Abstract
White rats were found to be resistant to 3 x 107 Toxoplasma gondii organisms (RH strain) inoculated either s.c or i.p. That resistance was age-dependent since survival time of 1- or 5-day-old rats inoculated with 104 or 106 tachyzoites was lower as compared with those 10 or 15 days old. Organisms kept in contact with a lysate of white rat complete peritoneal exudate showed reduced capacity to infect mice. Peritoneal exudate of 5 -day-old rats showed a stronger effect than that of 1, 2, 3, or 4 day-infected animals. After 10 days the anti-toxoplasma effect diminished and it almost disappeared after 15 days of infection. Apparently age and macrophage activity are very important factors in the natural adaptability of the white rat to Toxoplasma gondii.References
Anderson, S.E., & J.S. Remington. 1974. Effect of normal and activated human macrophages on Toxoplasma gondii. J. Exp. Med., 139: 1154-1174.
Borges, J.S., & W.D. Johnson. 1975. Inhibition of multiplication of Toxoplasma gondii b y human monocytes exposed to T-lymphocyte products. J. Exp. Med., 141: 483-496.
Cline, MJ., R.I. Lehrer, M.C. Territo & D.W. Golde. 1978. Monocytes and macrophages: Functions and diseases. Ann. 1nt. Med., 88: 78-88.
Frenkel, J.K. 1953. Host, strain and treatment variation as factors in the pathogenesis of toxoplasmosis. Amer. J. Trop. Med. Hyg., 2: 390-415.
Harboe, A., &. S. Erichsen. 1954. Toxoplasmosis in chickens 3. Attempts to provoke a systemic disease in chickens by infection with a chicken strain and a human strain of toxoplasma. Acta. Path. Microbiol. Scand., 35: 495-502.
Hill, A.B. 1966. PrincipIes of medical statistics. 8th ed. Oxford University Press, New York p. 143-151.
Hoff, R.L. & J.K. Frenkel. 1974. Cell mediated immunity against Besnoitia and Toxoplasma in specifically and cross immunized hamsters and in cultures. J. Exp. Med., 139: 560-580.
Jacobs, L. 1956. Propagation, morphology and biology of Toxoplasma. Ann. N.Y. Acad. Sci., 64: 154-179.
Klebanoff, SJ. Myeloperoxidase halide-hydrogen peroxide antibacterial systern. J . Bacteriol., 95: 2131-2138.
Lainson, R. 1955. Toxoplasrnosis in England II. Variation factors in the pathogenesis of Toxoplasma infections: the sudden increase in virulence of a strain after passage in rnultirnarnrnate rats and canaries. Ann. Trop. Med. Parasit., 49: 384-416.
Lewis, W.P., & E.K. Markel. 1958. Adquisition of immunity to toxoplasmosis by the newborn rato Exp. Parasit., 7: 463-467.
Lindberg, R.E., & J.K. Frenkel. 1977. Cellular immunity to Toxoplasma and Besnoitia in hamsters : specificity and the effects of cortisol. lnfect. lmmun., 15: 855-862.
Perrin, T.L., GD. Brighrnan, & E.G. Pickens. 1943. Toxoplasmosis in wild rats. I. Inf. Dis., 72: 91-96.
Remington, J.S., J.L. Krahenbuhl, & J.W. Mendenhall. 1972. A role for activated macrophages in resistance to infection with Toxoplasma. Infec. Immun., 6: 829-834.
Ruchman, T., & J.C. Fowler 1951. Localization and persistance of Toxoplasma in tissues of experimentally infected white rats. Proc. Soc. Exptl. Biol. Med., 76 : 793-796.
Sabin, A.B., & H.A. Feldman. 1948. Dyes as microchemical indicators of a new immunity phenomenon affecting a protozoon parasite (Toxoplasma). Science, 108: 660-663.
Shirahata, T., K. Shimizu, & N. Suzuki. 1976. Effect of immune lyrnphocyte products and serum antibody on the multiplication of Toxoplasma in murine peritoneal macrophages. Z . Parasitenk, 49: 11-23.
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Copyright (c) 1981 Revista de Biología Tropical