Resumen
En anfibios, a nivel mundial esta ocurriendo una disminución de las poblaciones y sus causas varían entre regiones, con la disrupción endocrina inducida por contaminantes como una de las causas que frustra el crecimiento poblacional. En reptiles, las poblaciones locales de lagartos han sido reducidas drásticamente por exposición directa a sustancia toxicas y su recuperación ha sido demorada probablemente por disrupción sexual, particularmente por la feminización inducida por exposición crónica a contaminantes. En contraste, tortugas lagarto altamente contaminadas muestran características sexuales secundarias feminizadas, evidencia de desarrollo sexual alterado, pero las poblaciones son más numerosas en los sitios más contaminados. En aves, el decrecimiento de las poblaciones y su recuperación han sido directamente ligadas con la exposición a residuos de p, p-DDE a través del adelgazamiento de la cáscara del huevo y con la prohibición del uso del compuesto DDT en USA y Europa. Aves depredadoras regionales todavía sufren mortalidad de polluelos relacionada con cargas de PCB y DDT, pero no han sido demostrados vínculos causales con procesos mediados via endocrina. En mamíferos, han sido documentados desórdenes hormonales inducidos por contaminantes en focas y osos polares, pero no hay evidencia directa que ligue efectos endocrinos con la disminución de las poblaciones. No obstante que la disrupción endocrina raramente es la única causa de fallos en reclutamiento o disminución de las abundancias, puede ser un saboteador sutil del desarrollo sexual, tasa de sexos, y compensación metabólica ante el estrés ambiental. La disrupción endocrina es poco probable que llegue a extirpar una especie de su ámbito entero, pero en combinación con otros tensores como pérdida de habitat, extracción excesiva, y cambio climático global, podría contribuir a extinciones locales.Citas
Ackermann, G., J. Schwaiger, R. Negele & K. Fent. 2002. Effects of long-term nonylphenol exposure on gonadal development and biomarkers of estrogenicity in juvenile rainbow trout (Oncorhynchus mykiss). Aquat. Toxicol. 60: 203-221.
Bergeron, J.M., D. Crews & J.A. McLachlan. 1994. PCBs as environmental estrogens: Turtle sex determination as a biomarker of environmental contamination. Env. Health Perspect. 102: 780-781.
Bergeron, J.M., E. Willingham, C. Osborn, T. Rhen & D. Crews. 1999. Developmental synergism of steroidal estrogens in sex determination. Env. Health Perspect. 107: 93-97.
Bortone, S.A., W.P. Davis & C.M. Bundrick. 1989. Morphological and behavioral characters in mosquitofish as potential bioindication of exposure to kraft mill effluent. Bull. Environ. Contam. Toxicol. 43: 370-377.
Bowerman, W., D. Best, T. Grubb, J. Sikarskie & J. Giesy. 2000. Assessment of environmental endocrine disruptors in bald eagles in the Great Lakes. Chemosphere 41: 1569-1574.
Brouwer, A., D.C. Morse, M.C. Lans, A.G. Schuur, A.J. Murk, E. Klasson-Wehler et al. 1998. Interactions of persistent environmental organohalogens with the thyroid hormone system: Mechanisms and possible consequences for animal and human health. Toxicol. Indust. Health 14: 59-84.
Bustnes, J., V. Bakken, K. Erikstad, F. Mehlum & J. Skaare. 2001. Patterns of incubation and nest-site attentiveness in relation to organochlorine (PCB) contamination in glaucous gulls. J. Appl. Ecol. 38: 791-801.
Daston, G., J. Cook & R. Kavlock. 2003. Uncertainties for endocrine disrupters: our view on progress. Toxicol. Sci. 74: 245-252.
Dawson, A. 2000. Mechanisms of endocrine disruption with particular reference to avian wildlife: a review. Ecotoxicology 9: 59-69.
de Solla, S., C. Bishop, G. Van Der Kraak & R. Brooks. 1998. Impact of organochlorine contamination on levels of sex hormones and external morphology of common snapping turtles (Chelydra serpentina serpentina). Env. Health Perspect. 106: 253-260.
de Solla, S., C. Bishop & R. Brooks. 2002. Sexually dimorphic morphology of hatchling snapping turtle (Chelydra serpentina) from contaminated and reference sites in the Great Lakes and St. Lawrence River basin, North America. Environ. Toxicol. Chem. 21: 922-929.
Denton, T., W.M. Howell, J. Allison, J. McCollum & B. Marks. 1985. Masculinization of female mosquitofish by exposure to plant sterols and Mycobacterium smegmatis. Bull Environ Contam Toxicol 35: 627-632.
Derocher, A., H. Wolkers, T. Colborn, M. Schlabach, T. Larsen & O. Wiig. 2003. Contaminants in Svalbard polar bear samples archived since 1967 and possible population level effects. Sci. Tot. Environ. 301: 163-174.
Dube, M. & D. MacLatchy. 2000. Endocrine responses of Fundulus heteroclitus to effluent from a bleachedkraft pulp mill before and after installation of reverse osmosis treatment of a waste stream. Environ. Toxicol. Chem. 19: 2788-2796.
Environmental Protection Agency. 2004. Florida NPL/NPL caliber cleanup site: Tower Chemical.
Fentress, J., S. Steele, H. Bart Jr. & A. Cheek. 2006. Reproductive disruption in wild longear sunfish (Lepomis megalotis) exposed to paper mill effluent. Environ. Health Perspect. 114: 40-45.
Flouriot, G., F. Pakdel, B. Ducouret & Y. Valotaire. 1995. Influence of xenobiotics on rainbow trout liver estrogen receptor and vitellogenin gene expression. J. Mol. Endocrinol. 15: 143-151.
Fox, G. 1991. Practical causal inference for ecoepidemiologists. J. Toxicol. Env. Health 33: 359-373.
Fry, D.M. & C.K. Toone 1981. DDT-induced feminization of gull embryos. Science 213: 922-924.
Guillette, L.J. & D.A. Crain. 1995. Endocrine-disrupting contaminants and reproductive abnormalities in reptiles. 5 p.
Guillette, L.J., T.S. Gross, G.R. Masson, J.M. Matter, H.F. Percival & A.R. Woodward. 1994. Developmental abnormalities of the gonad and abnormal sex hormone concentrations in juvenile alligators from contaminated and control lakes in Florida. Env. Health Perspect. 102: 680-688.
Gunderson, M., G. LeBlanc & L. Guillette. 2001. Alterations in sexually dimorphic biotransformation of testosterone in juvenile American alligators (Alligator mississippiensis) from contaminated lakes. Environ Health Perspect. 109: 1257-1264.
Hanson, N., P. Aberg & A. Sudelof. 2005. Population-level effects of male-biased broods in eelpout (Zoarces viviparus). Environ. Toxicol. Chem. 24: 1235-1241.
Hart, C., I. Nisbet, S. Kennedy & M. Hahn. 2003. Gonadal feminization and halogenated environmental contaminants in common terns (Sterna hirundo): Evidence that ovotestes in male embryos do not persist to the prefledgling stage. Ecotoxicology 12: 125-140.
Hashimoto, S., H. Bessho, A. Hara, M. Nakamura, T. Iguchi & K. Fujita. 2000. Elevated serum vitellogenin levels and gonadal abnormalities in wild male flounder (Pleuronectes yokohamae) from Tokyo Bay, Japan. Mar. Environ. Res. 49: 37-53.
Hayes, T., K. Hason, M. Tsui, A. Hoang, C. Haeffele & A. Vonk. 2003. Atrazine-induced hermaphroditism at 0.1 ppb in American leopard frogs (Rana pipiens): Laboratory and field evidence. Environ. Health Perspect. 111: 568-575.
Hewitt, M., J. Parrott, K. Wells, M. Calp, S. Biddiscombe, M. McMaster et al. 2000. Characteristics of ligands for the Ah receptor and sex steroid receptors in hepatic tissues of fish exposed to bleached kraft mill effluent. Environ Sci Technol 34: 4327-4334.
Hewitt, M., S. Smyth, M. Dube, C. Gilman & D. MacLatchy. 2002. Isolation of compounds from bleached kraft mill recovery condensates associated with reduced levels of testosterone in mummichog (Fundulus heteroclitus). Environ. Toxicol. Chem. 21: 1359-1367.
Howell, W.M., D.A. Black & S.A. Bortone. 1980. Abnormal expression of secondary sex characters in a population of mosquitofish, Gambusia affinis holbrooki: Evidence for environmentally-induced masculinization. Copeia 4: 676-681.
Hurley, M., P. Matthiessen & A. Pickering. 2004. A model for environmental sex reversal in fish. J. Theoret. Biol. 227: 159-165.
IUCN. 2004. Conservation Trust, Nature Serve. Global amphibian assessment. Jenkins R. 2001. Identification of androstenedione in a river containing paper mill effluent. Env. Toxicol. Chem. 20: 1325-1331.
Jenkins, R., E. Wilson, R. Angus, W. Howell & M. Kirk. 2003. Androstenedione and progesterone in the sediment of a river receiving paper mill effluent. Toxicol. Sci. 73: 53-59.
Jenkins, R., E. Wilson, R. Angus, W. Howell, M. Kirk, R. Moore, et al. 2004. Production of androgens by microbial transformation of progesterone in vitro: A model for androgen production in rivers receiving paper mill effluent. Environ Health Perspect 112: 1508-1511.
Jobling, S., & J.P. Sumpter. 1993. Detergent components in sewage effluent are weakly oestrogenic to fish: An in vitro study using rainbow trout (Oncorhynchus mykiss) hepatocytes. Aquatic Toxicol. 27: 361-372.
Jobling, S., T. Reynolds, R. White, M.G. Parker & J.P. Sumpter. 1995. A variety of environmentally persistent chemicals, including some phthalate plasticizers, are weakly estrogenic. Environ. Health Perspect. 103: 582-587.
Jobling, S., N. Beresford, M. Nolan, T. Rodgers-Gray, G. Brighty, J. Sumpter et al. 2002. Altered sexual maturation and gamete production in wild roach (Rutilus rutilus) living in rivers that receive treated sewage effluents. Biol. Reprod. 66: 272-281.
Kannan, K., M. Ueda, J. Shelby, M. Mendonca, M. Kawano, M. Matsuda et al. 2000. Polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), biphenyl (PCBs), and organochlrine pesticides in yellow- blotched map turtle from the Pascagoula River bain, Mississippi, USA. Arch. Environ. Contam. Toxicol. 38: 362-370.
Karels, A., E. Markkula & A. Oikari. 2001. Reproductive, biochemical, physiological and population responses in perch (Perca fluviatilis L.) and roach (Rutilus rutilus) downstream of two elemental chlorine free pulp and paper mills. Env. Toxicol. Chem. 20: 1517-1527.
Karels, A., M. Soimasuo, J. Lappivaara, H. Leppanen, T. Aaltonen, P. Mellanen et al. 1998. Effects of ECFbleached draft mill effluent on reproductive steroids and liver MFO activity in populations of perch and roach. Ecotoxicol. 7: 123-132.
Kavanagh, R., G. Balch, Y. Kiparissis, A. Niimi, J. Sherry, C. Tinson et al. 2004. Endocrine disruption and altered gonadal development in white perch (Morone americana) from the lower Great Lakes region. Environ. Health Perspect. 112: 898-902.
Kirby, M., J. Bignell, E. Brown, J. Craft, I. Davies, R. Dyer et al. 2003. The presence of morphologically intermediate papilla syndrome in United Kingdom populations of sand goby (Pomatoschistus spp.): Endocrine disruption? Env. Toxicol. Chem. 22: 239-251.
Kirby, M., Y. Allen, R. Dyer, S. Feist, I. Katsiadaki & P. Matthiessen et al. 2004. Surveys of plasma vitellogenin and intersex in male flounder (Platichthys flesus) as measures of endocrine disruption by estrogenic contamination in United Kingdom estuaries: temporal trends, 1996 to 2001. Environ. Toxicol. Chem. 23: 748-758.
Larsson, D., H. Hallman & L. Forlin 2000. More male fish embryos near a pulp mill. Env. Toxicol. Chem. 19: 2911-2917.
Larsson, D. & L. Forlin. 2002. Male-biased sex ratio of fish embryos near a pulp mill: temporary recovery after a short-term shutdown. Env. Health Perspect. 110:739-742.
Lavado, R., R. Thibaut, D. Raldua, R. Martin & C. Porte. 2004. First evidence of endocrine disruption in feral carp from the Ebro River. Toxicol. Appl. Pharmacol. 196: 247-257.
Le Boeuf, B., J. Giesy, K. Kannan, N. Kajiwara, S. Tanabe & C. Debier. 2002. Organochloride pestsicides in California sea lions revisited: BMC Ecology 2: 11.
Lister, A. & G. Van Der Kraak. 2001. Endocrine disruption: Why is it so complicated? Water Qual. Res. J. Canada 36: 175-190.
Lorenzen, A., T. Moon, S. Kennedy & G. Fox. 1999. Relationships between environmental organochlorine contaminant residues, plasma corticosterone concentrations, and intermediary metabolic enzyme activities in Great Lakes herring gull embyros. Environ. Health Perspect. 107: 179-186.
Lundholm, C. 1997. DDE-induced eggshell thinning in birds: Effects of p,p’-DDE on the calcium and prostaglandin metabolism of the eggshell gland. Comp. Biochem. Physiol. Pharmacol. Toxicol. Endocrinol. 118: 113-128.
Matter, JM, D.A. Crain, C. Sills-McMurry, D.B. Pickford, T.R. Rainwater & K.D. Reynolds et al. 1998. Effects of endocrine disrupting contaminants in reptiles: alligators. p. 267-289. In R. Kendall, R. Dickerson, J. Giesy, W. Suk (eds.). Principles and Processes for Evaluating Endocrine Disruption in Wildlife. Pensacola FL: SETAC, 267-289.
McNabb, F. & G. Fox. 2003. Avian thyroid development in chemically contaminated environments: is there evidence of alterations in thyroid function and development? Evol. Dev. 5: 76-82.
Mills, L. & C. Chichester. 2005. Review of evidence: Are endocrine-disrupting chemicals in the aquatic environment impacting fish populations? Sci. Tot. Environ. 343:1-34.
Munkittrick, K., M. McMaster, L. McCarthy, M. Servos & G.J. Van Der Kraak. 1998. An overview of recent stu dies on the potential of pulp-mill effluents to alter reproductive parameters in fish. J. Toxicol. Environ. Health B 1: 347-371.
Munkittrick, K.R., G.J. Van Der Kraak, M.E. McMaster & C.B. Portt. 1992. Response of hepatic MFO activity and plasma sex steroids to secondary treatment of bleached kraft pulp mill effluent and mill shutdown. Environ. Toxicol. Chem. 11: 1427-1439.
Orlando, E., W. Davis & L. Guillette. 2002. Aromatase activity in the ovary and brain of the Eastern mosquitofish (Gambusia holbrooki) exposed to paper mill effluent. Environ. Health Perspect. 110 (Suppl. 3): 429-433.
Ormerod, S., S. Tyler & I. Juttner. 2000. Effects of pointsource PCB contamination on breeding performance and post-fledgling survival in the dipper Cinclus cinclus. Environ. Pollut. 110: 505-513.
Parks, L., C. Lambright, E. Orlando, L.J. Guillette, G. Ankley & L.J. Gray. 2001. Masculinization of female mosquitofish in kraft mill effluent-contaminated Fenholloway River water is associated with androgen receptor agaonist activity. Toxicol. Sci. 62: 257-267.
Pechmann, J.H.K., D.E. Scott, R.D. Semlitsch, J.P. Caldwell, L.J. Vitt & J.W. Gibbons. 1991. Declining amphibian populations: The problem of separating human impacts from natural fluctuations. Science 253: 892-895.
Podreka, S., A. Georges, B. Maher & C. Limpus. 1998. The environmental contaminant DDE fails to influence the outcome of sexual differentiation in the marine turtle Chelonia mydas. Environ. Health Perspect. 106: 185-188.
Purdom, C.E, P.A. Hardiman, V.J. Bye, N.C. Eno, C.R. Tyler & J.P. Sumpter. 1994. Estrogenic effects of effluents from sewage treatment works. Chem. Ecol. 8: 275-285.
Reeder, A., G. Foley, D. Nichols, L. Hansen, B. Wikoff, S. Faeh et al. 1998. Forms and prevalence of intersexuality and effects of environmental contaminants on sexuality in cricket frogs (Acris crepitans). Environ. Health Perspect. 106: 261-266.
Reeder, A., M. Ruiz, A. Pessier, L. Brown, J. Levengood, C. Phillips et al. 2005. Intersexuality and the cricket frog decline: historic and geographic trends. Environ. Health Perspect. 113: 261-265.
Rodgers-Gray, T., S. Jobling, C. Kelly, S. Morris, G. Brighty, M. Waldock, et al. 2001. Exposure of juvenile roach (Rutilus rutilus) to treated sewage effluent induces dose-dependetn and persisten disruption in gonadal duct development. Environ. Sci. Technol. 35: 462-470.
Safe, S. & V. Krishnan. 1995. Chlorinated hydrocarbons: estrogens and antiestrogens. Toxicol. Lett. 82/83: 731-736.
Safe, S. & M. Wormke. 2003. Inhibitory aryl hydrocarbon receptor-estrogen receptor a cross-talk and mechanisms of action. Chem. Res. Toxicol. 16: 807-816.
Sanderson, J., R. Letcher, M. Heneweer, J. Giesy & M. van den Berg. 2001. Effects of chloro-s-triazine herbicides and metabolites on aromatase activity in various human cell lines and on vitellogenin production in male carp hepatocytes. Environ. Health Perspect. 109: 1027-1031.
Seki, M., H. Yokota, M. Maeda, H. Tadokoro & K. Kobayashi. 2003. Effects of 4-nonylphenol and 4- tert-octylphenol on sex differentiation and vitellogenin induction in medaka (Oryzias latipes). Env. Toxicol. Chem. 22: 1507-1516.
Sepulveda, M., D. Ruessler, N. Denslow, S. Holm, T. Schoeb & T. Gross. 2001. Assessment of reproductive effects in largemouth bass (Micropterus salmoides) exposed to bleached/unbleached kraft mill effluents. Arch. Environ. Contam. Toxicol. 41: 475-482.
Sepulveda, M., B. Quinn, N. Denslow, S. Holm & T. Gross. 2003. Effects of pulp and paper mill effluents on reproductive success of largemouth bass. Environ. Toxicol. Chem. 22: 205-213.
Sheahan, D., G. Brighty, M. Daniel, S. Jobling, J. Harries, M. Hurst et al. 2002. Reduction in the estrogenic activity of a treated sewage effluent discharge to an English river as a result of a decrease in the concentration of industrially derived surfactants. Env. Toxicol. Chem. 21: 515-519.
Shelby, J. & M. Mendonca. 2001. Comparison of reproductive parameters in male yellow-blotched map turtles (Graptemys flavimaculata) from a historically contaminated and a reference site. Comp. Biochem. Physiol. C. Toxicol. Pharmacol. 129: 233-242.
Spongberg, A. 2004. PCB contamination in surface sediments in the coastal waters of Costa Rica. Rev. Biol. Trop. 52 (Suppl. 2): 1-10.
Spongberg, A. 2006. PCB concentrations in Sipunculan marine worms in the coastal waters of western Costa Rica. Rev. Biol. Trop. 54 (Suppl. 1): 27-33.
Stoker, C., F. Rey, H. Rodríguez, J. Ramos, P. Sirosky, A. Larriera et al. 2003. Sex reversal effects on Caiman latirostris exposed to environmentally relevant does of the xenoestrogen bisphenol A. Gen. Comp. Endocrinol. 133: 287-296.
Tennant, M., D. Hill, J. Eldridge, L. Wetzel, C. Breckendridge & J. Stevens. 1994. Chloro-s-triazine antagonism of estrogen action: limited interaction with estrogen receptor. J. Toxicol. Environ. Health 43: 197-211.
Vonier, P.M., D.A. Crain, J.A. McLachlan, L.J. Guillette & S.F. Arnold. 1996. Interaction of environmental chemicals with the estrogen and progesterone receptors from the oviduct of the American alligator. Env. Health Pespect. 104: 1318-1322.
Wake, D.B. 1991. Declining amphibian populations. Science 253: 860. Weed, D. 2002. Environmental epidemiology: Basics and proof of cause-effect. Toxicology 181-182: 399-403.
Willingham, E., T. Rhen, J. Sakata & D. Crews. 2000. Embryonic treatment with xenobiotics disrupts steroid hormone profiles in hatchling red-eared slider turtles (Trachemys scripta elegans). Env. Health Perspect. 108: 329-332.
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