Revista Clínica Escuela de Medicina UCR-HSJD ISSN electrónico: 2215-2741

OAI: https://revistas.ucr.ac.cr/index.php/clinica/oai
Progreso médico: encefalitis autoinmune contra el receptor de N-metil-D-aspartato asociada a teratomas
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Keywords

Anti -NMDA receptor encephalitis; ovarian teratoma; autoimmune encephalitis; paraneoplastic neurological syndromes
Encefalitis anti receptor NMDA; teratoma ovárico; encefalitis autoinmune; síndromes neurológicos paraneoplásicos

Abstract

Autoimmune encephalitis against the N-methyl-D-aspartate receptor (NMDA-R) is a newly discovered disease that occurs mainly in young women. It is characterized by the presence of autoantibodies against NMDA receptor, specifically against the GluN1 subunit; which generates psychotic symptoms, movement disorders, autonomic dysfunction and even coma. About 50% of patients present ovarian teratoma when completing the studies. This disease is reversible and treatable, therefore diagnosis and treatment are essential. The first line of treatment includes steroids, intravenous G immunoglobulin or plasmapheresis. The second line consists of rituximab and cyclophosphamide. In addition, in the cases where a tumor is documented, the extirpation of it is considered fundamental.

https://doi.org/10.15517/rc_ucr-hsjd.v9i2.37405
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