Revista de Biología Tropical ISSN Impreso: 0034-7744 ISSN electrónico: 2215-2075

OAI: https://revistas.ucr.ac.cr/index.php/rbt/oai
Enfermedad de. Lafora y efecto fundador en una pequeña localidad neotropical
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Keywords

lafora disease
myoclonic epilepsy
founder effect

How to Cite

Solís, M. V. (2000). Enfermedad de. Lafora y efecto fundador en una pequeña localidad neotropical. Revista De Biología Tropical, 48(2-3), 703–706. https://doi.org/10.15517/rbt.v48i2-3.18879

Abstract

The Lafora disease is an uncommon genetic condition. Four cases (two families) were detected in Zarcero, a small town in Costa Rica (population under 2000). They belonged 10 two separate consanguineous marriages but both families had common ancestors. The. diagnosis ·of Lafora disease was confrrmed by liver. biopsy' in one of the patients. The ages of onset .were 13, 14, 16 and 17 years. Patients died after four, nine, six and fi ve years of severe progressive physical and mental deterioration, respectively. The gene for Lafora disease arrive to Zarcero from one of its founders. There are no other cases reported from Co.sta Rica: this is an exampie of genetic drift, or more specifically; founder effect.
https://doi.org/10.15517/rbt.v48i2-3.18879
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