Schizophrenia is one of the most severe mental disorders that affect 1% of the population worldwide. It is clear that both genetic and envi- ronmental factors participate in its etiology. Nonetheless, the effort to identify susceptibility genes has been dif- ficult and there are no unequivocal findings until now. Notwithstanding this, during the last couple of years, a group of candidate genes has been identified because of their possible role in the physiopathology or by associ- ation and linkage studies. In this article, the role of these genes is summarized as well as the results of the stud- ies conducted in Costa Rica by our group.
Keywords: schizophrenia, susceptibility genes, candidate genes, Costa Rica