Bartolomeo, M.P., and F. Maisano. 2006. Validation of a reversed-phase HPLC method for quantitative amino acid analysis. J. Biomol. Tech. 17:131-137.
Bremmer, D.R., T.R. Overton, and J.H. Clark. 1997. Production and composition of milk from Jersey cows administered bovine somatotropin and fed ruminally protected amino acids. J. Dairy Sci. 80:1374-80.
Chen, Z.H., G.A. Broderick, N.D. Luchini, B.K. Sloan, and E. Devillard. 2011. Effect of feeding different sources of rumen protected methionine on milk production and N-utilization in lactating dairy cows. J. Dairy Sci. 94:1978-88.
Elizondo, J. 2006. El nitrógeno en los sistemas ganaderos de leche. Agron. Mesoam. 17:69-77.
Giallongo, F., M. Harper, J. Lopes, H. Lapierre, R. Patton, C. Parys, I. Shinzato, and N. Hristov. 2016. Effects of rumenprotected methionine, lysine, and histidine on lactation performance of dairy cows. J. Dairy Sci. 99:4437-4452.
Hargraves, J.N.G., and J.D. Kerr. 1978. Botanal: a comprehensive sampling and computing procedure for estimating pasture yield and composition. II. Computational package. Commonwealth Scientific and Industrial Research Organization (CSIRO). Brisbane, AUS.
Hansen, W.P., D.E. Otterby, J.G. Linn, and J.D. Donker. 1991. Influence of forage type, ratio of forage to concentrate, and methionine hydroxy analog on performance of dairy cows. J. Dairy Sci. 74:1361-1369.
Hristov, A., and F. Giallongo. 2014. Feeding protein to dairy cows- What should be our target? In: M.L. Eastridge, editor, Proc. Tri-State Dairy Nutr. Conf., Fort Wayne. Ohio State University, Columbus, IN, USA. p. 75-84.
Jiménez, J., y J. Elizondo. 2014. Balance de nitrógeno en fincas para la producción de leche en Costa Rica. Agron. Mesoam. 25:151-160.
Jonker, J.S., R.A. Kohn, and R.A. Erdman. 1998. Using milk urea nitrogen to predict nitrogen excretion and utilization efficiency in lactating dairy cows. J. Dairy Sci. 81:2681-2692.
Johnson-Vanwieringen, L.M., J.H. Harrison, D. Davidson, M.L. Swift, M.A. Von-Keyserlingk, M. Vázquez-Anón, and W. Chalupa. 2007. Effects of rumen-undegradable protein sources and supplemental 2-hydroxy-4-(methylthio)-butanoic acid and lysine-HCl on lactation performance in dairy cows. J. Dairy Sci. 90:5176-5188.
Klangnok, P., P. Lounglawann, and W. Suksombat. 2011. Effects of met hydroxy analog (MHA®) supplementation of dairy cow’s diets on milk yield and milk composition. Suranaree J. Sci. Technol. 18:99-108.
Lapierre, H., M. Vázquez-Anón, D. Parker, P. Dubreuil, G. Holtrop, and G.E. Lobley. 2011. Metabolism of 2-hydroxy-4- (methylthio) butanoate (HMTBA) in lactating dairy cows. J. Dairy Sci. 94:1526-35.
Leonardi, C., M. Stevenson, and L.E. Armentano. 2003. Effect of two levels of crude protein and methionine supplementation on performance of dairy cows. J. Dairy Sci. 86:4033-4042.
NRC (National Research Council). 2001. Nutrient requirements of dairy cattle. 7th ed. National Academy Press, WA, USA.
Patterson, J., and L. Kung. 1988. Metabolism of DL-methionine and methionine analogs by rumen microorganisms. J. Dairy Sci. 71:3292-3301.
Piepenbrink, M.S., T.R. Overton, and J.H. Clark. 1996. Response of cows fed a low crude protein diet to ruminally protected methionine and lysine. J. Dairy Sci. 79:1638-1646.
Phipps, R.H., C.K. Reynolds, D.I. Givens, A.K. Jones, P. Geraert, E. Devillard, and R. Bennett. 2008. Short communication: effects of 2-hydroxy-4-(methylthio) butanoic acid isopropyl ester on milk production and composition of lactating Holstein dairy cows. J. Dairy Sci. 91:4002-4005.
Polan, C.E., K.A. Cummins, C.J. Sniffen, T.V. Muscato, J.L. Vicini, B.A. Crooker, and S.B. Peirce-Sandner. 1991. Responses of dairy cows to supplemental rumen-protected forms of methionine and lysine. J. Dairy Sci. 74:2997-3013.
Rulquin, H., and L. Delaby. 1997. Effects of the energy balance of dairy cows on lactational responses to rumen-protected methionine. J. Dairy Sci. 80:2513-2522.
Rulquin, H., B. Graulet, L. Delaby, and J.C. Robert. 2006. Effect of different forms of methionine on lactational performance of dairy cows. J. Dairy Sci. 89:4387-4394.
SAS. 2004. SAS/STAT 9.1 User’s guide. Version 9.1 ed. SAS Institute Inc., Cary, NC, USA.
Schwab, C.G., C.K. Bozak, N.L. Whitehouse, and M.M. Mesbah. 1992. Amino acid limitation and flow to duodenum at four stages of lactation. 1. Sequence of lysine and methionine limitation. J. Dairy Sci. 75:3486-3502.
Schwab, C.G. 1995. Rumen protected amino acids – their role in nutrition of high producing ruminants. In: M. Ivan, editor, Animal science research and development: moving toward a new century. Can. Soc. Anim. Sci., Ottawa, ON, CAN. p. 161-175
Sharma, B.K., and R.A. Erdman.1988. Abomasal infusion of choline and methionine with or without 2-amino-2-methyl-1-propanol for lactating dairy cows. J. Dairy Sci. 71:2406-2411.
St-Pierre, N.R., and J.T. Sylvester. 2005. Effects of 2-hydroxy-4-(methylthio) butanoic acid (HMB) and its isopropyl ester on milk production and composition by Holstein cows. J. Dairy Sci. 88:2487-2497.
Van-Soest, P.J., J.B. Robertson, and B.A. Lewis. 1991. Methods for Dairy fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition. J. Dairy Sci. 74:3583-3597.
Wang, C., H.Y. Liu, Y.M. Wang, Z.W. Yang, J.X. Liu, Y.M. Wu, and H.W. Ye. 2010. Effects of dietary supplementation of methionine and lysine on milk production and nitrogen utilization in dairy cows. J. Dairy Sci. 93:3661-3670.
Whelan, S.J., F.J. Mulligan, B. Flynn, C. McCarney, and K.M. Pierce. 2011. Effect of forage source and a supplementary methionine hydroxy analog on nitrogen balance in lactating dairy cows offered a low crude protein diet. J. Dairy Sci. 94:5080-5089.
Wittcoff, H., B. Reuben, and J.S. Plotkin. 2013. Industrial organic chemicals. 3th ed. Wiley, NJ, USA.
Xu, S., J.H. Harrison, W. Chalupa, C. Sniffen, W. Julien, H. Sato, and T. Fujieda. 1998. The effect of ruminal bypass lysine and methionine on milk yield and composition of lactating cows. J. Dairy Sci. 81:1062-1077.
Zanton, G.I., G.R. Bowman, M. Vázquez-Anón, and L.M. Rode. 2014. Meta-analysis of the lactation performance in dairy cows receiving supplemental dietary methionine sources or postruminal infusion of methionine. J. Dairy Sci. 97:1-17.
- Abstract viewed - 1302 times
- PDF (Español (España)) downloaded - 478 times
- HTML (Español (España)) downloaded - 471 times
- EPUB (Español (España)) downloaded - 184 times
Omar Vargas Villalobos
Cooperativa de Productores de Leche, Dos Pinos R.L.
Oscar Cambronero Castro
Faryvet S.A., Unidad de Investigación.
Jorge Alberto Elizondo Salazar
Universidad de Costa Rica
How to Cite
Supplementation of methionine hydroxy analog: effect on dairy cow performance
Agronomía Mesoamericana: Vol. 28, Issue 3 (September-December)
Published: Sep 1, 2017
Supplementing dairy cows with low in protein diets with specific amino acids is a promising strategy to counteract the potential negative effect of metabolizable protein deficiency on productivity. The objective of this study was to quantify the productive performance of lactating dairy cows and their milk quality when they are offered two diets with different crude protein (CP) concentration and when they are supplemented with methionine hydroxy analog (HMTBA). This study was carried out in a commercial dairy farm located in Alfaro Ruiz-Alajuela, Costa Rica, during the first semester of 2014. Twenty multiparous Holstein cows under a grazing system were grouped according to days in lactation and calving number. Two diets with different concentrations of CP (high 16.6% and 15.8% standard), with or without inclusion of HMTBA (25 g/TM) were studied in a 2x2 factorial arrangement. No significant effects (P>0.05) on milk production, 4% fat corrected milk, milk fat, milk protein, lactose, total solids or milk urea nitrogen (MUN) were found when including HMTBA. Feeding cows with high CP concentration significantly increased (P<0.05) MUN concentration from 18.33 to 20.70 mg/dl. Supplementing HMTBA to grazing cows did not have a significant response (P>0.05) regarding the different variables, and no financial return was found due to the fact that neither total milk production nor total solids were increased.