Tumores benignos y displasias de la mama

Abstract

A study is presented of 369 cases of benign tumors and displasia of the breast recorded in the years 1939-53 in Hospital San Juan de Dios and Hospital Central de la Caja del Seguro Social, in San José, Costa Rica. Of this number, 354 occurred in women and 15 in men. The histologic types found were fibroadenoma, fibroma, fibromixoma, adenoma, intraductal papiloma and chronic cystic mastitis. The following aspects are considered in the cases occurring in women: a) histopathologic incidence and its relation to age and the number of parturitions and abortions b) location c) correlation between clinic and histopathologic diagnoses d) casuistic in Negro women The cases occurring in males are considered; the prevailing type in them being fibroadenoma. A detailed discussion of the histopathogenesis of these tumors is present­ed, leading to the following conclusions: 1) Intracanalicular fibroadenoma, fibroma, and fibromyxoma are probably hyperplasias, predominantly connectival, due to chronic moderate hyper­ foliculinemia, whiIe pericanalicular fibroadenoma could be a connectival­parenchymatous hyperplasia dae to acute hyperfoliculinemia. 2) Chronic cystic mastitis, intraductal papiloma, and pure adenoma appear to be displasias of "correlative-endocrine" origin, due to an unbalance of the suprarenal cortex, resulting in trophic alterations of mammary tis­ sues, especially the connective. The following investigations are suggested as convenient in this type of diseases: a) routine determination of ovaric hormone content in the blood b) periodic cytological study of vaginal smears c) histochemical analysis of hypophysis, breast, ovaries, and saprarenal glands in autopsies.