Población y Salud en Mesoamérica ISSN electrónico: 1659-0201

OAI: https://revistas.ucr.ac.cr/index.php/psm/oai
Frequency of mutations in the BRCA genes in women with a familial aggregation of mammary gland/ovarian cancer
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Keywords

breast neoplasms
ovarian neoplasms
BRCA1 gene
BRCA2 gene
mutation
heredity
neoplasias de la mama
neoplasias ováricas
gen BRCA1
gen BRCA2
mutación
herencia

How to Cite

Benavides-Cerquera, J. D., Bohórquez-Lozano, M. E., Prada-Quiroga, C. F., Carvajal-Carmona, L., & Echeverry de Polanco, M. M. (2016). Frequency of mutations in the BRCA genes in women with a familial aggregation of mammary gland/ovarian cancer. Población Y Salud En Mesoamérica, 14(1). https://doi.org/10.15517/psm.v14i1.25016

Abstract

Objective: Collect evidence about the frequency variation of BRCA1 and BRCA2 mutations and family history in patients with mammary gland cancer (MGC) and ovarian cancer (OC) from different geographical backgrounds. Method: This paper presents a systematic review using the PRISMA protocol parameters to estimate the prevalence of mutations in BRCA 1/2 genes in patients with MGC and OC, the incidence of family history and the observed prevalence in sporadic cases with this type of cancer. Results: Heterogeneity is observed in the frequency of mutations of these genes in studies of family history ranging between 0.0 and 0.48 in patients and families with MGC and OC similar to those previously reported. Discussion: This wide range of frequency is due to the origin of the studied population, the number of individuals analyzed and genotyping methodology used. The review reveals that the family MGC and OC is twice as common compared with cases of the same disease of a sporadic origin. Conclusions: This type of molecular studies allows other people who have family history of MGC and OC to perform early analysis and tests to prevent the future development of this neoplasia.
https://doi.org/10.15517/psm.v14i1.25016
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References

Las referencias marcadas con asterisco indican estudios comprendidos en la revisión sistemática.

Abugattas, J., Llacuachaqui, M., Allende, Y. S., Velásquez, A. A., Velarde, R., Cotrina, J., & Narod, S. A. (2015). Prevalence of BRCA1 and BRCA2 mutations in unselected breast cancer patients from Peru. Clin Genet, 88(4), 371-375. doi: 10.1111/cge.12505

Akbari, M. R., Donenberg, T., Lunn, J., Curling, D., Turnquest, T., Krill-Jackson, E., & Hurley, J. (2014). The spectrum of BRCA1 and BRCA2 mutations in breast cancer patients in the Bahamas. Clin Genet, 85(1), 64-67. doi: 10.1111/cge.12132

Anglian Breast Cancer Study Group. (2000). Prevalence and penetrance of BRCA1 and BRCA2 mutations in a population-based series of breast cancer cases. Anglian Breast Cancer Study Group. Br J Cancer, 83(10), 1301-1308. doi: 10.1054/bjoc.2000.1407

Apostolou, P., & Fostira, F. (2013). Hereditary breast cancer: the era of new susceptibility genes. Biomed Res Int, 1-12. doi: 10.1155/2013/747318

*Ashton-Prolla, P., & Vargas, F. R. (2014). Prevalence and impact of founder mutations in hereditary breast cancer in Latin America. Genet Mol Biol, 37(1 Suppl), 234-240.

Beller, U., Halle, D., Catane, R., Kaufman, B., Hornreich, G., & Levy-Lahad, E. (1997). High frequency of BRCA1 and BRCA2 germline mutations in Ashkenazi Jewish ovarian cancer patients, regardless of family history. Gynecol Oncol, 67(2), 123-126. doi: 10.1006/gyno.1997.4844

Berzina, D., Nakazawa-Miklasevica, M., Zestkova, J., Aksenoka, K., Irmejs, A., Gardovskis, A., & Miklasevics, E. (2013). BRCA1/2 mutation screening in high-risk breast/ovarian cancer families and sporadic cancer patient surveilling for hidden high-risk families. BMC Med Genet, 14(61), 1-5. doi: 10.1186/1471-2350-14-61

Blay, P., Santamaria, I., Pitiot, A. S., Luque, M., Alvarado, M. G., Lastra, A., & Balbin, M. (2013). Mutational analysis of BRCA1 and BRCA2 in hereditary breast and ovarian cancer families from Asturias (Northern Spain). BMC Cancer, 13(243), 1-10. doi: 10.1186/1471-2407-13-243

Brankovic-Magic, M., Dobricic, J., & Krivokuca, A. (2012). Genetics of breast cancer: contribution of BRCA1/2 genes alterations to hereditary predisposition. Vojnosanit Pregl, 69(8), 700-706.

Calderon-Garciduenas, A. L., Ruiz-Flores, P., Cerda-Flores, R. M., & Barrera-Saldana, H. A. (2005). Clinical follow up of mexican women with early onset of breast cancer and mutations in the BRCA1 and BRCA2 genes. Salud Publica Mex, 47(2), 110-115.

Caleca, L., Putignano, A. L., Colombo, M., Congregati, C., Sarkar, M., Magliery, T. J., & Radice, P. (2014). Characterization of an Italian founder mutation in the RING-finger domain of BRCA1. PLoS One, 9(2), 1-9. doi: 10.1371/journal.pone.0086924

Cao, W., Wang, X., & Li, J. C. (2013). Hereditary breast cancer in the Han Chinese population. J Epidemiol, 23(2), 75-84.

Cornejo-Moreno, B. A., Uribe-Escamilla, D., & Salamanca-Gomez, F. (2014). Breast cancer genes: looking for BRACA's lost brother. Isr Med Assoc J, 16(12), 787-792.

Delgado, L., Fernandez, G., Grotiuz, G., Cataldi, S., González, A., Lluveras, N., & Muse, I. M. (2011). BRCA1 and BRCA2 germline mutations in Uruguayan breast and breast-ovarian cancer families. Identification of novel mutations and unclassified variants. Breast Cancer Res Treat, 128(1), 211-218. doi: 10.1007/s10549-010-1320-2

Dillenburg, C. V., Bandeira, I. C., Tubino, T. V., Rossato, L. G., Dias, E. S., Bittelbrunn, A. C., & Leistner-Segal, S. (2012). Prevalence of 185delAG and 5382insC mutations in BRCA1, and 6174delT in BRCA2 in women of Ashkenazi Jewish origin in southern Brazil. Genet Mol Biol, 35(3), 599-602. doi: 10.1590/s1415-47572012000400009

Donenberg, T., Lunn, J., Curling, D., Turnquest, T., Krill-Jackson, E., Royer, R., & Hurley, J. (2011). A high prevalence of BRCA1 mutations among breast cancer patients from the Bahamas. Breast Cancer Res Treat, 125(2), 591-596. doi: 10.1007/s10549-010-1156-9

*Dufloth, R. M., Carvalho, S., Heinrich, J. K., Shinzato, J. Y., Dos Santos, C. C., Zeferino, L. C., & Schmitt, F. (2005). Analysis of BRCA1 and BRCA2 mutations in Brazilian breast cancer patients with positive family history. Sao Paulo Med J, 123(4), 192-197. doi: /S1516-31802005000400007

*Dutil, J., Colon-Colon, J. L., Matta, J. L., Sutphen, R., & Echenique, M. (2012). Identification of the prevalent BRCA1 and BRCA2 mutations in the female population of Puerto Rico. Cancer Genet, 205(5), 242-248. doi: 10.1016/j.cancergen.2012.04.002

Dutil, J., Golubeva, V. A., Pacheco-Torres, A. L., Diaz-Zabala, H. J., Matta, J. L., & Monteiro, A. N. (2015). The spectrum of BRCA1 and BRCA2 alleles in Latin America and the Caribbean: a clinical perspective. Breast Cancer Res Treat, 154(3), 441-453. doi: 10.1007/s10549-015-3629-3

*Esteves, V. F., Thuler, L. C., Amendola, L. C., Koifman, R. J., Koifman, S., Frankel, P. P., & Vieira, R. J. (2009). Prevalence of BRCA1 and BRCA2 gene mutations in families with medium and high risk of breast and ovarian cancer in Brazil. Braz J Med Biol Res, 42(5), 453-457.

*Ewald, I. P., Izetti, P., Vargas, F. R., Moreira, M. A., Moreira, A. S., Moreira-Filho, C. A., & Ashton-Prolla, P. (2011). Prevalence of the BRCA1 founder mutation c.5266dupin Brazilian individuals at-risk for the hereditary breast and ovarian cancer syndrome. Hered Cancer Clin Pract, 9, 12. doi: 10.1186/1897-4287-9-12

Gallardo, M., Silva, A., Rubio, L., Álvarez, C., Torrealba, C., Salinas, M., & Carvallo, P. (2006). Incidence of BRCA1 and BRCA2 mutations in 54 Chilean families with breast/ovarian cancer, genotype-phenotype correlations. Breast Cancer Res Treat, 95(1), 81-87. doi: 10.1007/s10549-005-9047-1

Ghoussaini, M., Pharoah, P. D., & Easton, D. F. (2013). Inherited genetic susceptibility to breast cancer: the beginning of the end or the end of the beginning? Am J Pathol, 183(4), 1038-1051. doi: 10.1016/j.ajpath.2013.07.003

Gomes, M. C., Costa, M. M., Borojevic, R., Monteiro, A. N., Vieira, R., Koifman, S., & Narod, S. A. (2007). Prevalence of BRCA1 and BRCA2 mutations in breast cancer patients from Brazil. Breast Cancer Res Treat, 103(3), 349-353. doi: 10.1007/s10549-006-9378-6

Gómez, K. D. y Barreto, G. (2015). Barrido mutacional parcial del gen BRCA 1 en mujeres con cáncer de mama familiar (Tesis doctoral inédita). Universidad del Valle, Colombia. Recuperado de http://bibliotecadigital.univalle.edu.co/bitstream/10893/8547/1/CB-0510948.pdf

Gonzalez-Hormazabal, P., Gutierrez-Enriquez, S., Gaete, D., Reyes, J. M., Peralta, O., Waugh, E., & Jara, L. (2011). Spectrum of BRCA1/2 point mutations and genomic rearrangements in high-risk breast/ovarian cancer Chilean families. Breast Cancer Res Treat, 126(3), 705-716. doi: 10.1007/s10549-010-1170-y

Gutiérrez, G., Llacuachaqui, M., García‐Jiménez, L., Aguilar, M., Loáiciga, K., Ortiz, A., & Narod, S. (2012). BRCA1 and BRCA2 mutations among familial breast cancer patients from Costa Rica. Clin Genet, 82(5), 484-488.

Hamann, U., Liu, X., Lange, S., Ulmer, H. U., Benner, A., & Scott, R. J. (2002). Contribution of BRCA2 germline mutations to hereditary breast/ovarian cancer in Germany. J Med Genet, 39(3), 1-6.

Han, S. A., Kim, S. W., Kang, E., Park, S. K., Ahn, S. H., Lee, M. H., & Jung, S. H. (2013). The prevalence of BRCA mutations among familial breast cancer patients in Korea: results of the Korean Hereditary Breast Cancer study. Fam Cancer, 12(1), 75-81. doi: 10.1007/s10689-012-9578-7

*Hernández, J. E., Llacuachaqui, M., Palacio, G. V., Figueroa, J. D., Madrid, J., Lema, M., & Narod, S. A. (2014). Prevalence of BRCA1 and BRCA2 mutations in unselected breast cancer patients from Medellin, Colombia. Hered Cancer Clin Pract, 12(1), 11. doi: 10.1186/1897-4287-12-11

Hirasawa, A., Masuda, K., Akahane, T., Ueki, A., Yokota, M., Tsuruta, T., & Aoki, D. (2014). Family history and BRCA1/BRCA2 status among Japanese ovarian cancer patients and occult cancer in a BRCA1 mutant case. Jpn J Clin Oncol, 44(1), 49-56. doi: 10.1093/jjco/hyt171

International Agency for Research on Cancer & World Health Organization. (2014). GLOBOCAN: Estimated Cancer Incidence, Mortality, and Prevalence Worldwide in 2012: IARC. Recuperado de http://globocan.iarc.fr/Default.aspx

Jemal, A., Center, M. M., DeSantis, C., & Ward, E. M. (2010). Global patterns of cancer incidence and mortality rates and trends. Cancer Epidemiology Biomarkers & Prevention, 19(8), 1893-1907.

*John, E. M., Miron, A., Gong, G., Phipps, A. I., Felberg, A., Li, F. P., & Whittemore, A. S. (2007). Prevalence of pathogenic BRCA1 mutation carriers in 5 US racial/ethnic groups. Jama, 298(24), 2869-2876. doi: 10.1001/jama.298.24.2869

Kuchenbaecker, K. B., Ramus, S. J., Tyrer, J., Lee, A., Schen, H., Beesley, J., Lawreson, K., & Chenevix-Trench, G. (2015). Identification of six new susceptibility loci for invasive epithelial ovarian cancer. Nat Genet., 47(2), 164-171. doi: 10.1038/ng.3185

Kuusisto, K. M., Bebel, A., Vihinen, M., Schleutker, J., & Sallinen, S. L. (2011). Screening for BRCA1, BRCA2, CHEK2, PALB2, BRIP1, RAD50, and CDH1 mutations in high-risk Finnish BRCA1/2-founder mutation-negative breast and/or ovarian cancer individuals. Breast Cancer Res, 13(1), 1-13. doi: 10.1186/bcr2832

Kwong, A., Ng, E. K., Wong, C. L., Law, F. B., Au, T., Wong, H. N., & Ma, E. S. (2012). Identification of BRCA1/2 founder mutations in Southern Chinese breast cancer patients using gene sequencing and high resolution DNA melting analysis. PLoS One, 7(9), 1-10. doi: 10.1371/journal.pone.0043994

*Lara, K., Consigliere, N., Perez, J., & Porco, A. (2012). BRCA1 and BRCA2 mutations in breast cancer patients from Venezuela. Biol Res, 45(2), 117-130. doi: 10.4067/s0716-97602012000200003

Lynch, H. T., & Lynch, J. F. (1996). Breast cancer genetics: family history, heterogeneity, molecular genetic diagnosis, and genetic counselling. Curr Probl Cancer, 20(6), 329-365.

Lynch, H. T., Snyder, C., & Casey, M. J. (2013). Hereditary ovarian and breast cancer: what have we learned?. Ann Oncol, 24(8), 83-95. doi: 10.1093/annonc/mdt313

Mahfoudh, W., Bouaouina, N., Ahmed, S. B., Gabbouj, S., Shan, J., Mathew, R., & Chouchane, L. (2012). Hereditary breast cancer in Middle Eastern and North African (MENA) populations: identification of novel, recurrent and founder BRCA1 mutations in the Tunisian population. Mol Biol Rep, 39(2), 1037-1046. doi: 10.1007/s11033-011-0829-8

Malone, K. E., Daling, J. R., Doody, D. R., Hsu, L., Bernstein, L., Coates, R. J., & Ostrander, E. A. (2006). Prevalence and predictors of BRCA1 and BRCA2 mutations in a population-based study of breast cancer in white and black American women ages 35 to 64 years. Cancer Res, 66(16), 8297-8308. doi: 10.1158/0008-5472.can-06-0503

McKean-Cowdin, R., Spencer, H., Xia, L. Y., Pearce, C. L., Thomas, D. C., Stram, D. O., & Henderson, B. E. (2005). BRCA1 variants in a family study of African-American and Latina women. Hum Genet, 116(6), 497-506. doi: 10.1007/s00439-004-1240-5

Metcalfe, K., Lubinski, J., Lynch, H. T., Ghadirian, P., Foulkes, W. D., Kim-Sing, C., & Gronwald, J. (2010). Family history of cancer and cancer risks in women with BRCA1 or BRCA2 mutations. Journal of the National Cancer Institute, 102(24), 1874-8. doi: 10.1093/jnci/djq443

Minion, L. E., Dolinsky, J. S., Chase, D. M., Dunlop, C. L., Chao, E. C., & Monk, B. J. (2015). Hereditary predisposition to ovarian cancer, looking beyond BRCA1/BRCA2. Gynecol Oncol, 137(1), 86-92. doi: 10.1016/j.ygyno.2015.01.537

Molina-Montes, E., Perez-Nevot, B., Pollan, M., Sanchez-Cantalejo, E., Espin, J., & Sánchez, M. J. (2014). Cumulative risk of second primary contralateral breast cancer in BRCA1/BRCA2 mutation carriers with a first breast cancer: A systematic review and meta-analysis. Breast, 23(6), 721-742. doi: 10.1016/j.breast.2014.10.005

Narod, S. A., & Rodríguez, A. A. (2011). Genetic predisposition for breast cancer: BRCA1 and BRCA2 genes. Salud Publica Mex, 53(5), 420-429.

O'Donovan, P. J., & Livingston, D. M. (2010). BRCA1 and BRCA2: breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair. Carcinogenesis, 31(6), 961-967. doi: 10.1093/carcin/bgq069

*Ou, J., Wu, T., Sijmons, R., Ni, D., Xu, W., & Upur, H. (2013). Prevalence of BRCA1 and BRCA2 Germline Mutations in Breast Cancer Women of Multiple Ethnic Region in Northwest China. J Breast Cancer, 16(1), 50-54. doi: 10.4048/jbc.2013.16.1.50

Parkes, J., Hyde, C., Deeks, J. J., Milne, R., Pujol-Ribera, E., & Foz, G. (2001). Teaching critical appraisal skills in health care settings. Cochrane Database Syst Rev, 3(3). doi: 10.1002/14651858.CD001270

Paul, A., & Paul, S. (2014). The breast cancer susceptibility genes (BRCA) in breast and ovarian cancers. Front Biosci (Landmark Ed), 19, 605-618.

Peto, J., Collins, N., Barfoot, R., Seal, S., Warren, W., Rahman, N., & Stratton, M. R. (1999). Prevalence of BRCA1 and BRCA2 gene mutations in patients with early-onset breast cancer. J Natl Cancer Inst, 91(11), 943-949.

Privat, M., Aubel, C., Arnould, S., Communal, Y., Ferrara, M., & Bignon, Y. J. (2009). Breast cancer cell response to genistein is conditioned by BRCA1 mutations. Biochem Biophys Res Commun, 379(3), 785-789. doi: 10.1016/j.bbrc.2008.12.151

Rodríguez, A. O., Llacuachaqui, M., Pardo, G. G., Royer, R., Larson, G., Weitzel, J. N., & Narod, S. A. (2012). BRCA1 and BRCA2 mutations among ovarian cancer patients from Colombia. Gynecol Oncol, 124(2), 236-243. doi: 10.1016/j.ygyno.2011.10.027

Rodríguez, R. C., Esperon, A. A., Ropero, R., Rubio, M. C., Rodríguez, R., Ortiz, R. M., & Narod, S. A. (2008). Prevalence of BRCA1 and BRCA2 mutations in breast cancer patients from Cuba. Fam Cancer, 7(3), 275-279. doi: 10.1007/s10689-008-9187-7

Ruiz-Flores, P., Sinilnikova, O. M., Badzioch, M., Calderon-Garciduenas, A. L., Chopin, S., Fabrice, O., & Barrera-Saldana, H. A. (2002). BRCA1 and BRCA2 mutation analysis of early-onset and familial breast cancer cases in Mexico. Hum Mutat, 20(6), 474-475. doi: 10.1002/humu.9084

Saam, J., Moyes, K., Landon, M., Williams, K., Kaldate, R. R., Arnell, C., & Wenstrup, R. (2015). Hereditary cancer-associated mutations in women diagnosed with two primary cancers: an opportunity to identify hereditary cancer syndromes after the first cancer diagnosis. Oncology, 88(4), 226-233. doi: 10.1159/000368836

*Sanabria, M. C., Munioz, G., & Vargas, C. I. (2009). Mutations in the BRCA1 gene (185delAG and 5382insC) are not present in any of the 30 breast cancer patients analyzed from eastern Colombia. Biomedica, 29(1), 61-72.

Schlebusch, C. M., Dreyer, G., Sluiter, M. D., Yawitch, T. M., van den Berg, H. J., & van Rensburg, E. J. (2010). Cancer prevalence in 129 breast-ovarian cancer families tested for BRCA1 and BRCA2 mutations. S Afr Med J, 100(2), 113-117.

Seong, M. W., Cho, S. I., Kim, K. H., Chung, I. Y., Kang, E., Lee, J. W., & Kim, S. W. (2014). A multi-institutional study of the prevalence of BRCA1 and BRCA2 large genomic rearrangements in familial breast cancer patients. BMC Cancer, 14, 1-6. doi: 10.1186/1471-2407-14-645

*Silva, F. C., Lisboa, B. C., Figueiredo, M. C., Torrezan, G. T., Santos, E. M., Krepischi, A. C., & Carraro, D. M. (2014). Hereditary breast and ovarian cancer: assessment of point mutations and copy number variations in Brazilian patients. BMC Med Genet, 15, 1-11. doi: 10.1186/1471-2350-15-55

*Solano, A. R., Aceto, G. M., Delettieres, D., Veschi, S., Neuman, M. I., Alonso, E., & Podesta, E. J. (2012). BRCA1 And BRCA2 analysis of Argentinean breast/ovarian cancer patients selected for age and family history highlights a role for novel mutations of putative south-American origin. Springerplus, 1, 1-10. doi: 10.1186/2193-1801-1-20

Stavropoulou, A. V., Fostira, F., Pertesi, M., Tsitlaidou, M., Voutsinas, G. E., Triantafyllidou, O., & Konstantopoulou, I. (2013). Prevalence of BRCA1 mutations in familial and sporadic greek ovarian cancer cases. PLoS One, 8(3), 1-10. doi: 10.1371/journal.pone.0058182

Toh, G. T., Kang, P., Lee, S. S., Lee, D. S., Lee, S. Y., Selamat, S., & Teo, S. H. (2008). BRCA1 and BRCA2 germline mutations in Malaysian women with early-onset breast cancer without a family history. PLoS One, 3(4), e2024. doi: 10.1371/journal.pone.0002024

Tonin, P., Weber, B., Offit, K., Couch, F., Rebbeck, T. R., & Neuhausen, S. (1996). Frequency of recurrent BRCA1 and BRCA2 mutations in Ashkenazi Jewish breast cancer families. Nat Med, 2(11), 1179-1183.

*Torres-Mejia, G., Royer, R., Llacuachaqui, M., Akbari, M. R., Giuliano, A. R., Martinez-Matsushita, L., & Narod, S. A. (2015). Recurrent BRCA1 and BRCA2 mutations in Mexican women with breast cancer. Cancer Epidemiol Biomarkers Prev, 24(3), 498-505. doi: 10.1158/1055-9965.epi-13-0980

*Torres, D., Rashid, M. U., Gil, F., Umana, A., Ramelli, G; Robledo, J. F., & Hamann, U. (2007). High proportion of BRCA1/2 founder mutations in Hispanic breast/ovarian cancer families from Colombia. Breast Cancer Res Treat, 103(2), 225-232. doi: 10.1007/s10549-006-9370-1

*Torres, D. U. A., Robledo J. F., Caicedo J. J., Quintero E., T. R., & Orozco, A. B. I. (2009). Estudio de factores genéticos para cáncer de mama en Colombia. Univ Med Bogotá, 50(3), 297-301.

*Tung, N., Battelli, C., Allen, B., Kaldate, R., Bhatnagar, S., Bowles, K., & Hartman, A. R. (2015). Frequency of mutations in individuals with breast cancer referred for BRCA1 and BRCA2 testing using next-generation sequencing with a 25-gene panel. Cancer, 121(1), 25-33. doi: 10.1002/cncr.29010

*Vaca-Paniagua, F., Alvarez-Gomez, R. M., Fragoso-Ontiveros, V., Vidal-Millan, S., Herrera, L. A., Cantu, D., & Perez-Plasencia, C. (2012). Full-exon pyrosequencing screening of BRCA germline mutations in Mexican women with inherited breast and ovarian cancer. PLoS One, 7(5), 1-11. doi: 10.1371/journal.pone.0037432

*Villarreal-Garza, C., Weitzel, J. N., Llacuachaqui, M., Sifuentes, E., Magallanes-Hoyos, M. C., Gallardo, L., & Narod, S. A. (2015). The prevalence of BRCA1 and BRCA2 mutations among young Mexican women with triple-negative breast cancer. Breast Cancer Res Treat, 150(2), 389-394. doi: 10.1007/s10549-015-3312-8

Vogel, K. J., Atchley, D. P., Erlichman, J., Broglio, K. R., Ready, K. J., Valero, V., & Arun, B. (2007). BRCA1 and BRCA2 genetic testing in Hispanic patients: mutation prevalence and evaluation of the BRCAPRO risk assessment model. J Clin Oncol, 25(29), 4635-4641. doi: 10.1200/jco.2006.10.4703

*Walsh, T., Casadei, S., Coats, K. H., Swisher, E., Stray, S. M., Higgins, J., & Ciernikova, S. (2006). Spectrum of mutations in BRCA1, BRCA2, CHEK2, and TP53 in families at high risk of breast cancer. Jama, 295(12), 1379-1388.

*Weitzel, J. N., Clague, J., Martir-Negron, A., Ogaz, R., Herzog, J., Ricker, C., & Larson, G. P. (2013). Prevalence and type of BRCA mutations in Hispanics undergoing genetic cancer risk assessment in the southwestern United States: a report from the Clinical Cancer Genetics Community Research Network. J Clin Oncol, 31(2), 210-216. doi: 10.1200/jco.2011.41.0027

*Weitzel, J. N., Lagos, V., Blazer, K. R., Nelson, R., Ricker, C., Herzog, J., & Neuhausen, S. (2005). Prevalence of BRCA mutations and founder effect in high-risk Hispanic families. Cancer Epidemiol Biomarkers Prev, 14(7), 1666-1671. doi: 10.1158/1055-9965.epi-05-0072

Whittemore, A. S., Gong, G., John, E. M., McGuire, V., Li, F. P., Ostrow, K. L., & West, D. W. (2004). Prevalence of BRCA1 mutation carriers among U.S. non-Hispanic Whites. Cancer Epidemiol Biomarkers Prev, 13(12), 2078-2083.

Yu, J. H., Lee, J. W., Son, B. H., Kim, S. W., Park, S. K., Lee, M. H., & Ahn, S. H. (2014). Characteristics of BRCA1/2 Mutation-Positive Breast Cancers in Korea: A Comparison Study Based on Multicenter Data and the Korean Breast Cancer Registry. J Breast Cancer, 17(2), 129-135. doi: 10.4048/jbc.2014.17.2.129

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