Weight losses and urine osmolarity in the hypophysectomized-adrenalectomized albino rat

Abstract

Body weight los s in doubly endocrinectomized albino rats was higher than in adrenalectomized or hypophysectomized rats alone. Frequent body weight checks to adjust the dosages on a per weight basis for chronic experiments are suggested.

The urine osmolarity in these rats was hypertonic, 965.33 mOsm/1, and close to that of normal rats: 1.119 mOsm/l. This finding is explained by reorganization of the neurohypophysis following hypophysectomy and ADH release into the blood stream directly from hypothalamic nuclei stimulated by a slightly hypertonic plasma.