Revista de Biología Tropical ISSN Impreso: 0034-7744 ISSN electrónico: 2215-2075

OAI: https://revistas.ucr.ac.cr/index.php/rbt/oai
In vitro multiplication of <i>Toxoplasma gondii</i> and <i>Trypanosoma cruzi</i> in mouse, rat, and hamster astrocytes
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Keywords

Toxoplasma gondii
Trypanosoma cruzi
cell culture
astrocyte
rat
mouse
hamster

How to Cite

Troyo, A., & Chinchilla, M. (2003). In vitro multiplication of <i>Toxoplasma gondii</i> and <i>Trypanosoma cruzi</i> in mouse, rat, and hamster astrocytes. Revista De Biología Tropical, 51(3-4), 639–646. Retrieved from https://revistas.ucr.ac.cr/index.php/rbt/article/view/15833

Abstract

The infection and multiplication of Toxoplasma gondii and Trypanosoma cruzi were compared in primary cultures of white rat, mouse and hamster astrocytes. These cells were cultured on cover slides and infected with T. gondii tachyzoites or T. cruzi blood trypomastigotes. Results show that hamster astrocytes are more susceptible to the multiplication of both parasites than rat and mouse cells. There was no statistical difference between the T. gondii infection in rat and mouse astrocytes (p<0.05), and this suggests an important role of other mechanisms or cells in the white rat natural resistance to this parasite. Because the hamster astrocytes are less resistant to these parasites multiplication and not necessarily to the invasion, any difference observed could be due to an intracellular effect: hamster brain astrocytes favor survival and multiplication of these parasites.
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