Abstract
Lyophilized Bothrops asper venom was assayed on toad heart in situ and frog heart in vitro to study cardiac abnormalities in the frequency, inotropic effect and arrhythmia. Heated venom was also used to test the effect of lower toxic molecular weight components.
With either crude or heated venom the cardiac frequency was decreased, with a marked negative inotropic effect in the toad heart, which showed in several cases 2: 1 heart block.
References
Abel, J. H., Jr., A. W. Nelson, & C. A. Bonilla 1973. Crotalus adamanteus basic protein toxin: electron microscopic evaluation of miocardial damage. Toxicon, 11: 59.
Amuchastegui, S. R. 1940. Action du venin de Bothrops alternatus sur le coeur et la dynamique circulatoire. CR. Soc. Biol. Paris, 133: 317-319.
Badano, B. N., & A. O. M. Stoppani 1964. The action of Bothrops yenom on the Keilin-Hartree heart muscle preparation. Biochem. Pharmacol., 13: 793-795.
Bhanganada, K., & J. F. Perry, Jr. 1963. Cardiovascular effects of cobra venom. 1. J. A mer. Med. Ass., 183: 125-259.
Brown, R. V. 1940. The action of water moccasin venoms on the isolated frog heart. Amer. J. Physiol., 130: 613-619.
Chang, C. C., & C. Y. Lee 1966. Electrophysiological study of neuromuscular blocking action of cobra neurotoxin. Brit. J. Pharmacol., 28: 172-181.
Cohen, M., & G. B. Sumyk 1966. Cardiovascular and respiratory effects of cobra venom and a venom fradion. Toxicon, 3: 291-295.
Devi, A. 1968. The protein and nonprotein constituents of snake venoms, p. 119-165. In W. Bücherl, E. E. Buckley & V. Deulofeu (eds), Venomous animals and their venoms. Vol. 1. Academic Press, New York.
Dutra de Oliveira, J. 1932. Action of snake venoms on the heart. Brazil Med., 46: 265.
Essex, H. E., & J. Markowitz 1930. The physiology of rattlesnake venom (Crotalinl. VII. The similarity of crotalin shock and anaphylactic shock. Amer. J. Physiol., 92: 698-704.
Jiménez-Porras, J. M. 1968. Pharmacology of peptides and proteins in snake venoms. Ann. Rev. Pharmacol., 8: 299-318.
Jiménez-Porras, J. M. 1970. Biochemistry of snake venoms. Clin. Toxicology, 3: 389-431.
Matsusaki, K., K. Doono, H. Nakao, & T. Toriyama 1961. Effect of Trimeresurus venom on electrical activity of single ventricular muscle fiber of chicken. Med. J. Kagoshima Univ., 13: 153-157.
Morales, O. 1969. Manual de prácticas de fisiología. Departamento de Publicaciones, Universidad de Costa Rica, 144 pp.
Morales, O. 1970. A lteraciones cardio vasculares y respiratorias producidas en el perro por dosis sub letales de veneno de Bothrops atrox, por vía intraperitoneal e intramuscular. Tesis, Lic. Biología Universidad de Costa Rica. 82 pp.
Radomsky, J . L., & W. B. Deichmann 1957. Comparative pharmacological studies of Crotalus adamanteus and Naja flava venoms. Fed. Proc., 16: 328-329.
Soaje-Echague, E. 1940. Alteraciones circulatorias producidas por el veneno de Crotalus terrificus. Rev. Soc. Argent. Biol., 16: 475-479.
Russell, F. E., & B. A. Michaelis 1960. Cardiovascular effects of Crotalus venom. 1. Med. Arts Sci., 14: 119-121.
Russell, F.. E. & R. S. Scharffenberg 1964. Bibliography of snake venoms and venomous snakes. Bibliographic Assoc., Inc. West Covina, California. 220 pp.
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