N.B., Peters P.M., Metzger L., Dougherty D.D., Cannistraro P.A., Alpert N.M., Fischman A.J., & Pitman R.K. (2004). Regional cerebral blood flow in the amygdala and medial prefrontal cortex during traumatic imagery in male and female Vietnam veterans with PTSD. Arch Gen Psychiatry, 61(2), 168-76.
Shin, L.M., Wright, C.I., Cannistraro, P.A., Wedig, M.M., McMullin, K., Martis, ... Rauch, S.L. (2005). A functional magnetic resonance imaging study of amygdala and medial prefrontal cortex responses to overtly presented fearful faces in posttraumatic stress disorder. Arch Gen Psychiatry, 62(3), 273-81.
Squire, L.R., & Zola-Morgan, S. (1991). The medial temporal lobe memory system. Science, 253(5026), 1380-6.
Stein, M. B., Koverola, C., Hanna, C., Torchia, M. G., & McClarty, B. (1997). Hippocampal volume in women victimized by childhood sexual abuse. Psychol Med, 27(4), 951-959.
Uno H, Eisele S, Sakai A, Shelton S, Baker E, DeJesus O, & Holden J. (2004). Neurotoxicity of glucocorticoids in the primate brain. Horm Behav, 28(4), 336-48.
Van de Kar, L. D., & Blair, M. L. (1999). Forebrain pathways mediating stress-induced hormone secretion. Front Neuroendocrinol, 20(1), 1-48. doi:10.1006/frne.1998.0172
Vermetten, E., Schmahl, C, Southwick, S.M., & Bremner, J.D. (2007). Positron tomographic emission study of olfactory induced emotional recall in veterans with and without combat-related posttraumatic stress disorder. Psychopharmacol Bull, 40(1), 8-30.
Wang, M., Ramos, B.P., Paspalas, C.D., Shu, Y., Simen, A., Duque, A. … Arnsten, A.F. (2007). Alpha2A-adrenoceptors strengthen working memory networks by inhibiting cAMP-HCN channel signaling in prefrontal cortex. Cell, 129, 397-410.
Womble, A.L. (2013). Effects of ketamine on major depressive disorder in a patient with posttraumatic stress disorder. AANA J, 81, 118-9.
Zhang, J., Tan, Q., Yin, H., Zhang, X., Huan, Y., Tang, L. & Li, L. (2011). Decreased gray matter volume in the left hippocampus and bilateral calcarine cortex in coal mine flood disaster survivors with recent onset PTSD. Psychiatry Res, 192(2), 84-90. doi:10.1016/j.pscychresns.2010.09.001