How to Cite
Abstract
A comparative study of the effects produced by histamine on 15 different sections of the small intestine of hamsters (Cricetus auratus) from the stomach to the ileocecal valve was performed to find a substitute for that of guinea pigs and to ascertain which of the sections was the most sensitive.
Changes in tone, amplitude and frequency of contractions with respect to control (spontaneous motility ) were significant (P < 0.01); the variance analysis showed no significant variations in the sensitivity or the motility of the different sections.
References
DIXON, W. J, & A. M. MOOD 1946. The statistical sign test. J. Amer. Stalist. Ass., 41: 557-566.
EICHBAUM, F. W., & Z. BRUNO 1968. Effect of smooth muscle stilnulating substances on different segments of the guinea pig ileum. Pharmacology (Basel), 1: 241-245.
GOSSELIN, R. E. & R. S. GOSSELIN 197). Tachyphylaxis of guinea-pig ileum to histamine and furtrethoruum. J. Pharmacol. Exp. Tber., 184: 494-505.
HENDERSON, P. T., E. J. ARIENS & A. M. SIMONIS 1968. Differentiation of various types of cholinergic and other spasmogenic actions on the isolated guinea-pig ileum. Europ. J. Pharmacol., 4: 62-70.
MILLER, L. C., T. J. BECKER, & M. L. TAINTER 1948. The quantitative evaluation of spasmolytic drugs in vitro. J. Pharmacol. Exp. Ther., 92: 260-268.
SNEDECOR, G. W., & W. G. COCHRAN 1956. Stadistical methods applied lo experimenls in agriculture and biology. The Iowa State College Press, Ames, Iowa. 534 P.P.
UNIVERSITY OF EDINBURGH. STAFF OF THE DEPARMENT OF PHARMACOLOGY 1970. Pharmacological experiments on isolaled preparations. E. & S. Livingstone. Edinburgh and London. 2° ed. 62 p.p.
##plugins.facebook.comentarios##
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 1975 Revista de Biología Tropical