Revista de Biología Tropical ISSN Impreso: 0034-7744 ISSN electrónico: 2215-2075

OAI: https://revistas.ucr.ac.cr/index.php/rbt/oai
Time to say good bye to the Krebs Cycle
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Cómo citar

Monge-Nájera, J. (2022). Time to say good bye to the Krebs Cycle. Revista De Biología Tropical, (9). Recuperado a partir de https://revistas.ucr.ac.cr/index.php/rbt/article/view/51668

Resumen

For decades, millions of students have memorized the Krebs Cycle for tests, and forgotten it immediately afterwards. Here I propose a new approach, based on understanding rather than memorizing, and on teaching about the spectacular accomplishment of the men and women who solved the riddle; about the human solidarity that allowed Krebs to flee the Nazis; and about how newer study of the cycle helps us understand and treat cancer, sleeping sickness and other ailments.

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Citas

Krebs, H. (1982). Reminiscences and Reflections. Oxford, Oxford University Press.

van Weelden, S. W., van Hellemond, J. J., Opperdoes, F. R., & Tielens, A. G. (2005). New functions for parts of the Krebs cycle in procyclic Trypanosoma brucei, a cycle not operating as a cycle. Journal of Biological Chemistry, 280(13), 12451-12460.

Sajnani, K., Islam, F., Smith, R. A., Gopalan, V., & Lam, A. K. Y. (2017). Genetic alterations in Krebs cycle and its impact on cancer pathogenesis. Biochimie, 135, 164-172.

Magnusson, I., Schumann, W. C., Bartsch, G. E., Chandramouli, V., Kumaran, K., Wahren, J., & Landau, B. R. (1991). Noninvasive tracing of Krebs cycle metabolism in liver. Journal of Biological Chemistry, 266(11), 6975-6984.

Ryan, D. G., & O'Neill, L. A. (2020). Krebs cycle reborn in macrophage immunometabolism. Annual review of immunology, 38, 289-313.

Ritson, D. J. (2021). A cyanosulfidic origin of the Krebs cycle. Science Advances, 7(33), eabh3981.

Buchanan, B. B., & Arnon, D. I. (1990). A reverse KREBS cycle in photosynthesis: consensus at last. Photosynthesis Research, 24, 47-53.

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