Abstract
Biochemically and pharmacologically, myotoxins isolated from snake venoms can be placed in four main groups: myolaxic phospholipases A, low molecular weight basic toxins, cardiotoxins, and hemorrhagic myotoxins. The myotoxic phospholipascs A notexin, taipoxin, crotoxin, and Bothrops asper myotoxin induce muscle necrosis by first affecting the integrity of the plasma membrane, thereby inducing a calcium influx that culminates in cell death. The small basic myotoxin crotamine acts on the voltage-sensitive sodium channels of skeletal muscle sarcolemma, inducing a sodium influx which is responsible for depolarization and contraction of skeletal muscle, as well as for vacuolization of sarcoplasmic reticulum. Cardiotoxins are basic membrane-active polypeptides that disorganize the structure of membranes; the myotoxic activity of cardiotoxins results from their ability to disrupt skeletal muscle sarcolemma. Finally, two hemorrhagic toxins (hemorrhagic toxin b and viriditoxin) are myotoxic; apparently, they induce myonecrosis secondarily to ischemia which develops in muscular tissue as a consequence of the hemorrhagic action of these toxins.
References
Bjarnason, J. B., & A. T. Tu. 1978. Hemorrhagic toxins from Western diamondback rattlesnake (Crotalus atrox) venom: Isolation and characterization of five toxins and the role of zinc in hemorrhagic toxin e. Biochemistry, 17: 3395-3404.
Cameron, D., & A. T. Tu. 1977. Characterization of myotoxin a from the venom of prairie rattlesnake (Crotalus viridis viridis). Biochemistry, 16: 2546-2553.
Cameron, D. L., & A. T. Tu. 1978. Chemical and functional homology of myotoxin a from prairie rattlesnake venom and crotamine from South American rattlesnake venom. Biochim. Biophys. Acta, 532: 147-154.
Cate, R. L., & A. L. Bieber. 1978. Purification and characterization of Mojave (Crotalus scutulatus sculularus) toxin and its subunits. Arch. Biochem. Biophys., 189: 397-408.
Caterall, W. A. 1980. Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes. Ann. Rev. Pharmacol. Toxico., 20: 1543.
Chang, C. C. 1979. The action of snake venoms on nerve and muscle, p. 309-376. In C. Y. Lee, (ed.). Snake Venoms. Springer-Yerlag. Berlin.
Chang, C. c., & K. H. Tseng. 1978. Effect of crotamine, a toxin of South American rattlesnake venom on the sodium channel of murine skeletal muscle. Br. J. Pharmacol., 63: 551-559.
Chang, C. C., S. J. Hong, & M. J. Su. 1983. A study on the membrane depolarization of skeletal museles caused by a scorpion toxin, sea anemone toxin II and crotamine and the interaction between toxins. Br. J. Pharmacol., 79: 673-680.
Cheymol, J., J. M. Gonҫalves, F. Bourillet, & M. Roch-Arvciller. 1971. Action neuromusculaire comparée de la crotamine et du venin de Crotalus durissus terrificus varo crotaminicus. 1. Sur preparations neuromusculaires in situ. Toxicon, 9: 279-286.
Duchen, L. W., B. J. Excell, R. Patel, & B. Smith. 1975. Changes in motor end-pIates resulting from muscle fibre necrosis and regeneration. A light and electron microscopic study of the effects of the depolarizing fraction (cardiotoxin) of Dendroaspis jamesoni venom. J. Neurol. Sci., 21: 391-417.
Dufoureq, J., J. F. Faucon. E. Bernard, & M. Pezolet. 1982. Structure-function relationsh for cardiotoxins interacting with phospholipids. Toxicon, 20: 165-174.
Engel, A. G., & C. Biesecker. 1982. Complement activation in muscle fiber necrosis: Demonstration of the membrane attack complex of complement in necrotic fibers. Ann. Neurol., 12: 289-296.
Engle, C. M., R. R. Becker, T. Bailey, & A. L. Bieber. 1983. Characterization of two myotoxic proteins from venom of Crotalus viridis concolor. Fed. Proc., 42: 2187.
Fabiano, R., & A. T. Tu. 1981. Purification and biochemical study of viriditoxin, tissue damaging toxin, from prairie rattlesnake venom. Biochemistry. 20: 21-27.
Farber, J. L. 1981. The role of calcium in cell death. Life Sciences, 29: 1289-1295.
Farber, J. L. 1982. Membrane injury and calcium homeostasis in the pathogenesis of coagulative necrosis. Lab. Invest., 47: 114-123.
Fohlman, J., D. Eaker, E. Karlsson, & S. Thesleff. 1976. Taipoxin, an extremely potent presynaptic neurotoxin from the venom of the Australian snake taipan (Oxyuranus s. scutellarus). Isolation, characterization, quaternary structure and pharmacological properties. Eur. J. Biochem., 68: 457-469.
Fox, J. W., M. Elzinga, & A. T. Tu. 1979. Amino acid sequence and disulfide bond assignement of myotoxin a isolated from the venom of prairie rattlesnake (Crotalus viridis viridis). Biocemistry, 18: 618-684.
Ginn , F.L., J. D. Shelburne, & B. F. Trump. 1968. Disorders of cell volume regulation. 1. Effects of plasma membrane adenosine triphosphatase with ouabain. Amer. J. Pathol., 53: 1044-1071.
Gleason, M.L., G. V. Odell, & C. L. Ownby. 1983. Isolation and biological activity of viriditoxin and a viriditoxin variant from Crotalus viridis viridis. Toxin Rev., 2: 235-265.
Gopalakrishnakone, P., B. Hawgood, S. E. Holbrooke, N. A. Marsh, S. Santana de Sa, & A. T. Tu. 1980. Sites of action of mojave toxin isolated from the venom of the mojave rattlesnake. Sr. J. Pharmacol. 69: 421-431.
Gopalakrishnakone, P., D. W. Dempster, B. J. Hawgood, & H. Y. Elder. 1984. Cellular and mitochondrial changes induced in the structure of murine skeletal muscle by cratoxin, a neurotoxic phospholipase A2 complex. Toxicon, 22: 85-98.
Gulik-Krzywicki, T., M. Balerna, J.P. Vincent, & M. Lazdunski. 1981. Freeze-fracture study of cardiotoxin action on axonal membrane and axonal membrane lipid vesicles. Biochim. Biophys. Acta, 643: 101-114.
Gutiérrez, J. M. , & F. Cháves. 1980. Efectos proteolítico, hemorrágico y mionecrótico de los venenos de serpientes costarricenses de los géneros Bothrops, Crotalus y Lachesis. Toxicon, 18: 315-321.
Gutiérrez, J. M. , F. Cháves, R. Bolaños, L. Cerdas, E. Rojas, O. Arroyo, & E. Portilla. 1981. Neutralización de los efectos locales del veneno de Bothrops asper por un antiveneno polivalente. Toxicon, 19: 493-500.
Gutiérrez, J. M., C. L. Ownby, & G. V. Odell. 1984a. Isolation of a myotoxin from Bothrops asper venom: Partial characterization and action on skeletal muscle. Toxicon, 22: 115-128.
Gutiérrcz, J. M., C. L. Ownb y , & G. V. Odell. 1984b. Pathogenesis of myonecrosis induced by crude venom and a myotoxin of Bothrops asper. Exp. Molec. Pathol. (en prensa).
Habermann, E., & H. Breithaupt. 1978. The crotoxin complex-an example of biochemical and pharmacological protein complementation. Toxicon, 16: 19-30.
Harris, J.B., & M. A. Johnson. 1978. Further observations on the pathological responses of rat skeletal muscle to toxins isolated from the venom of the Australian tiger snake, Notechis scutatus scutatus. Clin. Exp. Pharmacol. Physiol., 5: 587-600.
Harris, J. B., & C.A. MacDonell. 1981. Phospholipase A. activity of notexin and its role in muscle damage. Toxicon, 19: 419-430.
Harris, J. B., & C. A. Maltin. 1982. Myotoxic activity of the crude venom and the principal neurotoxin taipoxin of the Australian taipan, Oxyuranus scutellatus. Br. J. Pharmacol., 76: 61-75.
Harris, J. B., M. A. Johnson, & E. Karlsson. 1975. Pathological responses of rat skeletal muscle to a single suhcutaneous injection of a toxin isolated from the venom of the Australian tiger snake, Notechis scutatus scutatus. Clin. Exp. Pharmacol. Physiol., 2: 383-404.
Harris, J. B., M. A. Johnson, & C. A. MacDonell. 1980. Muscle necrosis induced by some presynaptically active neurotoxins, p. 569-578. In D. Eaker & T. Wadstrom (cds.). Natural Taxins. Pergamon Press. Oxford.
Homma, M., & A. T. Tu. 1971. Morphology of local tissue damage in experimental snake envenomation. Br. J. Exp. Pathol., 52: 538-542.
Hong, S. J., & C. C. Chang. 1983. Potentiation by crotamine of the depolarizing effect of batrachotoxin, protoveratrine a and grayanotoxin I on the rat diaphragm. Toxicon, 21: 503-514.
Ishiura, S. 1981. Calcium-dependent proteolysis in living cells. Life Sciences, 29: 1079-1087.
Karlsson, E. 1979. Chemistry of protein toxins in snake venoms, p. 159-212. In C. Y. Lee (ed.). Snake Venoms. Springer-Verlag. Berlin.
Karlsson, E., D. Eaker, & L. Ryden. 1972. Purification of a presynaptic neurotoxin from the venom of the Australian tiger snake Notechis scutatus seutatus. Toxicon, 10: 405-413.
Klibansky, C., Y. London, A. Frenkel, & A. de Vries. 1968. Enhancing action of synthetic and natural basic polypeptides on erythrocyte-ghost phosphotipase A. Biochim. Biophys. Acta, 150: 15-23.
Laure, C. J. 1975. Die primarstruktur des crotamins. Hoppe-Seyler's Z. Physiol. Chem., 356: 213-215.
Mebs, D. 1978. Pharmacology of reptilian venoms. p. 487-560. In C. Gans (ed.). Biology of the Reptitia. Academic Press. London.
Mebs, D., Ehrenfeld, & Y. Samejima. 1 983. Local necrotizing effect of snake venoms on skin and muscle: Relationship to serum creatine kinase. Toxicon, 21: 393-404.
Mokri, B., & A. G. Engel. 1975. Duchenne dystrophy: Electron microseopic findings pointing to a basic or early ahnormality in the plasma membrane of the muscle fiber. Nurology, 25: 1111-1120.
Ng, R.H., & B. O. Howard. 1980. Mitocondria and sarcoplasmic reticulum as model targets for neurotoxic and myotoxic phospholipases A2. Proc. Nat. Acad. Sci. Wash., 77: 1346-1350.
Odell, C.Y., K. L. Eneff, C.L. Ownby, M.L. Cleason, J.M. Gutiérrez, S.A. Hudiburg, & T.R. Colberg. 1983. Characterization of venom myotoxins of Crotalus durissus durissus, the Central American rattlesnake. Fed. Proc., 42: 1811.
Ohsaka, A. 1979. Hemorrhagic, necrotizing and edema-forming effects of snake veneoms, p. 480-546. In C. Y. Lee (ed.). Snake Venoms. Springer-Verlag: Berlin.
Ownby, C. L., D. Cameron, &:. A. T. Tu. 1976. Isolation of myotoxic component from rattlesnake (Crotalus viridis viridis) venom. Electron microscopic analysis of muscle damage. Amer. J. Pathol., 85: 149-166.
Ownby, C.L., J. Bjamason, & A. T. Tu. 1978. Hemorrhagic toxins from rattlesnake (Crotalus atrox) venom. Pathogenesis of hemorrhage induced by three purified toxins. Amer. J. Pathol., 93: 201-218.
Ownby, C. L., J. M. Gutiérrez, T. R. Colberg, & G. V. Odell. 1982. Quantitation of myonecrosis induced by myotoxin a from prairie rattlesnake (Crotalus viridis viridis) venom. Toxican, 20: 877-885.
Pestronk, A., I. M. Parhad, D.B. Drachman, & D. L. Price. 1982. Membrane myopathy: Morphological simitarities to Duchenne muscular dystrophy. Muscle & Nerve, 5: 209-214.
Pluskal, M.G., J. B. Harris, R. J. Pennington, & D. Eaker. 1978. Some biochemical responses of rat skeletal muscle to a single subcutaneous injection of a toxin (notexin) isolated from the venom of the Australian tiger snake Notechis scutatus scutatus. Clin. Exp. Pharmacol. Physiol., 5: 131-141.
Publicover, S.J., C. J. Duncan, & J. L. Smith. 1977. Ultrastructural changes in muscle mitochondria "in situ", including the apparent development of internal septa, associated with the uptake and release of calcium. Cell Tissue Res., 185: 373-385.
Russell, F. E., P. R. Pattabhiraman, R. C. Schaeffer, N. Tamiya, & N. Maeda. 1978. Some properties of the venom of Crotalus viridis helleri. Toxicon, 16: 425.
Schanne, F.A.X., A. B. Kane, E.E. Young, & J. L. Farber. 1979. Calcium dependence of toxic cell death: a final common pathway. Science, 206: 700-702.
Trump, B. F., I. Berezesky, & A. Osornio-Vargas. 1981. Cell death and the disease process, p. 209-242. In I.D. Bowen & R. A. Loxkshin (eds.). Cell Death in Biology and Pathology. Chapman and Hall. London.
Tu, A.T. 1982. Chemistry of rattlesnake venoms, p. 24 7-312. In A. T. Tu (ed.). Rattlesnake Venoms, Their Actions and Treatment. Marcel Dekker: New York.
Vital-Brazil, O., J. Prado-Francesehi, & C. J. Laure. 1979. Repetitive muscle responses induced by crotamine. Toxicon, 17: 61-67.
Wrogemann, K., & S. D. J. Pena. 1976. Mitochondrial calcium overload: a general mechanism for cell-necrosis in muscle diseases. Lancet, 1: 672-673.
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