Resumen
Lippia alba es una especie aromática perteneciente a la familia Verbenaceae, cuyos aceites esenciales han sido empleados en diferentes industrias dada sus propiedades biológicas. Objetivo: identificar las perspectivas de aplicación biotecnológica de los aceites esenciales de Lippia alba. Métodos: se realizó una revisión sistemática exploratoria de la literatura sobre la actividad biológica de aceites esenciales de Lippia alba registrada hasta octubre 2018 en las bases de datos EBSCO, Embase, Scopus y Lilacs. Resultados: los quimiotipos I y III han sido reportados para diferentes actividades biológicas a partir de evaluaciones realizadas en microorganismos, peces, artrópodos, pequeños mamíferos, y líneas celulares; fundamentalmente asociadas con efectos antibacterial, antifúngico, citotóxico, antioxidante y sedante, entre otros. Los registros se enfocaron principalmente a los sectores salud, industria pesquera y agroalimentaria. Conclusión: los estudios sobre el efecto del aceite esencial son promisorios, pero no reflejan una continuidad de la investigación hacia prototipos o productos comerciales acabados. Los grupos de investigación deben unificar metodologías de evaluación e incluir en todos los estudios la relación entre fitoquímica-actividad biológica, para que los metaanálisis sean posibles. De igual manera, deben aunar esfuerzos por medio del Sistema Nacional de Innovación Agropecuaria (SNIA), para generar productos acabados que impacten en la sociedad y faciliten el avance de la bioeconomía del país.
Citas
Agudelo-Gómez, L.S., Gómez, G.A., Durán, D.C., Stashenko, E., & Betancur-Galvis, L. (2010). Composición química y evaluación de la actividad antiherpética in vitro de aceites esenciales de Lippia alba (Mill) N.E. Brown y sus componentes mayoritarios. Salud UIS, 42(3), 230-239.
Aldana, F., & Cruz, S. (2017). Larvicidal activity of essential oils of Lippia alba and Lippia graveolens, on Aedes aegypti L. Revista Cientifica, 26(2), 36-48.
Almeida, A.P.G., Heinzmann, B.M., Val, A.L., & Baldisserotto, B. (2018). Essential oils and eugenol as anesthetics for Serrasalmus rhombeus. Boletim Do Instituto de Pesca, 44(1), 44-50.
Anaruma, N.D., Schmidt, F.L., Duarte, M.C.T., Figueira, G.M., Delarmelina, C., Benato, E.A., … Sartoratto, A. (2010). Control of Colletotrichum gloeosporioides (penz.) Sacc. In yellow passion fruit using Cymbopogon citratus essential oil. Brazilian Journal of Microbiology, 41(1), 66-73.
Armstrong, R., Hall, B.J., Doyle, J., & Waters, E. (2011). “Scoping the scope” of a cochrane review. Journal of Public Health, 33(1), 147-150.
Aular, Y., Villamizar, M., Pérez, Y., & Pérez, V. (2016). Composición química y toxicidad aguda oral del aceite esencial de Lippia alba en ratones. Salus, 20(1), 43-51.
Azambuja, C.R., Mattiazzi, J., Riffel, A.P.K., Finamor, I.A., Garcia, L.O., Heldwein, C.G., … Llesuy, S.F. (2011). Effect of the essential oil of Lippia alba on oxidative stress parameters in silver catfish (Rhamdia quelen) subjected to transport. Aquaculture, 319(1), 156-161. DOI: https://DOI.org/10.1016/j.aquaculture.2011.06.002.
Baldissera, M.D., Souza, C., Mourão, R.H.V., Silva, L.V.F., & Monteiro, S.G. (2017). Trypanocidal action of Lippia alba and Lippia origanoides essential oils against Trypanosoma evansi in vitro and in vivo used mice as experimental model. Journal of Parasitic Diseases, 41(2), 345-351. DOI: https://DOI.org/10.1007/s12639-016-0800-7.
Barrientos, J.C., Reina, M.L., & Chacón, M.I. (2012). Potencial económico de cuatro especies aromáticas promisorias para producir aceites esenciales en Colombia. Revista Colombiana De Ciencias Hortícolas, 6(2), 225-237.
Batista, E., Brandão, F.R., Majolo, C., Inoue, L.A.K.A., Maciel, P.O., Oliveira, M.R., … Chagas, E.C. (2018). Lippia alba essential oil as anesthetic for tambaqui. Aquaculture, 495, 545-549. DOI: https://DOI.org/10.1016/j.aquaculture.2018.06.040.
Bersan, S.M.F., Galvão, L.C.C., Goes, V.F.F., Sartoratto, A., Figueira, G.M., Rehder, V.L.G., … Duarte, M.C.T. (2014). Action of essential oils from Brazilian native and exotic medicinal species on oral biofilms. BMC Complementary and Alternative Medicine, 14(1), 1-12. DOI: https://DOI.org/10.1186/1472-6882-14-451
BIOinTropic, Universidad EAFIT, & Silo. (2018). Estudio sobre bioeconomía como fuente de nuevas industrias basadas en el capital natural de Colombia. No. 1240667. Fase I: Anexo 4. Revisión de estudios previos y análisis de políticas de la Bioeconomía en Colombia. Universidad EAFIT, Colombia. Retrieved from https://www.dnp.gov.co/Crecimiento-Verde/Documents/ejes-tematicos/Bioeconomia/informe%201/ANX4.%20An%C3%A1lisis%20estudios%20previos%20y%20%20pol%C3%ADticas%20relacionadas.pdf
Blanco, M.A., Colareda, G.A., Baren, C., Bandoni, A.L., Ringuelet, J., & Consolini, A.E. (2013). Antispasmodic effects and composition of the essential oils from two South American chemotypes of Lippia alba. Journal of Ethnopharmacology, 149(3), 803-809. DOI: https://DOI.org/10.1016/j.jep.2013.08.007.
Bouyahya, A., Guaouguaou, F.E., Dakka, N., & Bakri, Y. (2017). Pharmacological activities and medicinal properties of endemic Moroccan medicinal plant Origanum compactum (Benth) and their main compounds. Asian Pacific Journal of Tropical Disease, 7(10), 628-640. DOI: https://DOI.org/10.12980/apjtd.7.2017D7-31.
Caballero-Gallardo, K., Olivero-Verbel, J., & Stashenko, E.E. (2011). Repellent activity of essential oils and some of their individual constituents against Tribolium castaneum herbst. Journal of Agricultural and Food Chemistry, 59(5), 1690-1696. DOI: https://DOI.org/10.1021/jf103937p
Cárdenas, C., Toni, C., Martos-Sitcha, J.A., Cárdenas, S., Heras, V., Baldisserotto, B., … Mancera, J.M. (2016). Effects of clove oil, essential oil of Lippia alba and 2-phe anaesthesia on juvenile meagre, Argyrosomus regius (Asso, 1801). Journal of Applied Ichthyology, 32(4), 693-700. DOI: https://DOI.org/10.1111/jai.13048
Carvalho, P.M., Macêdo, C.A.F., Ribeiro, T.F., Silva, A.A., Silva, R.E.R., Morais, L.P., … Barbosa, R. (2018). Effect of the Lippia alba (Mill.) N.E. Brown essential oil and its main constituents, citral and limonene, on the tracheal smooth muscle of rats. Biotechnology Reports, 17, 31-34. DOI: https://DOI.org/10.1016/j.btre.2017.12.002
Castillo, R.M., Stashenko, E., & Duque, J.E. (2017). Insecticidal and Repellent Activity of Several Plant-Derived Essential Oils Against Aedes aegypti. Journal of the American Mosquito Control Association, 33(1), 25-35. DOI: https://DOI.org/10.2987/16-6585.1
Chagas, A.C.S., Oliveira, M.C.S., Giglioti, R., Santana, R.C.M., Bizzo, H.R., Gama, P.E., & Chaves, F.C.M. (2016). Efficacy of 11 Brazilian essential oils on lethality of the cattle tick Rhipicephalus (Boophilus) microplus. Ticks and Tick-Borne Diseases, 7(3), 427-432. DOI: https://DOI.org/10.1016/j.ttbdis.2016.01.001
Costa, D.C.M., Vermelho, A.B., Almeida, C.M., Dias, E.P.S., Cedrola, S.M.L., Arrigoni-Blank, M. F., … Alviano, D.S. (2014). Inhibitory effect of linalool-rich essential oil from Lippia alba on the peptidase and keratinase activities of dermatophytes. Journal of Enzyme Inhibition and Medicinal Chemistry, 29(1), 12-17. DOI: https://DOI.org/10.3109/14756366.2012.743537
Cunha, M.A., Barros, F.M.C., Garcia, L.O., Veeck, A.P.L., Heinzmann, B.M., Loro, V.L., … Baldisserotto, B. (2010). Essential oil of Lippia alba: A new anesthetic for silver catfish, Rhamdia quelen. Aquaculture, 306, 403-406. DOI: https://DOI.org/10.1016/j.aquaculture.2010.06.014
Cunha, M.A., Silva, B.F., Delunardo, F.A.C., Benovit, S.C., Gomes, L.C., Heinzmann, B.M., & Baldisserotto, B. (2011). Anesthetic induction and recovery of Hippocampus reidi exposed to the essential oil of Lippia alba. Neotropical Ichthyology, 9(3), 683-688. DOI: https://DOI.org/10.1590/S1679-62252011000300022
Célis, M. (2018). El último metaanálisis sobre antidepresivos: Nada nuevo bajo el sol. Clínica Contemporánea, 9(1), 1-5. DOI: https://DOI.org/10.5093/cc2018a7
Delgado, J., Sánchez, M.S., & Bonilla, C.R. (2016). Efecto del secado y la edad de las plantas en la composición de los aceites esenciales de Lippia alba (Mill.) N.E.Br. ex Britton & amp; P. Wilson y Lippia origanoides Kunth. Acta Agronómica, 65(2), 170-175. DOI: https://DOI.org/10.15446/acag.v65n2.47576
Duarte, M.C.T., Figueira, G.M., Sartoratto, A., Rehder, V.L., & Delarmelina, C. (2005). Anti-Candida Activity of Brazilian Medicinal plants. Journal of Ethnopharmacology, 97(2), 305-311. DOI: https://DOI.org/10.1016/j.jep.2004.11.016
Duarte, M.C.T., Leme, E.E., Delarmelina, C., Soares, A.A., Figueira, G.M., & Sartoratto, A. (2007). Activity of essential oils from Brazilian medicinal plants on Escherichia coli. Journal of Ethnopharmacology, 111(2), 197-201. DOI: https://DOI.org/10.1016/j.jep.2006.11.034
Durán, D.C., Monsalve, L.A., Martínez, J.R., & Stashenko, E.E. (2007). Estudio comparativo de la composición química de aceites esenciales de Lippia alba provenientes de diferentes regiones de Colombia, y efecto del tiempo de destilación sobre la composición del aceite. Scientia et Technica, 1(33), 435-438.
Escobar, P., Leal, S.M., Herrera, L.V., Martinez, J.R., & Stashenko, E. (2010). Chemical composition and antiprotozoal activities of Colombian Lippia spp essential oils and their major components. Memórias do Instituto Oswaldo Cruz, 105(2), 184-190. DOI: https://DOI.org/10.1590/S0074-02762010000200013
Fauth, S., Campos, A.R., Silveira, E.R., & Rao, V.S. (2002). Efeitos de óleos essenciais de plantas no tempo de sono induzido por cetamina em camundongos. Revista Brasileira de Farmacognosia, 12, 112-113. DOI: https://DOI.org/10.1590/S0102-695X2002000300052
García-Perdomo, H.A. (2015). Conceptos fundamentales de las revisiones sistemáticas/metaanálisis. Urología Colombiana, 24(1), 28-34. DOI: https://DOI.org/10.1016/j.uroco.2015.03.005
Glamočlija, J., Soković, M., Tešević, V., Linde, G.A., & Colauto, N.B. (2011). Chemical characterization of Lippia alba essential oil: an alternative to control green molds. Brazilian Journal of Microbiology, 42(4), 1537-1546. DOI: https://DOI.org/10.1590/S1517-838220110004000041
Gomide, M., Lemos, F., Lopes, M., Alves, T., Viccini, L., & Coelho, C. (2013). The effect of the essential oils from five different Lippia species on the viability of tumor cell lines. Revista Brasileira de Farmacognosia, 23(2013), 895-902. DOI: https://DOI.org/10.1590/S0102-695X2013000600006
Grand View Research. (2018). Market Research Report (Data base). Retrieved from https://bit.ly/2S1bL8T
Hatano, V.Y., Torricelli, A.S., Giassi, A.C.C., Coslope, L.A., & Viana, M.B. (2012). Anxiolytic effects of repeated treatment with an essential oil from Lippia alba and (R)-(-)-carvone in the elevated T-maze. Brazilian Journal of Medical and Biological Research, 45(3), 238-243. DOI: https://DOI.org/10.1590/S0100-879X2012007500021
Hohlenwerger, J.C., Baldisserotto, B., Couto, R.D., Heinzmann, B.M., Silva, D.T., Caron, B.O., … Copatti, C. E. (2017). Essential oil of Lippia alba in the transport of Nile tilapia | Óleo essencial de Lippia alba no transporte de tilápia-do-Nilo. Ciencia Rural, 47(3), 1-4. DOI: https://DOI.org/10.1590/0103-8478cr20160040
Instituto Colombiano de Normas Técnicas y Certificación (ICONTEC). (2011). Guía sobre pruebas de estabilidad, cosméticos y productos de higiene doméstica (Guía técnica colombiana GTC 215). Colombia: ICONTEC. Retrieved from https://tienda.icontec.org/wp-content/uploads/pdfs/GTC215.pdf
Instituto Nacional de Vigilancia de Medicamentos y Alimentos (INVIMA). Por el cual se reglamenta parcialmente el Régimen de Registros y Licencias, el Control de Calidad, así como el Régimen de Vigilancia Sanitaria de Medicamentos, Cosméticos, Preparaciones Farmacéuticas a base de Recursos Naturales, Productos de Aseo, Higiene y Limpieza y otros productos de uso doméstico y se dictan otras disposiciones sobre la materia. (Decreto 677 de 1995). Colombia, INVIMA Retrieved from https://www.invima.gov.co/documents/20143/453029/decreto_677_1995.pdf
Instituto Nacional de Vigilancia de Medicamentos y Alimentos (INVIMA). (2018). Listado de plantas medicinales aceptadas con fines terapéuticos. Colombia: INVIMA Retrieved from https://bit.ly/2HmGxb0
Juiz, P.J.L., Lucchese, A.M., Gambari, R., Piva, R., Penolazzi, L., Ciano, M., … Avila-Campos, M. J. (2015). Essential oils and isolated compounds from Lippia alba leaves and flowers: Antimicrobial activity and osteoclast apoptosis. International Journal of Molecular Medicine, 35(1), 211-217. DOI: https://DOI.org/10.3892/ijmm.2014.1995
Junior, G.B., Abreu, M.S., Rosa, J.G.S., Pinheiro, C.G., Heinzmann, B.M., Caron, B.O., … Barcellos, L.J.G. (2018). Lippia alba and Aloysia triphylla essential oils are anxiolytic without inducing aversiveness in fish. Aquaculture, 482(2018), 49-56. DOI: https://DOI.org/10.1016/j.aquaculture.2017.09.023
Lima, A.S., Carvalho, J.F., Peixoto, M.G., Blank, A.F., Borges, L.M.F.F., & Junior, L.M. (2016). Assessment of the repellent effect of Lippia alba essential oil and major monoterpenes on the cattle tick Rhipicephalus microplus. Medical and Veterinary Entomology, 30(1), 73-77. DOI: https://DOI.org/10.1111/mve.12140
Linde, G.A., Colauto, N.B., Albertó, E., & Gazim, Z.C. (2016). Quimiotipos, Extracción, Composición y Aplicaciones del Aceite Esencial de Lippia alba. Revista Brasileira de Plantas Medicinais, 18(1), 191-200. DOI: https://DOI.org/10.1590/1983-084X/15_037
López, M.A., Stashenko, E.E., & Fuentes, J.L. (2011). Chemical composition and antigenotoxic properties of Lippia alba essential oils. Genetics and Molecular Biology, 34(3), 479-488. DOI: https://DOI.org/10.1590/S1415-47572011005000030
Machado, T.F., Nogueira, N.A., Pereira, R.C.A., Sousa, C.T., & Batista, V.C. (2014). The antimicrobial efficacy of Lippia alba essential oil and its interaction with food ingredients. Brazilian Journal of Microbiology, 45(2), 699-705. DOI: https://DOI.org/10.1590/S1517-83822014000200045
Majolo, C., Rocha, S.I.B., Chagas, E.C., Chaves, F.C.M., & Bizzo, H.R. (2017). Chemical composition of Lippia spp. essential oil and antimicrobial activity against Aeromonas hydrophila. Aquaculture Research, 48(5), 1-8. DOI: https://DOI.org/10.1111/are.13073
Maynard, L.G., Santos, K.C., Cunha, P.S., Barreto, A.S., Peixoto, M.G., Arrigoni-Blank, F., … Santos. M.R. (2011). Chemical composition and vasorelaxant effect induced by the essential oil of Lippia alba (Mill.) N.E. Brown. (Verbenaceae) in rat mesenteric artery. Indian Journal of Pharmacology, 43(6), 694-698. DOI: https://DOI.org/10.4103/0253-7613.89828
Mena-Rodríguez, E., Ortega-Cuadros, M., Merini, L., Melo-Ríos, A.E., & Tofiño-Rivera, A.P. (2018). Efecto de agroinsumos y aceites esenciales en el suelo de hortalizas en el Caribe colombiano. Corpoica Ciencia y Tecnología Agropecuaria, 19(1), 103-124. DOI: https://DOI.org/10.21930/rcta.vol19_num1_art:535
Meneses, R., Ocazionez, R., Martínez, J., & Stashenko, E. (2009). Inhibitory effect of essential oils obtained from plants grown in Colombia on yellow fever virus replication in vitro. Annals of Clinical Microbiology and Antimicrobials, 8(8), 1-6. DOI: https://DOI.org/10.1186/1476-0711-8-8
Mesa-Arango, A.C., Montiel-Ramos, J., Zapata, B., Durán, C., Betancur-Galvis, L., & Stashenko, E. (2009). Citral and carvone chemotypes from the essential oils of Colombian Lippia alba (Mill.) N.E. Brown: composition, cytotoxicity and antifungal activity. Memorias Do Instituto Oswaldo Cruz, 104(6), 878-884. DOI: https://DOI.org/10.1590/S0074-02762009000600010
Mesa-Arango, A.C., Betancur-Galvis, L., Montiel, J., Bueno, J.G., Baena, A., Durán, D.C., … Stashenko, E.E. (2010). Antifungal activity and chemical composition of the essential oils of Lippia alba (miller) N.E Brown grown in different regions of Colombia. Journal of Essential Oil Research, 22(6), 568-574. DOI: https://DOI.org/10.1080/10412905.2010.9700402
Ministerio de Salud y Protección Social (MinSalud). (2003). Por el cual se modifica el artículo 13 del Decreto 677 de 1995 y se dictan otras disposiciones (Decreto 2510 de 2003). MinSalud: Colombia. Retrieved from https://www.icbf.gov.co/cargues/avance/docs/decreto_2510_2003.htm
Ministerio de Salud y Protección Social (MinSalud). (2008). Vademécum Colombiano de Plantas Medicinales. Colombia: MinSalud. Retrieved from https://bit.ly/2UGvNXD
Moreira, F.J.C., Santos, C.D.G., & Innecco, R. (2009). Hatching and mortality of second-stage juveniles of Meloidogyne incognita race 2 in essential plant oils. Revista Ciencia Agronomica, 40(3), 441-448.
Moreno, É.M., Leal, S.M., Stashenko, E.E., & García, L.T. (2018). Induction of programmed cell death in Trypanosoma cruzi by Lippia alba essential oils and their major and synergistic terpenes (citral, limonene and caryophyllene oxide). BMC Complementary and Alternative Medicine, 18(1), 225. DOI: https://DOI.org/10.1186/s12906-018-2293-7
Muñoz, J.A., Staschenko, E., & Ocampo, C.B. (2014). Actividad insecticida de aceites esenciales de plantas nativas contra Aedes aegypti (Diptera: Culicidae). Revista Colombiana de Entomología, 40(2), 198-202. DOI: https://DOI.org/ISSN 0120-0488
Neira, L.F., Mantilla, J.C., Stashenko, E., & Escobar, P. (2018). Toxicidad, genotoxicidad y actividad anti-Leishmania de aceites esenciales obtenidos de cuatro (4) quimiotipos del género Lippia. Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas, 17(1), 68-83.
Ocazionez, R.E., Meneses, R., Torres, F.Á., & Stashenko, E. (2010). Virucidal activity of Colombian Lippia essential oils on dengue virus replication in vitro. Memorias Do Instituto Oswaldo Cruz, 105(3), 304-309. DOI: https://DOI.org/10.1590/S0074-02762010000300010
Olivero-Verbel, J., Güette-Fernandez, J., & Stashenko, E. (2009). Acute toxicity against Artemia franciscana of essential oils isolated from plants of the genus Lippia and Piper collected in Colombia. Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas, 8(5), 419-427.
Olivero-Verbel, J., González-Cervera, T., Güette-Fernandez, J., Jaramillo-Colorado, B., & Stashenko, E. (2010). Chemical composition and antioxidant activity of essential oils isolated from Colombian plants. Brazilian Journal of Pharmacognosy, 20(4), 568-574. DOI: https://DOI.org/10.1590/S0102-695X2010000400016
Olivero-Verbel, J., Guerrero-Castilla, A., & Stashenko, E. (2010). Toxicity of the essential oil of the cytral chemotype of Lippia alba (Mill.) N. E. Brown. Acta Toxicológica Argentina, 18(1), 21-27.
Ortega-Cuadros, M., Tofiño-Rivera, A.P., Merini, L.J., & Martinez-Pabón, M.C. (2018). Antimicrobial activity of Cymbopogon citratus (Poaceae) essential oil on Streptococcus mutans biofilm and cytotoxic effect on keratinocytes and fibroblasts. Revista de Biología Tropical, 66(4), 1519-1529. DOI: https://DOI.org/10.15517/rbt.v66i4.33140
Ortega-Cuadros, M. & Tofiño-Rivera, A.P. (2019). Revisión exploratoria de la actividad antibacteriana y antifúngica de Lippia alba (Mill.) N. E. Br (pronto alivio). Revista Cubana de Plantas Medicinales, 24(1), 1-14.
Palacio-López, K., & Rodríguez-López, N. (2008). Plasticidad fenotípica en Lippia alba (Verbenaceae) en respuesta a la disponibilidad hídrica en dos ambientes lumínicos. Acta Biológica Colombiana, 13(1), 187-198.
Parodi, T.V., Cunha, M.A., Heldwein, C.G., Souza, D.M., Martins, A.C., Garcia, L., … Baldisserotto, B. (2012). The anesthetic efficacy of eugenol and the essential oils of Lippia alba and Aloysia triphylla in post-larvae and sub-adults of Litopenaeus vannamei (Crustacea, Penaeidae). Comparative Biochemistry and Physiology, 155(3), 462-468. DOI: https://DOI.org/10.1016/j.cbpc.2011.12.003
Peixoto, M.G., Bacci, L., Fitzgerald Blank, A., Araújo, A.P.A., Alves, P.B., Silva, J.H.S., … Arrigoni-Blank, M. (2015a). Toxicity and repellency of essential oils of Lippia alba chemotypes and their major monoterpenes against stored grain insects. Industrial Crops and Products, 71(2015), 31-36. DOI: https://DOI.org/10.1016/j.indcrop.2015.03.084
Peixoto, M.G., Costa-Júnior, L.M., Blank, A.F., Lima, A., Menezes, T.S.A., Santos, D., … Arrigoni-Blank, M. (2015b). Acaricidal activity of essential oils from Lippia alba genotypes and its major components carvone, limonene, and citral against Rhipicephalus microplus. Veterinary Parasitology, 210, 118-122. DOI: https://DOI.org/10.1016/j.vetpar.2015.03.010
Pino, J.A., Ortega, L.A., Rosado, A. Rodríguez, M., & Baluja, R. (1996). Composición y propiedades antibacterianas del aceite esencial de Lippia alba (Mill.) N.E. Brown. Revista Cubana de Farmacia, 30(1), 29-35.
Plantlife International. (2004). Herbal harvests with a future. Towards sustainable sources for medicinal plants. Retrieved from https://goo.gl/N66iRp
Porfírio, E.M., Melo, H.M., Pereira, A.M.G., Cavalcante, T.T.A., Gomes, G.A., Carvalho, M.G., … Júnior, F.E.A.C. (2017). In Vitro Antibacterial and Antibiofilm Activity of Lippia alba Essential Oil, Citral, and Carvone against Staphylococcus aureus. Scientific World Journal, 2017, 1-7. DOI: https://DOI.org/10.1155/2017/4962707
Ramírez, L., & Castaño, D. (2009). Metodologías para evaluar in vitro la actividad antibacteriana de compuestos de origen vegetal. Scientia et Technica, 15(42), 263-268.
Ríos, N., Stashenko, E.E., & Duque, J.E. (2017). Evaluation of the insecticidal activity of essential oils and their mixtures against Aedes aegypti (Diptera: Culicidae). Revista Brasileira de Entomologia, 61(4), 307-311. DOI: https://DOI.org/10.1016/j.rbe.2017.08.005
Rodrigues-Soares, J.P., Jesus, G.F.A., Gonçalves, E.L.T., Moraes, K.N., Chagas, E.C., Chaves, F. C.M., … Martins, M.L. (2018). Induced aerocystitis and hemato-immunological parameters in nile tilapia fed supplemented diet with essential oil of Lippia alba. Brazilian Journal of Veterinary Research and Animal Science, 55(1), 1-12. DOI: https://DOI.org/10.11606/issn.1678-4456.bjvras.2018.136717
Salbego, J., Becker, A., Gonçalves, J., Menezes, C., Heldwein, C., Spanevello, R., … Baldisserotto, B. (2014). The essential oil from Lippia alba induces biochemical stress in the silver catfish (Rhamdia quelen) after transportation. Neotropical Ichthyology, 12(4), 811-818. DOI: https://DOI.org/10.1590/1982-0224-20130178
Salbego, J., Maia, J.L., Toni, C., Rodrigues, A.S.S., Sousa, E.M.O., Silva, L.V.F., … Baldisserotto, B. (2017a). Anesthesia and sedation of map treefrog (Hypsiboas geographicus) tadpoles with essential oils. Ciência Rural, 47(11), 1-6.
Salbego, J, Toni, C., Becker, A.G., Zeppenfeld, C.C., Menezes, C.C., Loro, V.L., … Baldisserotto, B. (2017b). Biochemical parameters of silver catfish (Rhamdia quelen) after transport with eugenol or essential oil of Lippia alba added to the water. Brazilian Journal of Biology, 77(4), 696-702. https://DOI.org/10.1590/1519-6984.16515
Santos, N., Pascon, R., Vallim, M., Figueiredo, C., Soares, M., Lago, J.H., & Sartorelli, P. (2016a). Cytotoxic and Antimicrobial Constituents from the Essential Oil of Lippia alba (Verbenaceae). Medicines, 3(3), 2-9. DOI: https://DOI.org/10.3390/medicines3030022
Santos, I.G., Scher, R., Rott, M.B., Menezes, L.R., Costa, E.V., Cavalcanti, S.C., … Dolabella, S. (2016b). Amebicidal activity of the essential oils of Lippia spp. (Verbenaceae) against Acanthamoeba polyphaga trophozoites. Parasitology Research, 115(2), 535-540. DOI: https://DOI.org/10.1007/s00436-015-4769-4
Sena, A.C., Teixeira, R.R., Ferreira, E.L., Heinzmann, B.M., Baldisserotto, B., Caron, B.O., … Copatti, C.E. (2016). Essential oil from Lippia alba has anaesthetic activity and is effective in reducing handling and transport stress in tambacu (Piaractus mesopotamicus × Colossoma macropomum). Aquaculture, 465(2016), 374-379. DOI: https://DOI.org/10.1016/j.aquaculture.2016.09.033
Sepúlveda-Arias, J.C., Veloza, L.A., Escobar, L.M., Orozco, L.M., & Lopera, I.A. (2013). Anti-inflammatory effects of the main constituents and epoxides derived from the essential oils obtained from Tagetes lucida, Cymbopogon citratus, Lippia alba and Eucalyptus citriodora. Journal of Essential Oil Research, 25(3), 186-193. DOI: https://DOI.org/10.1080/10412905.2012.751556
Shukla, R., Kumar, A., Singh, P., & Dubey, N. K. (2009). Efficacy of Lippia alba (Mill.) N.E. Brown essential oil and its monoterpene aldehyde constituents against fungi isolated from some edible legume seeds and aflatoxin B1 production. International Journal of Food Microbiology, 135(2), 165-170. DOI: https://DOI.org/10.1016/j.ijfoodmicro.2009.08.002
Simões, L.N., Medeiros, L.C.C., Heinzmann, B.M., Loro, V.L., Gomes, L.C., Silva, D.T., … Baldisserotto, B. (2017). Essential oil of Lippia alba as a sedative and anesthetic for the sea urchin Echinometra lucunter (Linnaeus, 1758). Marine and Freshwater Behaviour and Physiology, 50(3), 205-217. DOI: https://DOI.org/10.1080/10236244.2017.1362317
Silva, R.E.R., Morais, L.P., Silva, A.A., Bastos, C.M.S., Pereira-Gonçalves, Á., Kerntopf, M.R., … Barbosa, R. (2018). Vasorelaxant effect of the Lippia alba essential oil and its major constituent, citral, on the contractility of isolated rat aorta. Biomedicine and Pharmacotherapy, 108, 792-798. DOI: https://DOI.org/10.1016/j.biopha.2018.09.073
Soares, B.V., Neves, L.R., Oliveira, M.S.B., Chaves, F.C.M., Dias, M.K.R., Chagas, E.C., & Tavares-Dias, M. (2016). Antiparasitic activity of the essential oil of Lippia alba on ectoparasites of Colossoma macropomum (tambaqui) and its physiological and histopathological effects. Aquaculture, 452(2016), 107-114. DOI: https://DOI.org/10.1016/j.aquaculture.2015.10.029
Sousa, D.G., Sousa, S.D.G., Silva, R.E.R., Silva-Alves, K.S., Ferreira-da-Silva, F.W., Kerntopf, M.R., … Barbosa, R. (2015). Essential oil of Lippia alba and its main constituent citral block the excitability of rat sciatic nerves. Brazilian Journal of Medical and Biological Research, 48(8), 697-702. DOI: https://DOI.org/10.1590/1414-431X20154710
Souza, P.M., Goulart, F.R.G., Marques, J.M., Bizzo, H.R., Blank, A.F., Groposo, C., … Seldin, L. (2017a). Growth Inhibition of Sulfate-Reducing Bacteria in Produced Water from the Petroleum Industry Using Essential Oils. Molecules, 22(4), 1-10. https://DOI.org/10.3390/molecules22040648
Souza, R.C., Costa, M.M., Baldisserotto, B., Heinzmann, B.M., Schmidt, D., Caron, B.O., & Copatti, C.E. (2017b). Antimicrobial and synergistic activity of essential oils of Aloysia triphylla and Lippia alba against Aeromonas spp. Microbial Pathogenesis, 113(2017), 29-33. https://DOI.org/10.1016/j.micpath.2017.10.013
Souza, C., Lima, T., Baldissera, M., Geihs, M., Maciel, F., Nery, L., … Baldisserotto, B. (2018). Nanoencapsulated Melaleuca alternifolia essential oil exerts anesthetic effects in the brachyuran crab using Neohelice granulate. Anais Da Academia Brasileira de Ciencias, 90(3), 2855-2864. DOI: https://DOI.org/10.1590/0001-3765201820170930
Stashenko, E.E., Jaramillo, B.E., & Martı́nez, J.R. (2004). Comparison of different extraction methods for the analysis of volatile secondary metabolites of Lippia alba (Mill.) N.E. Brown, grown in Colombia, and evaluation of its in vitro antioxidant activity. Journal of Chromatography A, 1025(1), 93-103. DOI: https://DOI.org/10.1016/j.chroma.2003.10.058
Sutili, F., Cunha, M., Ziech, R., Krewer, C., Zeppenfeld, C., Heldwein, C., … Baldisserotto, B. (2015). Lippia alba essential oil promotes survival of silver catfish (Rhamdia quelen) infected with Aeromonas sp. Anais Da Academia Brasileira de Ciências, 87(1), 95-100. DOI: https://DOI.org/10.1590/0001-3765201520130442
Tangarife-Castaño, V., Roa-Linares, V., Betancur-Galvis, L.A., Durán García, D.C., Stashenko, E., & Mesa-Arango, A.C. (2012). Antifungal activity of Verbenaceae and Labiatae families essential oils. Pharmacologyonline, 1, 133-145.
Tofiño-Rivera, A.P., Ortega-Cuadros, M., Galvis-Pareja, D., Jimenez-Rios, H., Merini, L.J., & Martinez-Pabón, M.C. (2016). Effect of Lippia alba and Cymbopogon citratus essential oils on biofilms of Streptococcus mutans and cytotoxicity in CHO cells. Journal of Ethnopharmacology, 194(2016), 749-754. DOI: https://DOI.org/10.1016/j.jep.2016.10.044
Tofiño-Rivera, A.P., Ortega-Cuadros, M., Melo-Ríos, A., & Mier-giraldo, H.J. (2017). Vigilancia tecnológica de plantas aromáticas: de la investigación a la consolidación de la agrocadena colombiana. Corpoica Ciencia y Tecnología Agropecuaria, 18(2), 1-25. DOI: https://DOI.org/10.21930/rcta.vol18_num2_art:636
Toni, C., Becker, A.G., Simões, L.N., Pinheiro, C.G., Silva, L., Heinzmann, B.M., … Baldisserotto, B. (2014). Fish anesthesia: Effects of the essential oils of Hesperozygis ringens and Lippia alba on the biochemistry and physiology of silver catfish (Rhamdia quelen). Fish Physiology and Biochemistry, 40(3), 701-714. DOI: https://DOI.org/10.1007/s10695-013-9877-4
Toni, C., Martos-Sitcha, J.A., Baldisserotto, B., Heinzmann, B.M., Silva, L., Martínez-Rodríguez, G., & Mancera, J.M. (2015). Sedative effect of 2-phenoxyethanol and essential oil of Lippia alba on stress response in gilthead sea bream (Sparus aurata). Research in Veterinary Science, 103, 20-27. DOI: https://DOI.org/10.1016/j.rvsc.2015.09.006
Valero, M.A., Vidal, A., Burgos, R., Calvo, F.L., Martínez, C., Luengo, L.M., & Cuerda, C. (2011). Meta-análisis del papel del licopeno en la diabetes mellitus tipo 2. Nutrición Hospitalaria, 26(6), 1236-1241. DOI: https://DOI.org/10.3305/nh.2011.26.6.5406
Veeck, A. P., Klein, B., Ferreira, L., Becker, A., Heldwein, C., Heinzmann, B., … Emanuelli, T. (2013). Lipid stability during the frozen storage of fillets from silver catfish exposed in vivo to the essential oil of Lippia alba (Mill.) NE Brown. Journal of the Science of Food and Agriculture, 93(4), 955-960. DOI: https://DOI.org/10.1002/jsfa.5833
Veeck, A.P.L., Daniel, A.P., Klein, B., Quatrin, A., Rezer, A.P.S., Milani, L.G., … Emanuelli, T. (2018). Chemical, microbiological, and sensory parameters during the refrigerated storage of silver catfish (Rhamdia quelen) exposed in vivo to the essential oil of Lippia alba. Journal of Food Science and Technology, 55(4), 1416-1425. DOI: https://DOI.org/10.1007/s13197-018-3056-7
Veit, J., Piccolo, J., Scherer, A., Machado, I., Peres, M., Schwerz, J., … Emanuelli, T. (2017). Stability of frozen fillets from silver catfish anesthetized with essential oil of Lippia alba prior to electrical stunning or hypothermia. Journal of Food Processing and Preservation, 41(5), 1-10. DOI: https://DOI.org/10.1111/jfpp.13167
Vera, A.P., Olivero, J., Jaramillo, B., & Stashenko, E. (2010). Efecto protector del aceite esencial de Lippia alba (Mill.) N.E.: Brown sobre la toxicidad del mercurocromo en raíces de Allium cepa L. Revista Cubana de Plantas Medicinales, 15(1), 27-37.
Vera, S.S., Zambrano, D.F., Méndez-Sanchez, S.C., Rodríguez-Sanabria, F., Stashenko, E.E., & Luna, J.E. (2014). Essential oils with insecticidal activity against larvae of Aedes aegypti (Diptera: Culicidae). Parasitology Research, 113(7), 2647-2654. DOI: https://DOI.org/10.1007/s00436-014-3917-6
Viana, G.S., Vale, T.G., Silva, C.M.M., & Matos, F.J. (2000). Anticonvulsant activity of essential oils and active principles from chemotypes of Lippia alba (Mill.) N.E. Brown. Biological and Pharmaceutical Bulletin, 23(11), 1314-1317. DOI: https://DOI.org/10.1248/cpb.37.3229
World Health Organization (WHO). (2004). New WHO guidelines to promote proper use of alternative medicines. Geneva: World Health Organization. Retrieved from https://www.who.int/mediacentre/news/releases/2004/pr44/en
Zambrano, É.L., Buitrago, L.Á., Durán, L., Sánchez, M.S., & Bonilla, C.R. (2013). Efecto de la fertilización nitrogenada en el rendimiento y la composición de los aceites esenciales de especies y accesiones de Lippia. Acta Agronómica, 62(2), 129-135.
Zapata, B., Betancur-Galvis, L., Duran, C., & Stashenko, E. (2013). Cytotoxic activity of Asteraceae and Verbenaceae family essential oils. Journal of Essential Oil Research, 26(1), 50-57. DOI: https://DOI.org/10.1080/10412905.2013.820674
Comentarios
Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
Derechos de autor 2020 Mailen Ortega Cuadros, Emma E Acosta de Guevara, Ailen D Molina Castillo, Clara Gutiérrez Castañeda, Glorismar Castro Amarís, Adriana P Tofiño-Rivera